Life Science / Physiology  / General Physiology

Dysfunction of Cl^- channels promotes epithelial to mesenchymal transition in oral squamous cell carcinoma via activation of Wnt/β-catenin signaling pathway.

Kei Kakinouchi, Yoshie S, Tsuji S, Murono S, Hazama A

Biochemical and biophysical research communications   555   95 - 101   2021.5（ ISSN:0006-291X ）

Enhanced Retrieval of Taste Associative Memory by Chemogenetic Activation of Locus Coeruleus Norepinephrine Neurons.

Fukabori R, Iguchi Y, Kato S, Takahashi K, Eifuku S, Tsuji S, Hazama A, Uchigashima M, Watanabe M, Mizuma H, Cui Y, Onoe H, Hikishima K, Yasoshima Y, Osanai M, Inagaki R, Fukunaga K, Nishijo T, Momiyama T, Benton R, Kobayashi K

The Journal of neuroscience : the official journal of the Society for Neuroscience   40 ( 43 )   8367 - 8385   2020.10（ ISSN:0270-6474 ）

Cesium suppresses fibroblast proliferation and migration.

Khatun Z, Nishimura N, Kobayashi D, Hazama A

Fukushima journal of medical science   66 ( 2 )   97 - 102   2020.8（ ISSN:0016-2590 ）

血管作動薬投与に対する心機能変化と血管機能変化との関係　ウサギにおける実験的検討

堀越 裕子, 勝田 新一郎, 挾間 章博

日本臨床生理学会雑誌   50 ( 3 )   127 - 132   2020.8（ ISSN:0286-7052 ）

セシウムによる線維芽細胞の増殖と転移の抑制(Cesium suppresses fibroblast proliferation and migration)

Khatun Ziasmin, Nishimura Natsumi, Kobayashi Daisuke, Hazama Akihiro

Fukushima Journal of Medical Science   66 ( 2 )   97 - 102   2020.8（ ISSN:0016-2590 ）

Negative chronotropic and inotropic effects of lubiprostone on iPS cell-derived cardiomyocytes via activation of CFTR.

Akita H, Yoshie S, Ishida T, Takeishi Y, Hazama A

BMC complementary medicine and therapies   20 ( 1 )   118   2020.4

塩素イオンチャネルは脂肪細胞の分化においてRab8a発現を介して脂肪滴形成を調節する(Cl- channels regulate lipid droplet formation via Rab8a expression during adipocyte differentiation)

Ouchi Kanae, Yoshie Susumu, Miyake Masao, Hazama Akihiro

Bioscience, Biotechnology, and Biochemistry   84 ( 2 )   247 - 255   2020.2（ ISSN:0916-8451 ）

Cl- channels regulate lipid droplet formation via Rab8a expression during adipocyte differentiation.

Ouchi K, Yoshie S, Miyake M, Hazama A

Bioscience, biotechnology, and biochemistry   84 ( 2 )   247 - 255   2020.2（ ISSN:0916-8451 ）

Association between Changes in Cardiac Function and Changes in Vascular Function in Response to Vasoactive Drugs in Rabbits

HORIKOSHI Yuko, KATSUDA Shin-ichiro, HAZAMA Akihiro

Journal of Clinical Physiology   50 ( 3 )   127 - 132   2020（ ISSN:0286-7052 ）

Airway regeneration using iPS cell-derived airway epithelial cells with Cl^- channel function.

Yoshie S, Omori K, Hazama A

Channels (Austin, Tex.)   13 ( 1 )   227 - 234   2019.12（ ISSN:1933-6950 ）

UVA Photoprotective Activity of Brown Macroalgae <i>Sargassum cristafolium</i>.

Prasedya ES, Syafitri SM, Geraldine BAFD, Hamdin CD, Frediansyah A, Miyake M, Kobayashi D, Hazama A, Sunarpi H

Biomedicines   7 ( 4 )   2019.9

Functional characterization of various channel-expressing central airway epithelial cells from mouse induced pluripotent stem cells.

Yoshie S, Nakamura R, Kobayashi D, Miyake M, Omori K, Hazama A

Journal of cellular physiology   234 ( 9 )   15951 - 15962   2019.2（ ISSN:0021-9541 ）

Effectiveness of Methanol Solvent Extraction for Red Macroalgae Acanthophora spicifera Antitumoric Activity

Prasedya E.S., Martyasari N.W.R., Hamdin C.D., Miyake M., Kobayashi D., Widyastuti S., Hazama A., Sunarpi H.

Pharmacognosy Journal   11 ( 3 )   450 - 454   2019.1

【Glymphatic system-脳のゴミ処理とその異常】Glymphatic systemにおけるアクアポリンの役割　脳の清掃を担うglymphatic系とアクアポリン

挾間 章博

Clinical Neuroscience   37 ( 1 )   42 - 45   2019.1（ ISSN:0289-0585 ）

The Cytotoxic Effects of Geranylgeranylacetone Are Attenuated in the High-Glucose Condition.

Nakano Y, Kobayashi D, Miyake M, Kanno R, Murakawa M, Hazama A

BioResearch open access   8 ( 1 )   162 - 168   2019（ ISSN:2164-7844 ）

Evaluation of Indonesian selected macroalgae for their antitumor and cytoprotective activity

Prasedya E.S., Ariyana M., Hamdin C.D., Nikmatullah A., Yoshie S., Miyake M., Kobayashi D., Hazama A., Sunarpi H.

Journal of Applied Pharmaceutical Science   8 ( 11 )   123 - 130   2018.11

Heparin cross-linked collagen sponge scaffolds improve functional regeneration of rat tracheal epithelium.

Nakamura R, Tani A, Yoshie S, Ikeda M, Wada I, Hazama A, Nomoto Y, Tada Y, Nakamura T, Omori K

Journal of tissue engineering and regenerative medicine   11 ( 11 )   3027 - 3037   2017.11（ ISSN:1932-6254 ）

Nesfatin-1 inhibits voltage gated K⁺ channels in pancreatic beta cells.

Maejima Y, Horita S, Kobayashi D, Aoki M, O'hashi R, Imai R, Sakamoto K, Mori M, Takasu K, Ogawa K, Takenoshita S, Zhao S, Hazama A, Shimomura K

Peptides   95   10 - 15   2017.9（ ISSN:0196-9781 ）

中心動脈圧脈波の二次微分波はどこまで粥状硬化の進行を反映するか　22〜24ヵ月齢の正常およびKHCウサギにおける実験的検討

勝田 新一郎, 挾間 章博, 高沢 謙二

日本臨床生理学会雑誌   47 ( 2 )   95 - 103   2017.5（ ISSN:0286-7052 ）

Cesium reversibly suppresses HeLa cell proliferation by inhibiting cellular metabolism.

Kobayashi D, Kakinouchi K, Nagae T, Nagai T, Shimura K, Hazama A

FEBS letters   591 ( 5 )   718 - 727   2017.3（ ISSN:0014-5793 ）

Optimal bovine collagen concentration to achieve tracheal epithelial coverage of collagen sponges.

Suzuki R, Nakamura R, Nakaegawa Y, Nomoto Y, Fujimoto I, Semura K, Hazama A, Omori K

The Laryngoscope   126 ( 12 )   E396 - E403   2016.12（ ISSN:0023-852X ）

Carrageenan delays cell cycle progression in human cancer cells in vitro demonstrated by FUCCI imaging.

Prasedya ES, Miyake M, Kobayashi D, Hazama A

BMC complementary and alternative medicine   16 ( 1 )   270   2016.8

Potential of laryngeal muscle regeneration using induced pluripotent stem cell-derived skeletal muscle cells.

Dirja BT, Yoshie S, Ikeda M, Imaizumi M, Nakamura R, Otsuki K, Nomoto Y, Wada I, Hazama A, Omori K

Acta oto-laryngologica   136 ( 4 )   391 - 6   2016（ ISSN:0001-6489 ）

Regeneration of tracheal epithelium using mouse induced pluripotent stem cells.

Ikeda M, Imaizumi M, Yoshie S, Otsuki K, Miyake M, Hazama A, Wada I, Omori K

Acta oto-laryngologica   136 ( 4 )   373 - 8   2016（ ISSN:0001-6489 ）

大動脈局所脈波速度と大動脈脈波速度との関係　各月齢の正常および遺伝性高コレステロール血症ウサギにおける実験的検討

勝田 新一郎, 挾間 章博, 高沢 謙二

日本臨床生理学会雑誌   45 ( 5 )   141 - 149   2015.12（ ISSN:0286-7052 ）

中心動脈圧脈波の二次微分波の有用性に関する実験的検討

勝田 新一郎, 堀越 裕子, 三宅 将生, 挾間 章博, 高沢 謙二

日本臨床生理学会雑誌   44 ( 5 )   181 - 187   2014.12（ ISSN:0286-7052 ）

Local pulse wave velocity directly reflects increased arterial stiffness in a restricted aortic region with progression of atherosclerotic lesions.

Katsuda S, Takazawa K, Miyake M, Kobayashi D, Kusanagi M, Hazama A

Hypertension research : official journal of the Japanese Society of Hypertension   37 ( 10 )   892 - 900   2014.10（ ISSN:0916-9636 ）

局所脈波伝搬速度はアテローム性動脈硬化病変の進行を示す限局的大動脈部位における動脈壁硬化増加を直接的に反映する(Local pulse wave velocity directly reflects increased arterial stiffness in a restricted aortic region with progression of atherosclerotic lesions)

Katsuda Shin-ichiro, Takazawa Kenji, Miyake Masao, Kobayashi Daisuke, Kusanagi Masahiko, Hazama Akihiro

Hypertension Research   37 ( 10 )   892 - 900   2014.10（ ISSN:0916-9636 ）

Chronic phencyclidine treatment induces long-lasting glutamatergic activation of VTA dopamine neurons.

Uramura K, Maejima Y, Shimomura K, Santoso P, Katsuda S, Kobayashi D, Jodo E, Kodaira M, Otgon-Uul Z, Yang Y, Sakuma K, Takigawa M, Hazama A, Yada T

Neuroscience letters   564   72 - 7   2014.4（ ISSN:0304-3940 ）

Povidone-iodine-induced cell death in cultured human epithelial HeLa cells and rat oral mucosal tissue

Sato S., Miyake M., Hazama A., Omori K.

Drug and Chemical Toxicology   37 ( 3 )   268 - 275   2014.1（ ISSN:01480545 ）

Subservient relationship of the peripheral second systolic pressure peak to the central hemodynamic parameters is preserved, irrespective of atherosclerosis progression in hypercholesterolemic rabbits.

Katsuda S, Miyashita H, Shimada K, Miyawaki Y, Kojima I, Shiogai Y, Hazama A

Hypertension research : official journal of the Japanese Society of Hypertension   37 ( 1 )   19 - 25   2014.1（ ISSN:0916-9636 ）

高コレステロール血症ウサギにおいて、中心血行動態パラメータに対する末梢二次収縮期圧ピークの従属的関係はアテローム性動脈硬化症の進展にかかわらず保持される(Subservient relationship of the peripheral second systolic pressure peak to the central hemodynamic parameters is preserved, irrespective of atherosclerosis progression in hypercholesterolemic rabbits)

Katsuda Shin-ichiro, Miyashita Hiroshi, Shimada Kazuyuki, Miyawaki Yoshinori, Kojima Iwao, Shiogai Yuri, Hazama Akihiro

Hypertension Research   37 ( 1 )   19 - 25   2014.1（ ISSN:0916-9636 ）

Unprecedented cell-selection using ultra-quick freezing combined with aquaporin expression.

Kato Y, Miyauchi T, Abe Y, Kojić D, Tanaka M, Chikazawa N, Nakatake Y, Ko SB, Kobayashi D, Hazama A, Fujiwara S, Uchida T, Yasui M

PloS one   9 ( 2 )   e87644   2014

Reducing radiation exposure using commonly available objects

KOBAYASHI Daisuke, MIYAKE Masao, KAKAMU Takeyasu, TSUJI Masayoshi, MORI Yayoi, FUKUSHIMA Tetsuhito, HAZAMA Akihiro

Environmental health and preventive medicine   18 ( 4 )   261 - 266   2013.7（ ISSN:1342078X ）

手近な物体を用いた放射線被曝低減(Reducing radiation exposure using commonly available objects)

Kobayashi Daisuke, Miyake Masao, Kakamu Takeyasu, Tsuji Masayoshi, Mori Yayoi, Fukushima Tetsuhito, Hazama Akihiro

Environmental Health and Preventive Medicine   18 ( 4 )   261 - 266   2013.7（ ISSN:1342-078X ）

Reducing radiation exposure using commonly available objects.

Kobayashi D, Miyake M, Kakamu T, Tsuji M, Mori Y, Fukushima T, Hazama A

Environmental health and preventive medicine   18 ( 4 )   261 - 6   2013.7（ ISSN:1342-078X ）

Does the augmentation index of pulse waves truly increase with progression of atherosclerosis? An experimental study with hypercholesterolemic rabbits.

Katsuda S, Miyake M, Kobayashi D, Hazama A, Kusanagi M, Takazawa K

American journal of hypertension   26 ( 3 )   311 - 7   2013.3（ ISSN:0895-7061 ）

伝達関数を用いない末梢動脈圧波から中心動脈圧推定法の粥状硬化進行に対する有効性の検討

勝田 新一郎, 宮下 洋, 塩貝 有里, 小嶋 巌, 宮脇 義徳, 挾間 章博

日本臨床生理学会雑誌   43 ( 1 )   27 - 29   2013.2（ ISSN:0286-7052 ）

Differences in rates of decrease of environmental radiation dose rates by ground surface property in Fukushima City after the Fukushima Daiichi nuclear power plant accident.

Kakamu T, Kanda H, Tsuji M, Kobayashi D, Miyake M, Hayakawa T, Katsuda S, Mori Y, Okouchi T, Hazama A, Fukushima T

Health physics   104 ( 1 )   102 - 7   2013.1（ ISSN:0017-9078 ）

Deep-sea water improves cardiovascular hemodynamics in Kurosawa and Kusanagi-Hypercholesterolemic (KHC) rabbits.

Katsuda S, Yasukawa T, Nakagawa K, Miyake M, Yamasaki M, Katahira K, Mohri M, Shimizu T, Hazama A.

Biol Pharm Bull   31 ( 1 )   38 - 44   2008.1

Potential of heterotopic fibroblasts as autologous transplanted cells for tracheal epithelial regeneration.

Kobayashi K, Suzuki T, Nomoto Y, Tada Y, Miyake M, Hazama A, Nakamura T, Omori K.

Tissue Eng.   13   2175 - 2184   2007

Molecular cloning and characterization of mouse aquaporin 6.

Nagase H, Agren J, Saito A, Liu K, Agre P, Hazama A, Yasui M.

Biochem Biophys Res Commun.   352   12 - 16   2007

Role of Positively Charged Amino Acids in the M2D Transmembrane Helix ofKtr/Trk/HKT Type Cation Transporters

Naoki Kato,Masaro Akai,Lalu Zulkifli, Nobuyuki Matsuda, Yasuhiro Kato,Shinobu Goshima, Akihiro Hazama, Mutsumi Yamagami, Robert Guy, NobuyukiUozumi

Channels   1 ( 3 )   161 - 171   2007

Tissue engineering for regeneration of the tracheal epithelium.

Nomoto Y, Suzuki T, Tada Y, Kobayashi K, Miyake M, Hazama A, Wada I,Kanemaru S, Nakamura T, Omori K.

Ann Otol Rhinol Laryngol.   115   501 - 506   2006

Mild hypertension in young Kurosawa and Kusanagi-hypercholesterolaemic (KHC) rabbits.

Katsuda S, Miyashita H, Takazawa K, Machida N, Kusanagi M, Miyake M,Hazama A.

Physiol Meas.   27   1361 - 1371   2006

Effect of fibroblasts on tracheal epithelial regeneration in vitro.

Kobayashi K, Nomoto Y, Suzuki T, Tada Y, Miyake M, Hazama A, Kanemaru S, Nakamura T, Omori K.

Tissue Eng.   12   2619 - 2628   2006