Updated on 2024/01/25

写真a

 
ZHAO Songji
 
Organization
Fukushima Global Medical Science Center Advanced Clinical Research Center Professor
Title
Professor

Degree

  • PhD ( 2003.3   Hokkaido University )

  • Master ( Baiqiuen Medical College )

  • MD ( Yanbian Medical College )

Research Interests

  • がん分子イメージング, 血管新生, 細胞増殖, がんの分子標的療法, 核医学診断, 放射線, 癌, 心筋血流, 動脈硬化, ポジトロン断層撮影法 (PET), アルファ線内用療法

Research Areas

  • Life Science / Radiological sciences  / Radiation Science

Education

  • Graduate School of Medicine, Hokkaido University   Graduate School of Medicine, Hokkaido University   PhD in Medicine

    - 2003.3

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    Country: Japan

  • Baiqiuen Medical College, Jilin University   MSc

    - 1990.7

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    Country: China

  • 延邊大学    医学部   医学系 医学(6年制日本語班)専攻

    - 1985.7

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    Country: China

Research History

  • 福島県立医科大学 先端臨床研究センター 教授

    2016.4 - Now

  • 北海道大学大学院医学研究科 トレーサー情報分析学分野/分子イメージング講座 特任教授

    2014.4 - 2016.3

  • 北海道大学大学院医学研究科 トレーサー情報分析学分野 教授

    2011.10 - 2014.3

  • 北海道大学大学院医学研究科 トレーサー情報分析学分野 准教授

    2009.4 - 2011.9

  • 北海道大学 大学院医学研究科 トレーサー情報分析学分野 特任講師

    2008.4 - 2009.3

  • 北海道大学 大学院医学研究科 トレーサー情報分析学分野 特任助教

    2007.4 - 2008.3

  • 北海道大学 大学院医学研究科 核医学分野 客員研究員 日本学術振興会 外国人特別研究員

    2005.4 - 2007.3

  • 北海道大学 大学院医学研究科 トレーサ情報解析学講座 助手

    2003.4 - 2005.3

  • 京都大学 大学院医学研究科 核医学科 研究生

    1997.10 - 1999.3

  • 京都大学 大学院医学研究科 核医学科 (財)日中医学協会・中国政府衛生部・中国医学研修生

    1996.10 - 1997.9

  • 中国 延邊大学 医学院附属医院 核医学科 副主任・講師

    1990.7 - 1996.9

  • 中国 延邊大学医学院附属医院 核医学科 医師

    1985.7 - 1987.8

  • Fukushima Medical University   Professor

    2017.2 - Now

  • Fukushima Medical University   Fukushima Global Medical Science Center Advanced Clinical Research Center   Professor

    2016.4 - 2017.2

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Professional Memberships

  • 米国核医学分子イメージング学会(SNMMI)

  • 世界分子イメージング学会(WMIC)

  • 世界核医学生物学大会(WFNMB)

  • アジアオセアニア核医学生物学大会(AOFNMB)

  • 日本核医学会

  • 日本分子イメージング学会

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Qualification acquired

  • 中国医師

      19850709

Papers

  • Dose dependent effect of Sulfamethoxazole on inhibiting K<sub>ATP</sub> channel of mouse pancreatic β cell

    Hiroshi Ogata, Shigeki Kitamura, Makoto Fujiwara, Masaru Shimizu, Chengbo Tan, Songji Zhao, Yuko Maejima, Kenju Shimomura

    Dose Response   21 ( 3 )   1559325823   2023.9

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    Language:English  

  • Endovascular thrombectomy prior to decompressive craniectomy in acute ischemic stroke with low ASPECTS

    Zhao J, Nan G, Zhao S

    Kuwait Medical Journal   55 ( 4 )   343 - 348   2023.9

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    Language:English  

  • Simulation of the Distribution of Astatine-211 Solution Dispersion in a Lab Room

    Kubo H, Takahashi K, Shimoyama S, Zhao S, Ukon N, Ito H

    Nuclear Medicine Communications   42 ( 9 )   1052 - 1059   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1097/MNM.0000000000001430

  • Responses of immune organs following cerebral ischemic stroke

    Tan C, Wang Z, Zheng M, Zhao S, Shichinohe H, Houkin K.

    Journal of Nippon Medical School   88 ( 3 )   227 - 236   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1272/jnms.JNMS.2021_88-308

  • Evaluation of effect of Ninjin'yoeito on regional brain glucose metabolism by 18F-FDG autoradiography with insulin loading in aged mice

    Zhao J, Imai R, Ukon N, Shimoyama S, Tan C, Maejima Y, Omiya Y, Takahashi K, Nan G, Zhao S*, Ito H, Shimomura K

    Frontiers in Nutrition: Section Nutrition and Brain Health   8   657663   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.3389/fnut.2021.657663

  • Evaluation of organ glucose metabolism by 18F-FDG accumulation with insulin loading in aged mice compared with young normal mice.

    Zhao J, Tan C, Imai R, Ukon N, Shimoyama S, Maejima Y, Omiya Y, Takahashi K, Ito H, Nan G, Zhao S*, Shimomura K

    Scientific Reports   12 ( 1 )   7421   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1038/s41598-021-86825-8

  • Structure based analysis of KATP channel with a DEND syndrome mutation in murine skeletal muscle

    Horita S, Ono T, Gonzalez-Resines S, Ono Y, Yamachi M, Zhao S, Domene C, Maejima Y, Shimomura K

    Scientific Reports   11 ( 1 )   6668   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Delta-like 1 homolog (DLK1) as a therapeutic target and its application to radioimmunotherapy in lung cancer (HOT1801 and FIGHT004)

    Takagi H, Zhao S, Muto S, Yamaguchi H, Mine H, Watanabe M, Ozaki Y, Inoue T, Yamaura T, Fukuhara M, Okabe N, Matsumura Y, Hasegawa T, Osugi J, Hoshino M, Higuchi M, Shio Y, Aoki M, Tan C, Shimoyama S, Harada T, Yokouchi H, Nishihara H, Nakamura K, Inano A, Suzuki H

    Lung Cancer   153 ( 3 )   134 - 142   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.lungcan.2021.01.014

  • Effects of feeding conditions on the myocardial and hepatic accumulation of radioiodine-labeled BMIPP in mice

    Yamasaki K, Zhao S, Nishimura M, Shimizu Y, Tamaki N, Takeda H, Kuge Y

    Annals of Nuclear Medicine   35 ( 1 )   59 - 64   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1007/s12149-020-01535-x

  • Preliminary evaluation of astatine-211-labeled bombesin derivatives for targeted alpha therapy

    Aoki M, Zhao S, Takahashi K, Ukon N, Tan C, Shimoyama S, Nishijima K,Ogawa K

    Chemical and Pharmaceutical Bulletin   68 ( 6 )   538 - 545   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Bilateral medial medullary infarction accompanied by cerebral watershed infarction: A case report

    Zhao J, Nan G, Shen G, Zhao S, Ito H

    Radiology Case Reports   14 ( 4 )   1 - 7   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Possibility of cancer-stem-cell-targeted radioimmunotherapy for acute myelogenous leukemia using <sup>211</sup>At-CXCR4 monoclonal antibody.

    Oriuchi N, Aoki M, Ukon N, Washiyama K, Tan C, Shimoyama S, Nishijima KI, Takahashi K, Ito H, Ikezoe T, Zhao S

    Scientific reports   10 ( 1 )   6810   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1038/s41598-020-63557-9

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  • Elimination of tumor hypoxia by eribulin demonstrated by 18F-FMISO hypoxia imaging in human tumor xenograft models

    Zhao S*, Yu W, Ukon N, Tan C, Nishijima K, Shimizu Y, Kei Higashikawa, Shiga T, Yamashita H, Tamaki N, Kuge Y

    EJNMMI Research   9 ( 1 )   51   2019.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1186/s13550-019-0521-x

  • Comparative evaluation of 18F-DiFA and its analogues as novel hypoxia positron emission tomography and 18F-FMISO as the standard

    Nakata N, Kiriu M, Okumura Y, Zhao S, Nishijima K, Shiga T, Tamaki N, Kuge Y, Matsumoto H

    Nucl Med Biol   70   39 - 45   2019.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.nucmedbio.2019.01.008

  • A novel PET probe [18F]DiFA accumulates in hypoxic region via glutathione conjugation following reductive metabolism

    Shimizu Y, Zhao S, Yasui H, Nishijima K, Matsumoto H, Siga T, Tamaki N, Ogawa M, Kuge Y

    Mol Imaging Biol   21 ( 1 )   122 - 129   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1007/s11307-018-1214-y

  • [18F]DPA-714 PET imaging shows immunomodulatory effect of intravenous administration of bone marrow stromal cells after transient focal ischemia.

    Tan C, Zhao S, Higashikawa K, Wang Z, Kawabori M, Abumiya T, Nakayama N, Kazumata K, Ukon N, Yasui H, Tamaki N, Kuge Y, Shichinohe H, Houkin K

    EJNMMI Res   8 ( 1 )   35   2018.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1186/s13550-018-0392-6

  • In vitro uptake and metabolism of [14C]Acetate in rabbit atherosclerotic arteries: Biological basis for atherosclerosis imaging with [11C]Acetate.

    Yamasaki K, Yamashita A, Zhao Y, Shimizu Y, Nishii R, Kawai K, Tamaki N, Zhao S, Asada Y, Kuge Y

    Nucl Med Biol   56 ( 8 )   21 - 25   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.nucmedbio.2017.08.003

  • <sup>111</sup>In-DTPA-d-Phe<sup>-1</sup>-Asp<sup>0</sup>-d-Phe<sup>1</sup>-octreotide exhibits higher tumor accumulation and lower renal radioactivity than <sup>111</sup>In-DTPA-d-Phe<sup>1</sup>-octreotide.

    Oshima N, Akizawa H, Kitaura H, Kawashima H, Zhao S, Zhao Y, Nishijima KI, Kitamura Y, Arano Y, Kuge Y, Ohkura K

    Nuclear medicine and biology   54   18 - 26   2017.11( ISSN:0969-8051

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.nucmedbio.2017.07.002

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  • FMISO accumulation in tumor is dependent on glutathione conjugation capacity in addition to hypoxic state.

    Masaki Y, Shimizu Y, Yoshioka T, Nishijima KI, Zhao S, Higashino K, Numata Y, Tamaki N, Kuge Y

    Annals of nuclear medicine   31 ( 8 )   596 - 604   2017.10( ISSN:0914-7187

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1007/s12149-017-1189-9

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  • Nesfatin-1 inhibits voltage gated K<sup>+</sup> channels in pancreatic beta cells.

    Maejima Y, Horita S, Kobayashi D, Aoki M, O'hashi R, Imai R, Sakamoto K, Mori M, Takasu K, Ogawa K, Takenoshita S, Zhao S, Hazama A, Shimomura K

    Peptides   95   10 - 15   2017.9( ISSN:0196-9781

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.peptides.2017.07.001

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  • Changes in tumor oxygen states after sorafenib therapy evaluated by 18F-fluoromisonidazole hypoxia imaging in a renal cell cancer xenograft

    Yu W, Zhao S, Zhao Y, Fatema CN, Murakami M, Nishijima K, Kitagawa Y, Tamaki N, Kuge Y

    Oncology Letters   in press   2017.6

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  • Altered glucose metabolism and hypoxic response in alloxan-induced diabetic atherosclerosis in rabbits

    Matsuura Y, Yamashita A, Zhao Y, Iwakiri T, Yamasaki K, Sugita C , Koshimoto C, Kitamura K, Kawai K, Tamaki N, Zhao S, Kuge Y, Asada Y

    PLoS One   12 ( 4 )   e0175976   2017.4

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  • Redesign of negatively charged 111In-DTPA-octreotide derivative to reduce renal radioactivity. Nucl Med and Biol

    Oshima N, Akizawa H, Kawashima H, Zhao S, Zhao Y, Nishijima K, Kitamura Y, Arano Y, Kuge Y, Ohkura K

    Nucl Med Biol   48 ( 1 )   16 - 25   2017.1

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  • Optimization of Helical Acquisition Parameters to Preserve Uniformity of Mouse Whole Body using Multipinhole Collimator in Single-Photon Emission Computed Tomography

    Ukon N, Kubo N, Ishikawa M, Zhao S, Tamaki N, Kuge Y

    Results in Physics   2017

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  • Immunoglobulin-G (IgG)-based imaging probe accumulates in M1 macrophage-infiltrated atherosclerotic plaques independent of IgG target molecule expression

    Shimizu Y, Hanzawa H, Zhao Y, Fukura S, Nishijima K, Sakamoto T, Zhao S, Tamaki N, Ogawa M, Kuge Y

    Mol Imaging Biol   2016.12

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  • Dynamic PET evaluation of the elevated FLT uptake level after sorafenib treatment in mice bearing a human renal cell carcinoma xenograft

    Ukon N, Zhao S, Yu W, Shimizu Y, Nishijima K, Kubo N, Kitagawa Y, Tamaki N, Higashikawa K, Yasui H, and Kuge Y

    EJNMMI Research   6 ( 1 )   90   2016.12

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  • INVITED PERSPECTIVE FOR: Advanced Molecular Imaging for Exploring Classical Conditioning and Extinction

    Zhao S, Fatema CN, Zhao JM, and Nan GX

    J Nucl Med   57 ( 9 )   1333   2016.9

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  • The Thymidine Phosphorylase Imaging Agent 123I-IIMU Predicts the Efficacy of Capecitabine.

    Kobashi N, Matsumoto H, Zhao S, Meike S, Okumura Y, Abe T, Akizawa H, Ohkura K, Ken-Ichi N, Tamaki N, Kuge Y

    Journal of nuclear medicine   57 ( 8 )   1276 - 1281   2016.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.2967/jnumed.115.165811

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  • Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice

    Sugimoto M, Shimizu Y, Zhao S, Ukon N, Nishijima K, Wakabayashi M, Yoshioka T, Higashino K, Numata Y, Okuda T, Tamaki N, Hanamatsu H, Igarashi Y, Kuge Y

    Biochimica et biophysica acta   1861 ( 8 Pt A )   688 - 702   2016.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.bbalip.2016.04.019

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  • Imaging Mass Spectrometry Reveals Acyl-Chain- and Region-Specific Sphingolipid Metabolism in the Kidneys of Sphingomyelin Synthase 2-Deficient Mice.

    Sugimoto M, Wakabayashi M, Shimizu Y, Yoshioka T, Higashino K, Numata Y, Okuda T, Zhao S, Sakai S, Igarashi Y, Kuge Y

    PloS one   11 ( 3 )   e0152191   2016.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1371/journal.pone.0152191

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  • The accumulation mechanism of the hypoxia imaging probe "FMISO&quot" by imaging mass spectrometry: possible involvement of low-molecular metabolites.

    Masaki Y, Shimizu Y, Yoshioka T, Tanaka Y, Nishijima KI, Zhao S, Higashino K, Sakamoto S, Numata Y, Yamaguchi Y, Tamaki N, Kuge Y

    Scientific reports   5   16802   2015.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1038/srep16802

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  • Combined Plasma and Tissue Proteomic Study of Atherogenic Model Mouse: Approach To Elucidate Molecular Determinants in Atherosclerosis Development.

    Hanzawa H, Sakamoto T, Kaneko A, Manri N, Zhao Y, Zhao S, Tamaki N, Kuge Y

    Journal of proteome research   14 ( 10 )   4257 - 4269   2015.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1021/acs.jproteome.5b00405

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  • Biodistribution and dosimetry of free 211At and meta-[211At]astatobenzylguanidine (211At-MABG) in normal mice

    10. Ukon N, Zhao S, Washiyama K, Oriuchi N, Tan C, Shimoyama S, Aoki M, Kubo H, Takahashi K, Itoh H

    EJNMMI Physics   7 ( 1 )   58   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1186/s40658-020-00326-7

  • Relationship between biodistribution of a novel thymidine phosphorylase (TP) imaging probe and TP expression levels in normal mice

    Zhao S, Li H, Nishijima K, Zhao Y, Akizawa H, Shimizu Y, Ohkura K, Tamaki N, Kuge Y.

    Annals of nuclear medicine.   29 ( 7 )   582 - 587   2015.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1007/s12149-015-0981-7

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  • Radiolabeled BMIPP for Imaging Hepatic Fatty Acid Metabolism: Evaluation of Hepatic Distribution and Metabolism in Mice at Various Metabolic Statuses Induced by Fasting in Comparison with Palmitic Acid.

    Yamasaki K, Zhao S, Nishimura M, Zhao Y, Yu W, Shimizu Y, Nishijima K, Tamaki N, Takeda H, Kuge Y

    Molecular imaging   14   1 - 11   2015

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  • Irbesartan Attenuates Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits: Noninvasive Imaging of Inflammation by 18F-Fluorodeoxyglucose Positron Emission Tomography.

    Zhao Y, Fukao K, Zhao S, Watanabe A, Hamada T, Yamasaki K, Shimizu Y, Kubo N, Ukon N, Nakano T, Tamaki N, Kuge Y

    Molecular imaging   14   1 - 8   2015

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  • Regulatory Effect of Interleukin-4 in the Innate Inflammatory Response to Rhodococcus aurantiacus Infection in Mice.

    Yimin, Kohanawa M, Zhao S, Li M, Kuge Y, Tamaki N, Watanabe M

    Journal of Interferon & Cytokine Research.   35 ( 3 )   222 - 231   2015.3

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    Language:Japanese   Publishing type:Research paper (other academic)  

    DOI : 10.1089/jir.2014.0107

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  • Differentiation of malignant tumours from granulomas by using dynamic [18F]-fluoro-L-α-methyltyrosine positron emission tomography.

    EJNMMI Research.   5   29   2015.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1186/s13550-015-0109-z

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  • Dual tracer evaluation of dynamic changes in intratumoral hypoxic and proliferative states after radiotherapy of human head and neck cancer xenografts using radiolabeled FMISO and FLT.

    Fatema CN, Zhao S, Zhao Y, Yu W, Nishijima K, Yasuda K, Kitagawa Y, Tamaki N, Kuge Y

    BMC cancer   14   692   2014.9

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1186/1471-2407-14-692

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  • Design, synthesis and biological evaluation of negatively charged ¹¹¹In-DTPA-octreotide derivatives.

    Oshima N, Akizawa H, Zhao S, Zhao Y, Nishijima K, Kitamura Y, Arano Y, Kuge Y, Ohkura K

    Bioorganic & Medicinal Chemistry   22   1377 - 1382   2014.2

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    DOI : 10.1016/j.bmc.2013.12.063

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  • Increased metabolite levels of glycolysis and pentose phosphate pathway in rabbit atherosclerotic arteries and hypoxic macrophage.

    Yamashita A, Zhao Y, Matsuura Y, Yamasaki K, Moriguchi-Goto S, Sugita C, Iwakiri T, Okuyama N, Koshimoto C, Kawai K, Tamaki N, Zhao S, Kuge Y, Asada Y

    PLoS One   9   e86426   2014.1

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    DOI : 10.1371/journal.pone.0086426

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  • Suppressive effects of irbesartan on inflammation and apoptosis in atherosclerotic plaques of apoE-/- mice: molecular imaging with 14C-FDG and 99mTc-annexin A5.

    Zhao Y, Watanabe A, Zhao S, Kobayashi T, Fukao K, Tanaka Y, Nakano T, Yoshida T, Takemoto H, Tamaki N, Kuge Y

    PLoS One   9   e89338   2014.2

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1371/journal.pone.0089338

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  • Assessment of early changes in 3H-fluorothymidine uptake after treatment with gefitinib in human tumor xenograft in comparison with Ki-67 and phospho-EGFR expression.

    Zhao S, Kuge Y, Zhao Y, Takeuchi S, Hirata K, Takei T, Shiga T, Dosaka-Akita H, Tamaki N

    BMC cancer   13   525   2013.11

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    DOI : 10.1186/1471-2407-13-525

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  • Increased intratumoral fluorothymidine uptake levels following multikinase inhibitor sorafenib treatment in a human renal cell carcinoma xenograft model.

    Murakami M, Zhao S, Zhao Y, Yu W, Fatema CN, Nishijima KI, Yamasaki M, Takiguchi M, Tamaki N, Kuge Y

    Oncology Letters   6   667 - 672   2013.9

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.3892/ol.2013.1459

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  • Contribution of Toll-Like Receptor 2 to the Innate Response against Staphylococcus aureus Infection in Mice.

    Yimin, Kohanawa M, Zhao S, Ozaki M, Haga S, Nan G, Kuge Y, Tamaki N

    PLoS One   8 ( 9 )   e74287   2013.9

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1371/journal.pone.0074287

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  • Elevated 18F-FDG Levels in Blood and Organs After Angiotensin II Receptor Blocker Administration: Experiment in Mice Administered Telmisartan.

    Zhao Y, Zhao S, Kuge Y, Tamaki N

    Journal of Nuclear Medicine   54 ( 8 )   1384 - 1388   2013.8

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.2967/jnumed.111.100248

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  • Radiation-induced nitric oxide mitigates tumor hypoxia and radioresistance in a murine SCCVII tumor model.

    Nagane M, Yasui H, Yamamori T, Zhao S, Kuge Y, Tamaki N, Kameya H, Nakamura H, Fujii H, Inanami O

    Biochemical and Biophysical Research Communications   437 ( 3 )   420 - 425   2013.8

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1016/j.bbrc.2013.06.093

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  • Attenuation of apoptosis by telmisartan in atherosclerotic plaques of apolipoprotein E-/- mice: evaluation using technetium 99m-annexin A5.

    Zhao Y, Zhao S, Kuge Y, Strauss HW, Blankenberg FG, Tamaki N

    Molecular Imaging   12 ( 5 )   300 - 309   2013.7

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  • 123I-Iomazenil Single Photon Emission Computed Tomography Visualizes Recovery of Neuronal Integrity by Bone Marrow Stromal Cell Therapy in Rat Infarct Brain.

    Saito H, Magota K, Zhao S, Kubo N, Kuge Y, Shichinohe H, Houkin K, Tamaki N, Kuroda S

    Stroke   44 ( 10 )   2869 - 2874   2013.10

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1161/STROKEAHA.113.001612

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  • Monitoring tumor proliferative response to radiotherapy using (18)F-fluorothymidine in human head and neck cancer xenograft in comparison with Ki-67.

    Fatema CN, Zhao S, Zhao Y, Murakami M, Yu W, Nishijima KI, Tamaki N, Kitagawa Y, Kuge Y

    Annals of Nuclear Medicine   27 ( 4 )   355 - 362   2013.5

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1007/s12149-013-0693-9

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  • Biological characteristics of intratumoral [F-18]‑fluoromisonidazole distribution in a rodent model of glioma.

    Hatano T, Zhao S, Zhao Y, Nishijima K, Kuno N, Hanzawa H, Sakamoto T, Tamaki N, Kuge Y

    International Journal of Oncology   42 ( 3 )   823 - 830   2013.3

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.3892/ijo.2013.1781

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  • Bone marrow stromal cell transplantation enhances recovery of local glucose metabolism after cerebral infarction in rats: a serial 18F-FDG PET study.

    Miyamoto M, Kuroda S, Zhao S, Magota K, Shichinohe H, Houkin K, Kuge Y, Tamaki N

    Journal of Nuclear Medicine   54 ( 1 )   145 - 150   2013.1

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    DOI : 10.2967/jnumed.112.109017

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  • Arterial (18)F-fluorodeoxyglucose uptake reflects balloon catheter-induced thrombus formation and tissue factor expression via nuclear factor-κB in rabbit atherosclerotic lesions.

    Yamashita A, Zhao Y, Zhao S, Matsuura Y, Sugita C, Iwakiri T, Okuyama N, Ohe K, Koshimoto C, Kawai K, Tamaki N, Kuge Y, Asada Y

    Circulation Journal   77 ( 10 )   2626 - 2635   2013

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  • Evaluation of changes in the tumor microenvironment after sorafenib therapy by sequential histology and 18F-fluoromisonidazole hypoxia imaging in renal cell carcinoma.

    Murakami M, Zhao S, Zhao Y, Chowdhury NF, Yu W, Nishijima K, Takiguchi M, Tamaki N, Kuge Y

    International Journal of Oncology   41 ( 5 )   1593 - 1600   2012.11

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    DOI : 10.3892/ijo.2012.1624

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  • Quantitative determination of apoptosis of pancreatic β-cells in a murine model of type 1 diabetes mellitus.

    Watanabe A, Nishijima K, Zhao S, Zhao Y, Tanaka Y, Takemoto H, Strauss HW, Blankenberg FG, Tamaki N, Kuge Y

    Journal of Nuclear Medicine   53 ( 10 )   1585 - 1591   2012.10

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    DOI : 10.2967/jnumed.111.102459

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  • A novel murine model for non-alcoholic steatohepatitis developed by combination of a high-fat diet and oxidized low-density lipoprotein.

    Yimin, Furumaki H, Matsuoka S, Sakurai T, Kohanawa M, Zhao S, Kuge Y, Tamaki N, Chiba H

    Laboratory Investigation   92 ( 2 )   265 - 281   2012.2

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    DOI : 10.1038/labinvest.2011.159

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  • Effect of glycosylation on biodistribution of radiolabeled glucagon-like peptide 1.

    Watanabe A, Nishijima K, Zhao S, Tanaka Y, Itoh T, Takemoto H, Tamaki N, Kuge Y

    Annals of Nuclear Medicine   26 ( 2 )   184 - 191   2012.2

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  • Ferrous ferric chloride downregulates the inflammatory response to Rhodococcus aurantiacus infection in mice.

    Yimin, Tao H, Kohanawa M, Zhao S, Kuge Y, Tamaki N

    Biological & Pharmaceutical Bulletin   35 ( 12 )   2214 - 2223   2012

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  • Radiolabeled uracil derivative as a novel SPECT probe for thymidine phosphorylase: suppressed accumulation into tumor cells by target gene knockdown.

    Li H, Zhao S, Jin Y, Nishijima K, Akizawa H, Ohkura K, Tamaki N, Kuge Y

    Nuclear Medicine Communications   32 ( 12 )   1211 - 1215   2011.12

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    DOI : 10.1097/MNM.0b013e32834b7ea7

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  • Dynamic 11C-methionine PET analysis has an additional value for differentiating malignant tumors from granulomas: an experimental study using small animal PET.

    Zhao S, Kuge Y, Yi M, Zhao Y, Hatano T, Magota K, Nishijima K, Kohanawa M, Tamaki N

    European Journal of Nuclear Medicine and Molecular Imaging   38 ( 10 )   1876 - 1886   2011.10

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    DOI : 10.1007/s00259-011-1865-2

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  • 18F-fluorothymidine PET/CT as an early predictor of tumor response to treatment with cetuximab in human lung cancer xenografts.

    Takeuchi S, Zhao S, Kuge Y, Zhao Y, Nishijima K, Hatano T, Shimizu Y, Kinoshita I, Tamaki N, Dosaka-Akita H

    Oncology Reports   26 ( 3 )   725 - 730   2011.9

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    DOI : 10.3892/or.2011.1338

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  • Localization of deoxyglucose and annexin A5 in experimental atheroma correlates with macrophage infiltration but not lipid deposition in the lesion.

    Zhao Y, Zhao S, Kuge Y, Strauss WH, Blankenberg FG, Tamaki N

    Molecular Imaging and Biology   13 ( 4 )   712 - 720   2011.8

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    DOI : 10.1007/s11307-010-0389-7

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  • Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging.

    Magota K, Kubo N, Kuge Y, Nishijima K, Zhao S, Tamaki N

    European Journal of Nuclear Medicine and Molecular Imaging   38 ( 4 )   742 - 752   2011.4

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    DOI : 10.1007/s00259-010-1683-y

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  • In vitro and in vivo evaluations of a radioiodinated thymidine phosphorylase inhibitor as a tumor diagnostic agent for angiogenic enzyme imaging.

    Akizawa H, Zhao S, Takahashi M, Nishijima K, Kuge Y, Tamaki N, Seki K, Ohkura K

    Nuclear Medicine and Biology   37 ( 4 )   427 - 432   2010.5

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    DOI : 10.1016/j.nucmedbio.2010.01.005

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  • Radioimmunodetection of membrane type-1 matrix metalloproteinase relevant to tumor malignancy with a pre-targeting method.

    Sano K, Temma T, Kuge Y, Kudo T, Kamihashi J, Zhao S, Saji H

    Biological & Pharmaceutical Bulletin   33 ( 9 )   1589 - 1595   2010

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    DOI : 10.1248/bpb.33.1589

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  • Molecular imaging of apoptosis with radio-labeled Annexin A5 focused on the evaluation of tumor response to chemotherapy.

    Kuge Y, Zhao S, Takei T, Tamaki N

    Anticancer Agents in Medicinal Chemistry   9 ( 9 )   1003 - 1011   2009.11

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  • Basic performance test of a prototype PET scanner using CdTe semiconductor detectors.

    Ueno Y, Morimoto Y, Tsuchiya K, Yanagita N, Kojima S, Ishitsu T, Kitaguchi H, Kubo N, Zhao S, Tamaki N, Amemiya K.

    IEEE Trans Nucl Sci   56 ( 1,Pt.1 )   24 - 28   2009

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    DOI : 10.1109/TNS.2008.2004804

  • Mutual modulation between interleukin-10 and interleukin-6 induced by Rhodococcus aurantiacus infection in mice.

    Yimin, Kohanawa M, Ozaki M, Haga S, Fujikawa K, Zhao S, Kuge Y, Tamaki N

    Microbes and Infection   10 ( 14-15 )   1450 - 1458   2008.11

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    DOI : 10.1016/j.micinf.2008.08.013

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  • Prolonged high-fat feeding enhances aortic 18F-FDG and 99mTc-annexin A5 uptake in apolipoprotein E-deficient and wild-type C57BL/6J mice.

    Zhao Y, Kuge Y, Zhao S, Strauss HW, Blankenberg FG, Tamaki N

    Journal of Nuclear Medicine   49 ( 10 )   1707 - 1714   2008.10

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    DOI : 10.2967/jnumed.108.051847

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  • Usefulness of 11C-methionine for differentiating tumors from granulomas in experimental rat models: a comparison with 18F-FDG and 18F-FLT.

    Zhao S, Kuge Y, Kohanawa M, Takahashi T, Zhao Y, Yi M, Kanegae K, Seki K, Tamaki N

    Journal of Nuclear Medicine   49 ( 1 )   135 - 141   2008.1

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    DOI : 10.2967/jnumed.107.044578

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  • Synthesis of a radioiodinated thymidine phosphorylase inhibitor and its preliminary evaluation as a potential SPECT tracer for angiogenic enzyme expression.

    Takahashi M, Seki K, Nishijima K, Zhao S, Kuge Y, Tamaki N, Ohkura K.

    J Label Compd Radiopharm   51 ( 11 )   384 - 387   2008.11

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  • Extensive FDG uptake and its modification with corticosteroid in a granuloma rat model: an experimental study for differentiating granuloma from tumors.

    Zhao S, Kuge Y, Kohanawa M, Takahashi T, Kawashima H, Temma T, Takei T, Zhao Y, Seki K, Tamaki N

    European Journal of Nuclear Medicine and Molecular Imaging   34 ( 12 )   2096 - 2105   2007.12

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    DOI : 10.1007/s00259-007-0529-8

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  • Comparison of 99mTc-annexin A5 with 18F-FDG for the detection of atherosclerosis in ApoE-/- mice.

    Zhao Y, Kuge Y, Zhao S, Morita K, Inubushi M, Strauss HW, Blankenberg FG, Tamaki N

    European Journal of Nuclear Medicine and Molecular Imaging   34 ( 11 )   1747 - 1755   2007.11

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    DOI : 10.1007/s00259-007-0433-2

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  • All-trans retinoic acid enhances murine dendritic cell migration to draining lymph nodes via the balance of matrix metalloproteinases and their inhibitors.

    Darmanin S, Chen J, Zhao S, Cui H, Shirkoohi R, Kubo N, Kuge Y, Tamaki N, Nakagawa K, Hamada J, Moriuchi T, Kobayashi M

    Journal of Immunology   179 ( 7 )   4616 - 4625   2007.10

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  • Comparison of MET-PET and FDG-PET for differentiation between benign lesions and lung cancer in pneumoconiosis.

    Kanegae K, Nakano I, Kimura K, Kaji H, Kuge Y, Shiga T, Zhao S, Okamoto S, Tamaki N

    Annals of Nuclear Medicine   21 ( 6 )   331 - 337   2007.8

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    DOI : 10.1007/s12149-007-0035-x

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  • Evaluating performance of a pixel array semiconductor SPECT system for small animal imaging.

    Kubo N, Zhao S, Fujiki Y, Kinda A, Motomura N, Katoh C, Shiga T, Kawashima H, Kuge Y, Tamaki N

    Annals of Nuclear Medicine   19 ( 7 )   633 - 639   2005.10

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  • Enhanced apoptotic reaction correlates with suppressed tumor glucose utilization after cytotoxic chemotherapy: use of 99mTc-Annexin V, 18F-FDG, and histologic evaluation.

    Takei T, Kuge Y, Zhao S, Sato M, Strauss HW, Blankenberg FG, Tait JF, Tamaki N

    Journal of Nuclear Medicine   46 ( 5 )   794 - 799   2005

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  • Biologic correlates of intratumoral heterogeneity in 18F-FDG distribution with regional expression of glucose transporters and hexokinase-II in experimental tumor.

    Zhao S, Kuge Y, Mochizuki T, Takahashi T, Nakada K, Sato M, Takei T, Tamaki N

    Journal of Nuclear Medicine   46 ( 4 )   675 - 682   2005.4

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  • Does lemon candy decrease salivary gland damage after radioiodine therapy for thyroid cancer?

    Nakada K, Ishibashi T, Takei T, Hirata K, Shinohara K, Katoh S, Zhao S, Tamaki N, Noguchi Y, Noguchi S.

    J Nucl Med   46 ( 2 )   261 - 266   2005.2

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  • Time course of apoptotic tumor response after a single dose of chemotherapy: comparison with 99mTc-annexin V uptake and histologic findings in an experimental model.

    Takei T, Kuge Y, Zhao S, Sato M, Strauss HW, Blankenberg FG, Tait JF, Tamaki N

    Journal of Nuclear Medicine   45 ( 12 )   2083 - 2087   2004.12

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  • Gastrointestinal uptake of FDG after N-butylscopolamine or omeprazole treatment in the rat.

    Yamamoto F, Nakada K, Zhao S, Satoh M, Asaka M, Tamaki N

    Annals of Nuclear Medicine   18 ( 7 )   637 - 640   2004.10

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  • 18F-FDG PET is superior to 67Ga SPECT in the staging of non-Hodgkin's lymphoma.

    Yamamoto F, Tsukamoto E, Nakada K, Takei T, Zhao S, Asaka M, Tamaki N

    Annals of nuclear medicine   18   519 - 526   2004

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  • Feasibility of 99mTc-annexin V for repetitive detection of apoptotic tumor response to chemotherapy: an experimental study using a rat tumor model.

    Kuge Y, Sato M, Zhao S, Takei T, Nakada K, Seki KI, Strauss HW, Blankenberg FG, Tait JF, Tamaki N

    Journal of Nuclear Medicine   45 ( 2 )   309 - 312   2004.2

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  • Effect of steroids on [18F]fluorodeoxyglucose uptake in an experimental tumor model

    Zhao S, Kuge Y, Nakada K, Mochizuki T, Takei T, Okada F, Tamaki N.

    Nucl Med Commun   25 ( 7 )   727 - 730   2004.7

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  • Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism.

    Chen J, Zhao S, Nakada K, Kuge Y, Tamaki N, Okada F, Wang J, Shindo M, Higashino F, Takeda K, Asaka M, Katoh H, Sugiyama T, Hosokawa M, Kobayashi M

    The American Journal of Pathology   162 ( 4 )   1283 - 1291   2003.4

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  • Detection of apoptotic tumor response in vivo after a single dose of chemotherapy with 99mTc-annexin V.

    Mochizuki T, Kuge Y, Zhao S, Tsukamoto E, Hosokawa M, Strauss HW, Blankenberg FG, Tait JF, Tamaki N

    Journal of Nuclear Medicine   44 ( 1 )   92 - 97   2003.1

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  • Fluorodeoxyglucose uptake and glucose transporter expression in experimental inflammatory lesions and malignant tumours: effects of insulin and glucose loading. Nucl Med Commun

    Zhao S, Kuge Y, Tsukamoto E, Mochizuki T, Kato T, Hikosaka K, Nakada K, Hosokawa M, Kohanawa M, Tamaki N.

    Nucl Med Commun   23 ( 6 )   545 - 550   2002.6

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  • FDG uptake and glucose transporter subtype expression in experimental tumor and inflammation models.

    Mochizuki T, Tsukamoto E, Kuge Y, Kanegae K, Zhao S, Hikosaka K, Hosokawa M, Kohanawa M, Tamaki N.

    J Nucl Med   42 ( 10 )   1551 - 1555   2001.10

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  • Effects of insulin and glucose loading on FDG uptake in experimental malignant tumours and inflammatory lesions.

    Zhao S, Kuge Y, Tsukamoto E, Mochizuki T, Kato T, Hikosaka K, Hosokawa M, Kohanawa M, Tamaki N.

    Eur J Nucl Med   28 ( 6 )   730 - 735   2001.6

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  • Avidin chase can raduce myelotoxicity associated with radioimmunotherapy of experimental liver micrometastases in mice.

    Sato N, Saga T, Sakahara H, Nakamoto Y, Zhao S, Kuroki M, Endo K, Konishi J.

    Jpn J Cancer Res   91 ( 6 )   622 - 628   2000.6

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  • Radioimmunotherapy of human glioma xenografts in nude mice by indium-111 labelled internalising monoclonal antibody.

    Saga T, Sakahar H, Nakamoto Y, Sato N, Zhao S, Aoki T, Miyatake S, Namba Y, Konishi J.

    Eur J Cancer   35 ( 8 )   1281 - 1285   1999.8

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  • Radioimmunotherapy for liver micometastases in mice: pharmacokinetics, dose estimation, and long-term effect.

    Saga T, Sakahara H, Nakamoto Y, Sato N, Zhao S, Iido Y, Kuroki M, Endo K, Konishi J.

    Jpn J Cancer Res   90 ( 3 )   342 - 348   1999.3

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  • A novel immunoscintigraphy technique using metabolizable linker with angiotensin II treatment.

    Nakamoto Y, Sakahar H, Saga T, Sato N, Zhao S, Arano Y, Fujioka Y, Saji H, Konishi J.

    Br J Cancer   79 ( 11/12 )   1794 - 1799   1999.4

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    DOI : 10.1038/sj.bjc.6690286

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  • The relationship of glycosylation and isoelectric point with tumor accumulation of avidin.

    Yao Z, Zhang M, Sakahara H, Nakamoto Y, Higasi T, Zhao S, Sato N, Arano Y, Konishi J.

    J Nucl Med   40 ( 3 )   479 - 483   1999.3

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  • A radioiodinated biocytin derivative for in-vivo applications.

    Nakamoto Y, Sakahara H, Saga T, Yao Z, Zhang M, Sato N, Zhao S, Arano Y, Ono M, Saji H, Konishi J.

    Nucl Med Commun   19 ( 10 )   963 - 969   1998.10

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  • Imaging of intraperitoneal tumors with technetium-99m GSA.

    Yao Z, Zhang M, Sakahara H, Saga T, Nakamoto Y, Sato N, Zhao S, Arano Y, Konishi J.

    Ann Nucl Med   12 ( 2 )   115 - 118   1998.4

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  • Effect of administration route and dose of streptavidin or biotin on the tumor uptake of radioactivity in intraperitoneal tumor with multistep targeting.

    Zhang M, Yao Z, Sakahara H, Saga T, Nakamoto Y, Sato N, Zhao S, Nakada H, Yamashina I, Konishi J.

    Nucl Med Biol   25 ( 2 )   101 - 105   1998.2

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    DOI : 10.1016/S0969-8051(97)00157-1

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  • Three-step tumor imaging with biotinylated monoclonal antibody, streptavidin and &lt;SUP&gt;111&lt;/SUP&gt;In-DTPA-biotin.

    Nakamoto Y, Saga T, Sakahara H, Yao Z, Zhang M, Sato N, Zhao S, Nakada H, Yamashina I, Konishi J:

    Nucl Med Biol   25 ( 2 )   95 - 99   1998.2

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    DOI : 10.1016/S0969-8051(97)00155-8

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  • Detection of altered adhesion molecule expression in experimental tumors by a radiolabeled monoclonal antibody.

    Saga T, Sakahara H, Yao Z, Nakamoto Y, Sato N, Hattori N, Zhang M, Zhao S, Aoki T, Miyatate S, Namba Y, Konishi J

    Jpn J Cancer Res   88 ( 12 )   1171 - 1180   1997.10

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  • 脳梗塞をターゲットとした骨髄間質細胞移植―新たな培養・移植・イメージング技術による展開

    黒田敏, 宮本倫行, 山内朋裕, 斉藤久泰, 伊東雅基, 川堀真人, 杉山拓, 千葉泰弘, 七戸秀夫, 宝金清博, 久下裕司, 趙松吉, 玉木長良

    再生医療   11   136   2012

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  • 骨髄間質細胞移植は脳梗塞後の局所糖代謝を改善する―小動物用PET/CTによる検討

    宮本倫行, 黒田敏, 趙松吉, 孫田恵一, 伊東雅基, 川堀真人, 丸一勝彦, 七戸秀夫, 宝金清博, 久下裕司, 玉木長良

    再生医療   11   191   2012

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  • 新医薬品開発(又は創薬・育薬)における分子イメージング技術の現状と進歩

    久下裕司, 西嶋剣一, 孫田恵一, 趙松吉, 玉木長良

    医薬品医療機器レギュラトリーサイエンス   43 ( 4 )   308 - 313   2012

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  • 動脈血管壁への&lt;sup&gt;18&lt;/sup&gt;F‐フルオロデオキシグルコース集積は血栓形成能を反映する

    山下篤, 趙芫, 趙松吉, 松浦祐之介, 松浦祐之介, 越本知大, 川井恵一, 久下祐司, 浅田祐士郎

    日本血栓止血学会誌   23 ( 2 )   210   2012

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  • アスパラギン酸で負電荷を付与した&lt;sup&gt;111&lt;/sup&gt;In‐DTPA‐D‐Phe&lt;sup&gt;1&lt;/sup&gt;‐オクトレオチド誘導体の受容体親和性および体内動態の評価

    大島伸宏, 秋澤宏行, 趙松吉, 趙芫, 西嶋剣一, 北村陽二, 荒野泰, 久下裕司, 久下裕司, 大倉一枝

    日本薬学会年会要旨集   132nd ( 4 )   146   2012

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  • アスパラギン酸で負電荷を付与した&lt;sup&gt;111&lt;/sup&gt;In‐DTPA‐D‐Phe&lt;sup&gt;1&lt;/sup&gt;‐オクトレオチド誘導体の受容体親和性および体内動態の評価

    大島伸宏, 秋澤宏行, 趙松吉, 趙芫, 西嶋剣一, 北村陽二, 荒野泰, 久下裕司, 久下裕司, 大倉一枝

    日本薬学会年会要旨集   132nd ( 4 )   146   2012

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  • 放射性標識核酸誘導体による腫瘍の核医学診断と内用療法

    秋澤宏行, 趙松吉, 高橋正幸, 西嶋剣一, 松本博樹, 関興一, 玉木長良, 久下裕司, 大倉一枝

    日本薬学会年会要旨集   132nd ( 1 )   116   2012

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  • 放射性標識核酸誘導体による腫瘍の核医学診断と内用療法

    秋澤宏行, 趙松吉, 高橋正幸, 西嶋剣一, 松本博樹, 関興一, 玉木長良, 久下裕司, 大倉一枝

    日本薬学会年会要旨集   132nd ( 1 )   116   2012

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  • 新規腫瘍内低酸素イメージング剤18F‐HIC101の有用性の評価

    中田徳仁, 奥村侑紀, 永田絵里子, 桐生真登, 林明希男, 西嶋剣一, 趙松吉, 玉木長良, 久下裕司, 久下裕司, 松本博樹

    日本薬学会年会要旨集   132nd ( 4 )   104   2012

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  • 新規腫瘍内低酸素イメージング剤18F‐HIC101の有用性の評価

    中田徳仁, 奥村侑紀, 永田絵里子, 桐生真登, 林明希男, 西嶋剣一, 趙松吉, 玉木長良, 久下裕司, 久下裕司, 松本博樹

    日本薬学会年会要旨集   132nd ( 4 )   104   2012

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  • チミジンホスホリラーゼイメージング剤[&lt;sup&gt;123&lt;/sup&gt;I]5‐iodo‐6‐[(2‐iminoimidazokidinyl)methyl]uracilの開発:タンパク結合測定と画像化の検討

    西嶋剣一, 越田早織, 趙松吉, 秋澤宏行, 大倉一枝, 松本博樹, 志賀哲, 玉木長良, 久下裕司, 久下裕司

    日本薬学会年会要旨集   132nd ( 4 )   106   2012

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  • チミジンホスホリラーゼイメージング剤[&lt;sup&gt;123&lt;/sup&gt;I]5‐iodo‐6‐[(2‐iminoimidazokidinyl)methyl]uracilの開発:タンパク結合測定と画像化の検討

    西嶋剣一, 越田早織, 趙松吉, 秋澤宏行, 大倉一枝, 松本博樹, 志賀哲, 玉木長良, 久下裕司, 久下裕司

    日本薬学会年会要旨集   132nd ( 4 )   106   2012

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  • 骨髄間質細胞移植は脳梗塞周囲の神経受容体機能を改善させる―&lt;sup&gt;123&lt;/sup&gt;I‐iomazenil SPECTによる検討

    齋藤久泰, 黒田敏, 宮本倫行, 山内朋裕, 七戸秀夫, 趙松吉, 孫田惠一, 久保直樹, 久下裕司, 玉木長良, 寶金清博

    脳循環代謝   24 ( 1 )   216   2012

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  • 骨髄間質細胞移植は脳梗塞周囲の神経受容体機能を改善させる―&lt;sup&gt;123&lt;/sup&gt;I‐iomazenil SPECTによる検討

    齋藤久泰, 黒田敏, 宮本倫行, 山内朋裕, 七戸秀夫, 趙松吉, 孫田惠一, 久保直樹, 久下裕司, 玉木長良, 寶金清博

    脳循環代謝   24 ( 1 )   216   2012

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  • 新医薬品開発(又は創薬・育薬)における分子イメージング技術の現状と進歩。

    久下 裕司、西嶋 剣一、孫田 恵一、趙 松吉、玉木 長良

    医薬品医療機器レギュラトリーサイエンスPMDRS   43 ( 4 )   308 - 313   2012

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  • 小動物用PETを用いた[11C]Flumazenilのコンパートメントモデル解析におけるMaximum a posteriori(MAP)再構成の評価

    孫田惠一, 久保直樹, 趙松吉, 久下裕司, 玉木長良, 加藤千恵次

    北海道放射線技術雑誌   71   127   2011

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  • 特集1. 心臓核医学の最先端 1. 動脈硬化イメージング-実験的検討。

    久下 裕司、趙 芫、趙 松吉、玉木 長良

    PET Journal   18 ( Summer )   14 - 16   2012

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  • 核医学検査の新しい展開~治療戦略への応用 治療戦略に役立つ放射性薬剤の開発

    久下裕司, 久下裕司, 西嶋剣一, 趙松吉

    映像情報Medical   43 ( 11 )   842-849,830   2011

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  • 小動物用PETを用いた&lt;sup&gt;11&lt;/sup&gt;C‐FlumazenilのBinding potential解析におけるMaximum a posteriori再構成の評価

    孫田惠一, 久保直樹, 趙松吉, 久下裕司, 平田健司, 服部直也, 志賀哲, 加藤千恵次, 玉木長良

    核医学   48 ( 3 )   329   2011

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  • 小動物用PETを用いた[11C]Flumazenilのコンパートメントモデル解析におけるMaximum a posteriori(MAP)再構成の評価

    孫田惠一, 久保直樹, 趙松吉, 久下裕司, 玉木長良, 加藤千恵次

    北海道放射線技術雑誌   71   127   2011

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  • ヒト癌移植マウスにおける抗EGFR抗体(Cetuximab)による分子標的療法:&lt;sup&gt;18&lt;/sup&gt;F‐FMISOを用いた早期治療効果評価

    趙松吉, 久下裕司, 趙芫, 竹内啓, 村上正紘, 李花, 西嶋剣一, 竹井俊樹, 秋田弘俊, 玉木長良

    核医学   48 ( 3 )   335   2011

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  • 核医学検査の新しい展開~治療戦略への応用 治療戦略に役立つ放射性薬剤の開発

    久下裕司, 久下裕司, 西嶋剣一, 趙松吉

    映像情報Medical   43 ( 11 )   842-849,830   2011

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  • 心筋交感神経終末機能評価薬剤&lt;sup&gt;11&lt;/sup&gt;C‐hydroxyephedrineの安全性評価

    西嶋剣一, 吉永恵一郎, 趙松吉, 趙芫, 真鍋治, 加藤千恵次, 阿保憲史, 玉木長良, 久下裕司, 久下裕司

    核医学   48 ( 3 )   318   2011

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  • 小動物用PETを用いた&lt;sup&gt;11&lt;/sup&gt;C‐FlumazenilのBinding potential解析におけるMaximum a posteriori再構成の評価

    孫田惠一, 久保直樹, 趙松吉, 久下裕司, 平田健司, 服部直也, 志賀哲, 加藤千恵次, 玉木長良

    核医学   48 ( 3 )   329   2011

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  • ApoE‐/‐マウス動脈硬化に対するテルミサルタンの治療効果:&lt;sup&gt;99m&lt;/sup&gt;Tc‐annexin A5による評価

    趙芫, 趙松吉, 久下裕司, 玉木長良

    核医学   48 ( 3 )   292   2011

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  • ヒト癌移植マウスにおける抗EGFR抗体(Cetuximab)による分子標的療法:&lt;sup&gt;18&lt;/sup&gt;F‐FMISOを用いた早期治療効果評価

    趙松吉, 久下裕司, 趙芫, 竹内啓, 村上正紘, 李花, 西嶋剣一, 竹井俊樹, 秋田弘俊, 玉木長良

    核医学   48 ( 3 )   335   2011

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  • ラット脳腫瘍における間欠的低酸素の可視化と放射線感受性に与える影響

    安井博宣, 新坊弦也, 山盛徹, 永根大幹, 趙松吉, 久下祐司, 稲波修

    日本獣医学会学術集会講演要旨集   152nd   316   2011

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  • 心筋交感神経終末機能評価薬剤&lt;sup&gt;11&lt;/sup&gt;C‐hydroxyephedrineの安全性評価

    西嶋剣一, 吉永恵一郎, 趙松吉, 趙芫, 真鍋治, 加藤千恵次, 阿保憲史, 玉木長良, 久下裕司, 久下裕司

    核医学   48 ( 3 )   318   2011

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  • &lt;sup&gt;18&lt;/sup&gt;F‐Fluorothymidine(FLT)による抗EGFR抗体薬の早期治療効果予測

    竹内啓, 趙松吉, 趙松吉, 久下裕司, 趙莞, 西嶋剣一, 波多野利行, 清水康, 木下一郎, 玉木長良, 秋田弘俊

    日本臨床腫瘍学会学術集会プログラム・抄録集   9th   367   2011

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  • ApoE‐/‐マウス動脈硬化に対するテルミサルタンの治療効果:&lt;sup&gt;99m&lt;/sup&gt;Tc‐annexin A5による評価

    趙芫, 趙松吉, 久下裕司, 玉木長良

    核医学   48 ( 3 )   292   2011

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  • 骨髄間質細胞移植は脳梗塞後の局所糖代謝を改善する―小動物用PET/CTによる検討

    宮本倫行, 黒田敏, 七戸秀夫, 伊東雅基, 川堀真人, 趙松吉, 孫田恵一, 久下裕司, 玉木長良, 宝金清博

    脳循環代謝   23 ( 1 )   142   2011

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  • ラット脳腫瘍における間欠的低酸素の可視化と放射線感受性に与える影響

    安井博宣, 新坊弦也, 山盛徹, 永根大幹, 趙松吉, 久下祐司, 稲波修

    日本獣医学会学術集会講演要旨集   152nd   316   2011

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  • &lt;sup&gt;18&lt;/sup&gt;F‐Fluorothymidine(FLT)による抗EGFR抗体薬の早期治療効果予測

    竹内啓, 趙松吉, 趙松吉, 久下裕司, 趙莞, 西嶋剣一, 波多野利行, 清水康, 木下一郎, 玉木長良, 秋田弘俊

    日本臨床腫瘍学会学術集会プログラム・抄録集   9th   367   2011

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  • 不安定プラークの検出における&lt;sup&gt;18&lt;/sup&gt;F‐FDGと&lt;sup&gt;99m&lt;/sup&gt;Tc‐annexin A5の有用性:Apo E&lt;sup&gt;-/-&lt;/sup&gt;マウスの動脈硬化病変への集積と病理学的検討

    趙芫, 趙松吉, 玉木長良, 久下裕司

    核医学   47 ( 4 )   505 - 506   2010

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  • 骨髄間質細胞移植は脳梗塞後の局所糖代謝を改善する―小動物用PET/CTによる検討

    宮本倫行, 黒田敏, 七戸秀夫, 伊東雅基, 川堀真人, 趙松吉, 孫田恵一, 久下裕司, 玉木長良, 宝金清博

    脳循環代謝   23 ( 1 )   142   2011

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  • チミジンホスホリラーゼを標的とする新規腫瘍イメージング剤の開発:siRNA導入による腫瘍細胞への集積低下

    李花, 趙松吉, 西嶋剣一, 秋澤宏行, 関興一, 大倉一枝, 玉木長良, 久下裕司

    核医学   47 ( 3 )   S219   2010

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  • 特集1核医学検査の新しい展開~治療戦略に役立つ放射性薬剤の開発。

    久下 裕司、西嶋 剣一、趙 松吉

    映像情報メディカル   43 ( 11 )   842 - 849   2011

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  • 肉芽腫・腫瘍におけるFMISO‐PETの有用性:小動物用PETを用いた基礎的検討

    趙松吉, 久下裕司, 趙芫, 伊敏, 波多野利行, 鈴木幸太郎, 孫田恵一, 西嶋剣一, 小華和柾志, 玉木長良

    核医学   47 ( 3 )   S219   2010

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  • 高用量ARB投与によるFDGの組織集積の上昇:Telmisartan投与マウスでの検討

    趙芫, 趙松吉, 久下裕司, 玉木長良

    核医学   47 ( 3 )   S282   2010

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  • 不安定プラークの検出における&lt;sup&gt;18&lt;/sup&gt;F‐FDGと&lt;sup&gt;99m&lt;/sup&gt;Tc‐annexin A5の有用性:Apo E&lt;sup&gt;-/-&lt;/sup&gt;マウスの動脈硬化病変への集積と病理学的検討

    趙芫, 趙松吉, 玉木長良, 久下裕司

    核医学   47 ( 4 )   505 - 506   2010

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  • 臨床用半導体PET装置により描出される腫瘍内FDG分布のオートラジオグラフィーによる検証

    竹内渉, 波多野利行, 趙松吉, 趙芫, 森本裕一, 久野範人, 久下裕司, 玉木長良

    核医学   47 ( 3 )   S237   2010

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  • チミジンホスホリラーゼを標的とする新規腫瘍イメージング剤の開発:siRNA導入による腫瘍細胞への集積低下

    李花, 趙松吉, 西嶋剣一, 秋澤宏行, 関興一, 大倉一枝, 玉木長良, 久下裕司

    核医学   47 ( 3 )   S219   2010

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  • ヒト癌細胞移植マウスにおける抗EGFR抗体(cetuximab)による分子標的療法:FLTを用いた早期治療効果評価

    竹内啓, 趙松吉, 久下祐司, 趙莞, 西嶋剣一, 波多野利行, 清水康, 木下一郎, 玉木長良, 秋田弘俊

    日本臨床腫瘍学会学術集会プログラム・抄録集   8th   188   2010

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  • 肉芽腫・腫瘍におけるFMISO‐PETの有用性:小動物用PETを用いた基礎的検討

    趙松吉, 久下裕司, 趙芫, 伊敏, 波多野利行, 鈴木幸太郎, 孫田恵一, 西嶋剣一, 小華和柾志, 玉木長良

    核医学   47 ( 3 )   S219   2010

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  • 高用量ARB投与によるFDGの組織集積の上昇:Telmisartan投与マウスでの検討

    趙芫, 趙松吉, 久下裕司, 玉木長良

    核医学   47 ( 3 )   S282   2010

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  • ヒト癌細胞移植マウスにおける抗EGFR抗体(Cetuximab)による分子標的療法:FLTを用いた早期治療効果評価

    竹内啓, 趙松吉, 久下裕司, 趙芫, 波多野利行, 西嶋剣一, 清水康, 木下一郎, 秋田弘俊, 玉木長良

    核医学   46 ( 3 )   S260   2009

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  • 臨床用半導体PET装置により描出される腫瘍内FDG分布のオートラジオグラフィーによる検証

    竹内渉, 波多野利行, 趙松吉, 趙芫, 森本裕一, 久野範人, 久下裕司, 玉木長良

    核医学   47 ( 3 )   S237   2010

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  • 一体型小動物用PET/SPECT/CT装置の性能評価

    孫田惠一, 孫田惠一, 久保直樹, 鈴木幸太郎, 西嶋剣一, 趙松吉, 久下裕司, 玉木長良

    核医学   46 ( 3 )   S271-S272   2009

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  • ヒト癌細胞移植マウスにおける抗EGFR抗体(cetuximab)による分子標的療法:FLTを用いた早期治療効果評価

    竹内啓, 趙松吉, 久下祐司, 趙莞, 西嶋剣一, 波多野利行, 清水康, 木下一郎, 玉木長良, 秋田弘俊

    日本臨床腫瘍学会学術集会プログラム・抄録集   8th   188   2010

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  • ヒト癌細胞移植マウスにおける抗VEGF抗体(Bevacizumab)による分子標的療法:FLTを用いた早期治療効果評価

    趙松吉, 久下裕司, 趙芫, 竹内啓, 波多野利行, 西嶋剣一, 木下一郎, 秋田弘毅, 玉木長良

    核医学   46 ( 3 )   S260-S261   2009

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  • 肉芽腫・腫瘍の鑑別診断におけるdynamic &lt;sup&gt;11&lt;/sup&gt;C‐MET‐PETの有用性:小動物用PETを用いた基礎的検討

    趙松吉, 久下裕司, 伊敏, 趙芫, 竹内啓, 波多野利行, 鈴木幸太郎, 孫田惠一, 西嶋剣一, 小華和柾志, 玉木長良

    核医学   46 ( 3 )   S271   2009

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  • ヒト癌細胞移植マウスにおける抗EGFR抗体(Cetuximab)による分子標的療法:FLTを用いた早期治療効果評価

    竹内啓, 趙松吉, 久下裕司, 趙芫, 波多野利行, 西嶋剣一, 清水康, 木下一郎, 秋田弘俊, 玉木長良

    核医学   46 ( 3 )   S260   2009

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  • 核医学による動脈硬化イメージング

    久下裕司, 趙芫, 趙松吉, 志賀哲, 黒田敏, 佐治英郎, 玉木長良

    日本血栓止血学会誌   20 ( 2 )   179   2009

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  • 一体型小動物用PET/SPECT/CT装置の性能評価

    孫田惠一, 孫田惠一, 久保直樹, 鈴木幸太郎, 西嶋剣一, 趙松吉, 久下裕司, 玉木長良

    核医学   46 ( 3 )   S271-S272   2009

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  • 分子イメージング技術を用いた糖鎖修飾GLP‐1の組織分布解析

    渡邊郁剛, 渡邊郁剛, 西嶋剣一, 趙松吉, 鈴木幸太郎, 伊藤剛, 武本浩, 玉木長良, 久下裕司

    日本薬学会年会要旨集   129th ( 4 )   217   2009

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  • ヒト癌細胞移植マウスにおける抗VEGF抗体(Bevacizumab)による分子標的療法:FLTを用いた早期治療効果評価

    趙松吉, 久下裕司, 趙芫, 竹内啓, 波多野利行, 西嶋剣一, 木下一郎, 秋田弘毅, 玉木長良

    核医学   46 ( 3 )   S260-S261   2009

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  • 肉芽腫・腫瘍の鑑別診断におけるdynamic &lt;sup&gt;11&lt;/sup&gt;C‐MET‐PETの有用性:小動物用PETを用いた基礎的検討

    趙松吉, 久下裕司, 伊敏, 趙芫, 竹内啓, 波多野利行, 鈴木幸太郎, 孫田惠一, 西嶋剣一, 小華和柾志, 玉木長良

    核医学   46 ( 3 )   S271   2009

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  • チミジンホスホリラーゼ標的イメージング剤の合成とその有用性に関する基礎的評価

    大倉一枝, 高橋正幸, 西嶋剣一, 趙松吉, 秋澤宏行, 久下裕司, 玉木長良, 関興一

    核医学   45 ( 3 )   S232   2008

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  • 核医学による動脈硬化イメージング

    久下裕司, 趙芫, 趙松吉, 志賀哲, 黒田敏, 佐治英郎, 玉木長良

    日本血栓止血学会誌   20 ( 2 )   179   2009

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  • 小動物用PET/SPECT/CT装置InveonのSPECT部の性能評価

    孫田惠一, 久保直樹, 鈴木幸太郎, 趙松吉, 久下裕司, 玉木長良

    核医学   45 ( 3 )   S213   2008

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  • 分子イメージング技術を用いた糖鎖修飾GLP‐1の組織分布解析

    渡邊郁剛, 渡邊郁剛, 西嶋剣一, 趙松吉, 鈴木幸太郎, 伊藤剛, 武本浩, 玉木長良, 久下裕司

    日本薬学会年会要旨集   129th ( 4 )   217   2009

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  • 動脈硬化病変における&lt;sup&gt;99m&lt;/sup&gt;Tc‐annexin A5/&lt;sup&gt;14&lt;/sup&gt;C‐FDG集積:病理的評価との比較

    趙芫, 久下裕司, 趙松吉, 吉永恵一郎, 玉木長良

    核医学   45 ( 3 )   S173   2008

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  • SNM2009報告.

    玉木長良、 志賀 哲、 趙 松吉、 久下裕司

    PET Journal   ( 7 )   48 - 49   2009

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  • Rhodococcus肉芽腫とラットglioma腫瘍ラットモデルにおけるFDG集積の比較検討

    趙松吉, 趙松吉, 久下裕司, 趙芫, 鐘ケ江香久子, 関興一, 玉木長良

    核医学   45 ( 3 )   S224   2008

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  • 多発性骨髄腫における全身methionine‐PETの有用性:FDG‐PETとの比較

    鐘ケ江香久子, 岡本祥三, 平田健司, 上林倫史, 趙松吉, 真鍋治, 久下裕司, 玉木長良

    核医学   45 ( 3 )   S221   2008

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  • チミジンホスホリラーゼ標的イメージング剤の合成とその有用性に関する基礎的評価

    大倉一枝, 高橋正幸, 西嶋剣一, 趙松吉, 秋澤宏行, 久下裕司, 玉木長良, 関興一

    核医学   45 ( 3 )   S232   2008

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  • 腫瘍血管新生イメージングのためのチミジンホスホリラーゼ標的放射性薬剤の開発

    高橋正幸, 関興一, 西嶋剣一, 趙松吉, 秋澤宏行, 久下裕司, 玉木長良, 大倉一枝

    バイオメディカル分析科学シンポジウム講演要旨集   21st   133 - 134   2008

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  • 小動物用PET/SPECT/CT装置InveonのSPECT部の性能評価

    孫田惠一, 久保直樹, 鈴木幸太郎, 趙松吉, 久下裕司, 玉木長良

    核医学   45 ( 3 )   S213   2008

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  • チミジンホスホリラーゼ標的SPECT薬剤の合成

    高橋正幸, 趙松吉, 西嶋剣一, 久下裕司, 関興一, 大倉一枝

    日本薬学会年会要旨集   128th ( 4 )   71   2008

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  • 動脈硬化病変における&lt;sup&gt;99m&lt;/sup&gt;Tc‐annexin A5/&lt;sup&gt;14&lt;/sup&gt;C‐FDG集積:病理的評価との比較

    趙芫, 久下裕司, 趙松吉, 吉永恵一郎, 玉木長良

    核医学   45 ( 3 )   S173   2008

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  • Rhodococcus肉芽腫とラットglioma腫瘍ラットモデルにおけるFDG集積の比較検討

    趙松吉, 趙松吉, 久下裕司, 趙芫, 鐘ケ江香久子, 関興一, 玉木長良

    核医学   45 ( 3 )   S224   2008

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  • 多発性骨髄腫に対するMET‐PETの有用性の検討‐FDG‐PETとの比較‐

    鐘ケ江香久子, 森田浩一, 岡本祥三, 真鍋治, 平田健司, 吉永恵一郎, 井上哲也, 趙松吉, 玉木長良

    核医学   44 ( 4 )   391   2007

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  • 多発性骨髄腫における全身methionine‐PETの有用性:FDG‐PETとの比較

    鐘ケ江香久子, 岡本祥三, 平田健司, 上林倫史, 趙松吉, 真鍋治, 久下裕司, 玉木長良

    核医学   45 ( 3 )   S221   2008

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  • 細胞増殖能評価,腫瘍‐肉芽腫の鑑別診断における&lt;sup&gt;11&lt;/sup&gt;C‐methionineと&lt;sup&gt;18&lt;/sup&gt;F‐FDGの比較

    趙松吉, 趙松吉, 久下裕司, 久下裕司, 趙芫, 竹井俊樹, 加藤誠一, 鐘ケ江香久子, 岡本祥三, 加藤千恵次, 関興一, 玉木長良

    核医学   44 ( 3 )   262   2007

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  • 腫瘍血管新生イメージングのためのチミジンホスホリラーゼ標的放射性薬剤の開発

    高橋正幸, 関興一, 西嶋剣一, 趙松吉, 秋澤宏行, 久下裕司, 玉木長良, 大倉一枝

    バイオメディカル分析科学シンポジウム講演要旨集   21st   133 - 134   2008

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  • 骨転移マーカー1CTPを用いた骨転移評価の役割―骨シンチグラフィ,FDG‐PETとの比較―

    鐘ケ江香久子, 真鍋治, 岡本祥三, 平田健司, 吉永恵一郎, 志賀哲, 趙松吉, 玉木長良

    核医学   44 ( 3 )   331   2007

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  • チミジンホスホリラーゼ標的SPECT薬剤の合成

    高橋正幸, 趙松吉, 西嶋剣一, 久下裕司, 関興一, 大倉一枝

    日本薬学会年会要旨集   128th ( 4 )   71   2008

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  • 塵肺合併肺癌の検出におけるFDG‐PET後期像追加の意義の検討

    鐘ケ江香久子, 志賀哲, 中野郁夫, 木村清延, 加地浩, 岡本祥三, 真鍋治, 趙松吉, 久下裕司, 玉木長良

    核医学   44 ( 3 )   255   2007

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  • 放射線治療を指向したPET/SPECTプローブの開発―低酸素イメージングを中心に―(第37回放射線による制癌シンポジウム。

    久下 裕司、上田 真史、趙 松吉、工藤 喬、近藤 科江、田中 正太郎、玉木 長良、平岡 眞寛、佐治 英郎

    癌の臨床 Jpn J Cancer Clin   54 ( 2 )   105 - 108   2008

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  • &lt;sup&gt;3&lt;/sup&gt;H‐FLTによる癌の分子標的療法の早期評価:担がんマウスにおける投与量依存性の検討

    趙松吉, 趙松吉, 久下裕司, 久下裕司, 趙芫, 竹井俊樹, 鐘ケ江香久子, 犬伏正幸, 志賀哲, 加藤千恵次, 関興一, 玉木長良

    核医学   44 ( 3 )   294   2007

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  • ApoE-/-マウスの動脈硬化病変における脂質沈着と&lt;sup&gt;18&lt;/sup&gt;F‐FDG/&lt;sup&gt;99m&lt;/sup&gt;Tc‐annexinA5集積との関連

    趙芫, 久下裕司, 久下裕司, 趙松吉, 犬伏正幸, 森田浩一, 玉木長良

    核医学   44 ( 3 )   261   2007

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  • 多発性骨髄腫に対するMET‐PETの有用性の検討‐FDG‐PETとの比較‐

    鐘ケ江香久子, 森田浩一, 岡本祥三, 真鍋治, 平田健司, 吉永恵一郎, 井上哲也, 趙松吉, 玉木長良

    核医学   44 ( 4 )   391   2007

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  • 半導体検出器を用いたPET画像診断の展望

    志賀哲, 森本裕一, 上野雄一郎, 雨宮健介, 久保直樹, 趙松吉, 玉木長良

    Isot News   ( 641 )   2 - 6   2007

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  • 細胞増殖能評価,腫瘍‐肉芽腫の鑑別診断における&lt;sup&gt;11&lt;/sup&gt;C‐methionineと&lt;sup&gt;18&lt;/sup&gt;F‐FDGの比較

    趙松吉, 趙松吉, 久下裕司, 久下裕司, 趙芫, 竹井俊樹, 加藤誠一, 鐘ケ江香久子, 岡本祥三, 加藤千恵次, 関興一, 玉木長良

    核医学   44 ( 3 )   262   2007

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  • 分子イメージングとがん治療戦略:イメージングによるインビボ組織染色を目指して

    久下裕司, 佐治英郎, 玉木長良, 趙松吉, 関興一, 上田真史, 清野泰, 清野泰

    Innervision   22 ( 7 )   42   2007

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  • 骨転移マーカー1CTPを用いた骨転移評価の役割―骨シンチグラフィ,FDG‐PETとの比較―

    鐘ケ江香久子, 真鍋治, 岡本祥三, 平田健司, 吉永恵一郎, 志賀哲, 趙松吉, 玉木長良

    核医学   44 ( 3 )   331   2007

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  • 塵肺合併肺癌の検出におけるFDG‐PET後期像追加の意義の検討

    鐘ケ江香久子, 志賀哲, 中野郁夫, 木村清延, 加地浩, 岡本祥三, 真鍋治, 趙松吉, 久下裕司, 玉木長良

    核医学   44 ( 3 )   255   2007

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  • 半導体検出器を使用した小被写体用PET装置の基本性能とその評価について

    久保直樹, 加藤千恵次, 玉木長良, 趙松吉, 森本裕一, 上野雄一郎, 北口博司, 土屋一俊, 小嶋進一, 梅垣菊男

    核医学   43 ( 4 )   343   2006

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  • &lt;sup&gt;3&lt;/sup&gt;H‐FLTによる癌の分子標的療法の早期評価:担がんマウスにおける投与量依存性の検討

    趙松吉, 趙松吉, 久下裕司, 久下裕司, 趙芫, 竹井俊樹, 鐘ケ江香久子, 犬伏正幸, 志賀哲, 加藤千恵次, 関興一, 玉木長良

    核医学   44 ( 3 )   294   2007

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  • PETを用いた塵肺の評価―FDGとMETの比較―

    鐘ケ江香久子, 志賀哲, 趙松吉, 玉木長良, 中野郁夫, 木村清信, 加地浩

    核医学   43 ( 4 )   333   2006

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  • ApoE-/-マウスの動脈硬化病変における脂質沈着と&lt;sup&gt;18&lt;/sup&gt;F‐FDG/&lt;sup&gt;99m&lt;/sup&gt;Tc‐annexinA5集積との関連

    趙芫, 久下裕司, 久下裕司, 趙松吉, 犬伏正幸, 森田浩一, 玉木長良

    核医学   44 ( 3 )   261   2007

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  • ApoE‐/‐及び対照マウスの動脈組織への&lt;sup&gt;18&lt;/sup&gt;F‐FDG及び&lt;sup&gt;99m&lt;/sup&gt;Tc‐annexin A5の集積:高脂肪食による経時的変化

    趙芫, 久下裕司, 久下裕司, 趙松吉, 犬伏正幸, 森田浩一, 玉木長良

    核医学   43 ( 3 )   230   2006

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  • 半導体検出器を用いたPET画像診断の展望

    志賀哲, 森本裕一, 上野雄一郎, 雨宮健介, 久保直樹, 趙松吉, 玉木長良

    Isot News   ( 641 )   2 - 6   2007

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  • &lt;sup&gt;11&lt;/sup&gt;C‐methionine(MET)の腫瘍・肉芽腫への集積性の違い:&lt;sup&gt;18&lt;/sup&gt;F‐FDG及び&lt;sup&gt;18&lt;/sup&gt;F‐FLTとの比較

    趙松吉, 久下裕司, 久下裕司, 竹井俊樹, 趙芫, 加藤誠一, 鐘ケ江香久子, 犬伏正幸, 森田浩一, 関興一, 玉木長良

    核医学   43 ( 3 )   249   2006

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  • 分子イメージングとがん治療戦略:イメージングによるインビボ組織染色を目指して

    久下裕司, 佐治英郎, 玉木長良, 趙松吉, 関興一, 上田真史, 清野泰, 清野泰

    Innervision   22 ( 7 )   42   2007

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  • 半導体検出器が装備された小視野PET装置の基礎的検討

    久保直樹, 趙松吉, 加藤千恵次, 上野雄一郎, 森本裕一, 雨宮健介, 梅垣菊男, 犬伏正幸, 玉木長良

    核医学   43 ( 3 )   244   2006

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  • 半導体検出器を用いたPET画像診断の展望。

    志賀 哲、森本 裕一、上野 雄一郎、雨宮 健介、久保 直樹、趙 松吉、玉木 長良

    ISOTOPE NEWS   641 ( 9 )   2 - 6   2007

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  • &lt;sup&gt;3&lt;/sup&gt;H‐FLTを用いた癌の分子標的療法(Iressa)の早期治療効果の評価

    趙松吉, 久下裕司, 久下裕司, 竹井俊樹, 趙芫, 加藤誠一, 鐘ケ江香久子, 犬伏正幸, 森田浩一, 関興一, 玉木長良

    核医学   43 ( 3 )   221   2006

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  • 分子イメージングとがん治療戦略:イメージングによるインビボ組織染色を目指して。

    久下 裕司、佐治 英郎、玉木 長良、趙 松吉、関 興一、上田 真史、清野 泰

    INNERVISION   22 ( 7 )   17   2007

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  • 半導体検出器を使用した小被写体用PET装置の基本性能とその評価について

    久保直樹, 加藤千恵次, 玉木長良, 趙松吉, 森本裕一, 上野雄一郎, 北口博司, 土屋一俊, 小嶋進一, 梅垣菊男

    核医学   43 ( 4 )   343   2006

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  • PETを用いた塵肺の評価―FDGとMETの比較―

    鐘ケ江香久子, 志賀哲, 趙松吉, 玉木長良, 中野郁夫, 木村清信, 加地浩

    核医学   43 ( 4 )   333   2006

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  • ApoE‐/‐及び対照マウスの動脈組織への&lt;sup&gt;18&lt;/sup&gt;F‐FDG及び&lt;sup&gt;99m&lt;/sup&gt;Tc‐annexin A5の集積:高脂肪食による経時的変化

    趙芫, 久下裕司, 久下裕司, 趙松吉, 犬伏正幸, 森田浩一, 玉木長良

    核医学   43 ( 3 )   230   2006

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  • &lt;sup&gt;11&lt;/sup&gt;C‐methionine(MET)の腫瘍・肉芽腫への集積性の違い:&lt;sup&gt;18&lt;/sup&gt;F‐FDG及び&lt;sup&gt;18&lt;/sup&gt;F‐FLTとの比較

    趙松吉, 久下裕司, 久下裕司, 竹井俊樹, 趙芫, 加藤誠一, 鐘ケ江香久子, 犬伏正幸, 森田浩一, 関興一, 玉木長良

    核医学   43 ( 3 )   249   2006

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  • 半導体検出器が装備された小視野PET装置の基礎的検討

    久保直樹, 趙松吉, 加藤千恵次, 上野雄一郎, 森本裕一, 雨宮健介, 梅垣菊男, 犬伏正幸, 玉木長良

    核医学   43 ( 3 )   244   2006

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    Language:Japanese   Publishing type:Research paper (other academic)  

  • &lt;sup&gt;3&lt;/sup&gt;H‐FLTを用いた癌の分子標的療法(Iressa)の早期治療効果の評価

    趙松吉, 久下裕司, 久下裕司, 竹井俊樹, 趙芫, 加藤誠一, 鐘ケ江香久子, 犬伏正幸, 森田浩一, 関興一, 玉木長良

    核医学   43 ( 3 )   221   2006

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    Language:Japanese   Publishing type:Research paper (other academic)  

  • FDG-PETによる炎症病変診断法の開発:膜輸送遺伝子,病理組織学的検討。

    玉木 長良、小華和 征志、趙 松吉

    INNERVISION   21 ( 7 )   17   2006

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    Language:Japanese   Publishing type:Research paper (other academic)  

  • FDG-PET検査の改良による腫瘍の鑑別診断法の開発:膜輸送遺伝子による検討。

    玉木 長良、久下 裕司、趙 松吉、塚本江利子、中駄 邦博

    INNERVISION   18 ( 8 )   25   2003

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    Language:Japanese   Publishing type:Research paper (other academic)  

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Books

  • In: Molecular Imaging for Integrated Medical Therapy and Drug Development

    Kuge Y, Shiga T, Tamaki N eds.(Semiconductor detector-based scanner for nuclear medicine)

    Springer (Springer Science+Business Media), Heidelberger  2016 

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    Responsible for pages:51-65   Language:English  

    Authors name of the chapter and paper which it took charge of:Takeuchi W, Suzuki A, Ueno Y, Shiga T, Hirata K, Okamoto S, Zhao S, Kuge Y, Kubo N, Kobayashi K, Watanabe S, Kobashi K, Umegaki K, Tamaki N.   Publication place:  

  • In: Prespectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy (Kuge Y, Shiga T, Tamaki N eds.)

    Kuge Y, Shiga T, Tamaki N eds.(Preclinical evaluation of a thymidine phosphorylase imaging probe, [123I]IIMU, for the translational research)

    Springer (Springer Science+Business Media), Heidelberger  2016 

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    Responsible for pages:125-130   Language:English  

    Authors name of the chapter and paper which it took charge of:Nishijima K, Zhao S, Ohkura K, Tamaki N, Kuge Y   Publication place:  

  • In: Prespectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy (Kuge Y, Shiga T, Tamaki N eds.)

    Kuge Y, Shiga T, Tamaki N eds.(Discovery and Evaluation of Biomarkers for Atherosclerosis Differential Proteomic of Plasma and Tissues)

    Springer (Springer Science+Business Media), Heidelberger  2016 

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    Responsible for pages:131-139   Language:English  

    Authors name of the chapter and paper which it took charge of:Sakamoto T, Hanzawa H, Manri N, Sakakibara M, Shimizu Y, Zhao Y, Zhao S, Yamada S, Kamiya K, Eki Y, Suzuki A, Higuchi H, Sugano C, Tsutsui H, Tamaki N, Kuge Y   Publication place:  

  • In: Prespectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy (Kuge Y, Shiga T, Tamaki N eds.)

    Kuge Y, Shiga T, Tamaki N eds.(Radioimmunodetection of Atherosclerotic Lesions Focusing on the Accumulation Mechanism of Immunoglobulin G.)

    Springer (Springer Science+Business Media), Heidelberger  2016 

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    Responsible for pages:141-150   Language:English  

    Authors name of the chapter and paper which it took charge of:Shimizu Y, Hanzawa H, Zhao Y, Nishijima K, Fukura S, Sakamoto T, Zhao S, Tamaki N, Kuge Y   Publication place:  

  • Molecular Imaging for the Assessment of Tumor Malignancy and Response to Therapy. In: Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.).

    (Molecular Imaging of Atherosclerotic Plaque Vulnerability: Comparison between 18F-FDG and 99mTc-Annexin A5.)

    2010 

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    Responsible for pages:19-29   Language:English  

    Authors name of the chapter and paper which it took charge of:Kuge Y, Zhao S, Takei T, Tamaki N   Publication place:  

  • Molecular Imaging for the Assessment of Tumor Malignancy and Response to Therapy. In:Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.).

    (Initial Performance Measurement of an Integrated PET/SPECT/CT System for Small Animal Imaging.)

    2010 

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    Responsible for pages:30-41   Language:English  

    Authors name of the chapter and paper which it took charge of:Morimoto Y, Ueno Y, Kojima S, Takeuchi W, Ishitsu T, Matsuzaki K, Umegaki K, Kubo N, Katoh C, Zhao S, Shiga T, Tamaki N.   Publication place:  

  • Molecular Imaging for the Assessment of Tumor Malignancy and Response to Therapy. In:Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.).

    (Development of a prototype 3D PETscanner using semiconductor detectors and depth of interaction information.)

    2010 

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    Responsible for pages:60-68   Language:English  

    Authors name of the chapter and paper which it took charge of:Magota K, Kubo N, Narihiro K, Suzuki K, Nishijima K, Zhao S, Kuge Y, Tamaki N:   Publication place:  

  • Molecular Imaging for the Assessment of Tumor Malignancy and Response to Therapy. In: Molecular Imaging for Integrated Medical Therapy and Drug Development (Tamaki N, Kuge Y eds.).

    (Molecular Imaging of Atherosclerotic Plaque Vulnerability: Comparison between 18F-FDG and 99mTc-Annexin A5)

    Springer (Springer Science+Business Media), Heidelberger  2010 

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    Responsible for pages:66-77   Language:English  

    Authors name of the chapter and paper which it took charge of:Zhao Y, Kuge Y, Zhao S, Strauss HW, Blankenberg FG, Tamaki N:   Publication place:  

  • In: PET and Molecular Imaging: State of the art and future perspectives.

    (Time course of apoptotic tumor response using 99mTc-annexin V following a single dose of chemotherapy: comparison with immunohistological findings in an experimental animal model.)

    2004 

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    Responsible for pages:249-252   Language:English  

    Authors name of the chapter and paper which it took charge of:Takei T, Kuge Y, Zhao S, Mochizuki T, Strauss HW, Blankenberg FG, Tait JF, Tamaki N   Publication place:  

  • In: PET and Molecular Imaging: State of the art and future perspectives (Tamaki N, Kuge Y eds.)

    (An ultra-high-energy collimator for small animal imaging in dula-isotope study of 18F and 99mTc)

    2004 

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    Responsible for pages:275-279   Language:English  

    Authors name of the chapter and paper which it took charge of:Kubo N, Zhao S, Kinda A, Motomura N, Katoh C, Kuge Y, Tamaki N   Publication place:  

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Presentations

  • Possibility of 123I-meta-iodobenzylguanidine (MIBG) as companion diagnostic drug for therapeutic alpha-emitting meta-211At-astato-benzylguanidine (211At-MABG) in normal and pheocheomocytoma xenograft mice

    SNMMI2023 Annual Meeting   2023.6  

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    Event date: 2023.6

  • 日本のアスタチン‐211を用いた標的α線治療開発の現状と福島県立医科大学の取組

    笹川医学奨学金進修生同学会日本支部2022年度総会・学術セミナー   2023.3  

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    Event date: 2023.3

  • Current Status and Future Prospects of Preclinical Development of Targeted Alpha Particle Therapy using 211At at Fukushima Medical University

    2023.1  

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    Event date: 2023.1

  • Similarities and differences of dosimetry between meta-[211At]astatobenzylguanidine (211At-MABG) and meta-[123I]iodobenzylguanidine (123I-MIBG) as companion diagnostic drug in PC12 pheochromocytoma model mice

    EANM'22 - Annual Congress of the European Association of Nuclear Medicine   2022.10  

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    Event date: 2022.10

  • 低免疫原性ストレプトアビジン変異体と改変ビオチンを用いるプレターゲティングシステムの開発

    日本放射線化学会第66回討論会(2022)   2022.9  

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    Event date: 2022.9

  • 悪性褐色細胞腫PC12移植マウスにおける123I-MIBGイメージングとex-vivo体内動態及び線量評価の比較

    第62回日本核医学会学術総会   2022.9  

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    Event date: 2022.9

  • Imaging of 5-HT2A receptors in rats with semi-chronic administration of phencyclidine

    NEURO 2022   2022.7  

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    Event date: 2022.6 - 2022.7

  • Effects of single and repeated 211At-MABG treatments on tumor growth suppression in a pheochromocytoma xenograft

    SNMMI2022 Annual Meeting   2022.6  

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    Event date: 2022.6

  • Synthesis and evaluation of 211At-labeled bis-iminobiotin for pretargeted alpha radioimmunotherapy

    SNMMI2022 Annual Meeting   2022.6  

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    Event date: 2022.6

  • 急性骨髄性白血病における211At標識抗CD82抗体の治療効果

    第3回放射線災害・医科学研究拠点ワークショップ   2022.2  

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    Event date: 2022.2

  • 急性骨髄性白血病における211At標識抗CD82抗体の治療効果

    第61回日本核医学会学術総会   2021.11  

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    Event date: 2021.11

  • 悪性褐⾊細胞腫PC12移植マウスにおける123I-MIBGと211At-MABGの体内動態及び線量評価

    第61回日本核医学会学術総会   2021.11  

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    Event date: 2021.11

  • Correlation of radiotoxicity and dosimetry of 211At-MABG in normal mice.

    第61回日本核医学会学術総会   2021.11  

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    Event date: 2021.11

  • 高齢マウスの局所脳糖代謝に対する人参栄養湯の効果:インシュリン負荷による18F-FDG オートラジオグラフィーの画像手法を用いた評価

    第61回日本核医学会学術総会   2021.11  

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    Event date: 2021.11

  • 第1相試験に向けた211At-MABGの⾮臨床開発戦略

    第61回日本核医学会学術総会   2021.11  

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    Event date: 2021.11

  • 正常マウスにおけるフリー 211Atの臓器毒性評価

    第61回日本核医学会学術総会   2021.11  

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    Event date: 2021.11

  • 褐色細胞腫モデルにおける211At-MABGの反復投与による腫瘍成長の抑制効果の評価

    第61回日本核医学会学術総会   2021.11  

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    Event date: 2021.11

  • ヒト急性白血病モデルマウスにおける211At-CD33の体内動態

    第61回日本核医学会学術総会   2021.11  

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    Event date: 2021.11

  • ヒト急性白血病モデルマウスにおける211At-CD82の体内動態

    第61回日本核医学会学術総会   2021.11  

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    Event date: 2021.11

  • Evaluation of acute radiotoxicity profile of alpha-particle-emitting meta-211At-astato-benzylguanidine (211At-MABG) in normal BALB/c mice

    SNMMI2021 Annual Meeting   2021.6  

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    Event date: 2021.6

  • Evaluation of effect of Ninjin'yoeito on regional brain glucose metabolism by 18F-FDG autoradiography with insulin loading in superaged mice

    SNMMI2021 Annual Meeting   2021.6  

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    Event date: 2021.6

  • Effect of the targeted alpha therapy using mutant streptavidin bisiminobiotin pre-targeting system in a human gastric cancer cell xenograft

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    Event date: 2020.11

  • Synthesis of bis-iminobiotin derivatives and labeling with Astatine-211

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    Event date: 2020.11

  • Biodistribution studies of 211At labeled bis-iminobiotins for pretargeting radionuclide therapy

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    Event date: 2020.11

  • Optimization for pre-targeted radionuclide therapy using 211At labeled bis-iminobiotin

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    Event date: 2020.11

  • Similarities and differences of dosimetry between meta-[211At]astatobenzylguanidine (211At-MABG) and meta-[123I]iodobenzylguanidine (123I-MIBG) as companion diagnostic drug

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    Event date: 2020.11

  • Acute dose response of hemato-toxicity of 211At-MABG in normal mice

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    Event date: 2020.11

  • Effects and safety of alpha-emitting meta-211At-astato-benzylguanidine (211At-MABG) comparison with 131I-meta-iodobenzylguanidine (131I-MIBG) in a pheochromocytoma mouse model

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    Event date: 2020.11

  • Preclinical Evaluation of Radiotoxicity of 211At-MABG in normal mice.

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    Event date: 2020.11

  • Biodistribution and dosimetry studies for the optimization of pre-targeted radionuclide therapy using 211At-labeled modified biotin.

    EANM'20 - Annual Congress of the European Association of Nuclear Medicine  

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    Event date: 2020.10

  • Evaluation of therapeutic effect of the targeted alpha therapy using Cupid-211At-labeled Psyche-B pretargeting system in a human gastric cancer cell xenograft.

    EANM'20 - Annual Congress of the European Association of Nuclear Medicine  

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    Event date: 2020.10

  • Search for the optimal bis-iminobiotin for the pretargeting strategy using a mutated low immunogenic streptavidin.

    EANM'20 - Annual Congress of the European Association of Nuclear Medicine  

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    Event date: 2020.10

  • Comparative evaluation of radiation dosimetry between meta-[211At]astatobenzylguanidine (211At-MABG) and meta-[123I]iodobenzylguanidine (123I-MIBG)

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    Event date: 2020.10

  • α放射体211At標識イミノビオチンの作成と安定性評価

    日本放射線影響学会第63回大会  

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    Event date: 2020.10

  • Differences and similarities in biodistribution, pharmacokinetics and metabolites of 211At-MABG versus 123I-MIBG in normal mice.

    Society of Nuclear Medicine Annual Meeting (SNMMI 2020)  

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    Event date: 2020.7

  • Effects and safety of alpha-emitting meta-211At-astato-benzylguanidine (211At-MABG) compared with 131I-meta-iodobenzylguanidine (131I-MIBG) on tumor growth suppression in a pheochromocytoma mouse model.

    Society of Nuclear Medicine Annual Meeting (SNMMI 2020)  

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    Event date: 2020.7

  • Feasibility of cancer stem cells-targeted radioimmunotherapy for acute myelogenous leukemia with 211At-CXCR4 monoclonal antibody.

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    Event date: 2020.7

  • Development of a low immunogenic mutated streptavidin pretargeting strategy with 211At labeled modified biotin for advanced cancer treatment.

    Society of Nuclear Medicine Annual Meeting (SNMMI 2020)  

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    Event date: 2020.7

  • Effects of alpha-emitting meta-211At-astato-benzylguanidine (211At-MABG) compared to 131I-meta-iodobenzylguanidine (131I-MIBG) on tumor growth suppression in a pheochromocytoma mouse model.

    The Endocrine Society's 102nd Annual Meeting (ENDO2020)  

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    Event date: 2020.3

  • Delta-like 1 homolog (DLK-1)を標的した治療開発および臨床的意義の検討

    第60回日本肺癌学会学術集会  

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    Event date: 2019.12

  • Delta-like 1 homolog (DLK-1)を標的した治療開発および臨床的意義

    第32回日本バイオセラピィ学会学術集会総会  

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    Event date: 2019.11

  • Search for TLC procedure of meta-[211At]astatobenzylguanidine ([211At]MABG)

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    Event date: 2019.11

  • 211At-MABG dosimetry using 123I-MIBG as companion diagnostic drug in normal mice

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    Event date: 2019.11

  • Preliminary evaluation on pharmacokinetics and metabolites of 211At-MABG in normal mice

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    Event date: 2019.11

  • An effort to diagnostic and therapeutic nuclear medicine at Fukushima Medical University using two medical cyclotrons

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    Event date: 2019.10

  • An effort to diagnostic and therapeutic nuclear medicine at Fukushima Medical University using two medical cyclotrons.

    International Symposium on Traends in Radiopharmaceuticals (ISTR 2019)  

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    Event date: 2019.10

  • Delta-like 1 homolog (DLK1) expression in non-small-cell lung cancer and the development of radioimmunotherapy targeting DLK1

    World Coference on Lung Cancer (WCLC 2019)  

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    Event date: 2019.9

  • Evaluation of the potential of organ glucose metabolism by 18F-FDG accumulation with insulin loading in older mice compared with younger normal mice

    The 66th Society of Nuclear Medicine Annual Meeting (SNMMI 2019)  

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    Event date: 2019.6

  • Possibility of 123I-meta-iodobenzylguanidine (123I-MIBG) as companion diagnostic drug for therapeutic alpha-emitting meta-211At-astato-benzylguanidine (211At-MABG)

    The 66th Society of Nuclear Medicine Annual Meeting (SNMMI 2019)  

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    Event date: 2019.6

  • Synthesis of [211At]MABG Using Remote-controlled Synthesizer and Quality Evaluation

    The ISRS 2019  

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    Event date: 2019.5

  • Biodistribution and dosimetry of Free and meta-[211At]astatobenzylguanidine (MABG) in normal mice

    The 11th International Symposium on TargetedAlpha-Therapy (TAT11)  

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    Event date: 2019.4

  • Manufacture of [211At]MABG Using Remote-controllable Synthesizer and Quality Evaluation

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    Event date: 2019.3

  • Evaluation of the distribution of At-211 solution dispersion in the small an imal cage

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    Event date: 2018.11

  • Dosimetry of free 211At and meta-[211At]astatobenzylguanidine (MABG) in normal mice

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    Event date: 2018.11

  • Manufacture and Quality Evaluation Using Synthesizer of [211At]MABG

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    Event date: 2018.11

  • Is it possible to detect the contamination of At-211 using survey meter ?

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    Event date: 2018.11

  • Investigation of the influence of intratumoral glutathione status on the distribution of a hypoxic probe [18F]FMISO

    WFNMB 2018  

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    Event date: 2018.4

  • Preclinical evaluation of [18F]DiFA, a novel PET probe for tumor hypoxia, in comparison with [18F]MISO

    The 64rd Society of Nuclear Medicine Annual Meeting (SNMMI 2017)  

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    Event date: 2017.6

  • Effect of eribulin on remodeling of tumor vasculature confirmed by FMISO PET imaging-Small-animal PET study in human breast cancer cell xenograft

    The 64rd Society of Nuclear Medicine Annual Meeting (SNMMI 2017)  

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    Event date: 2017.6

  • The Production of 211At at Fukushima Medical University

    The 10th International Symposium on Targeted Alpha Therapy (TAT-10) in Kanazawa  

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    Event date: 2017.5

  • Production of At-211 by In-house Cyclotron and Characterization at Fukushima Medical University

    The 76th Annual Meeting of the Japan Radiological Society  

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    Event date: 2017.4

  • Inflammatory Changes in Brain and Lymphoid Organs after Ischemic Stroke: PET Imaging for Cell Therapy

    the International Stroke Conference 201T  

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    Event date: 2017.2

  • Current Status and Future Prospects of Molecular Imaging and Targeted Radionuclide Therapy in Fukushima Medical University

    Asian Forum for Accelerators and Detectors (AFAD 2017)  

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    Event date: 2017.1

  • Current Status and Future Prospects of Molecular Imaging and Targeted Radionuclide Therapy in Fukushima Medical University

    Asian Forum for Accelerators and Detectors (AFAD 2017)  

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    Event date: 2017.1

  • FMISO PETイメージングによるeribulinの低酸素解除作用の実証:小動物PETと乳癌モデルを用いた検討

    第56回日本核医学学術総会  

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    Event date: 2016.11

  • FMISO PETイメージングによるeribulinの腫瘍内低酸素状態解除作用の評価

    第31回福島県核医学研究会  

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    Event date: 2016.9

  • FMISO PETイメージングによるeribulinの腫瘍内低酸素状態解除作用の実証―小動物用PETと乳癌モデルを用いた検討―

    第12回小動物インビボイメージング研究会  

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    Event date: 2016.7

  • Effects of eribulin on remodeling of tumor vasculature evaluated with FMISO hypoxia imaging in a human breast cancer cell xenograft

    The 63rd Society of Nuclear Medicine Annual Meeting (SNMMI 2016)  

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    Event date: 2016.6

  • Does FMISO-PET really visualize only hypoxic states?; accumulation mechanism assessment of FMISO in hypoxic cells in combination with mass spectrometry

    The 63rd Society of Nuclear Medicine Annual Meeting (SNMMI 2016)  

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    Event date: 2016.6

  • Metabolic Aspects of [14C]Acetete in Rabbit Atherosclerotic Arteries at Different Feeding Conditions: In Vitro Evaluation for Atherosclerosis Imaging with [11C]Acetate

    The 63rdSociety of Nuclear Medicine Annual Meeting (SNMMI 2016)  

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    Event date: 2016.6

  • Effects of eribulin on remodeling of tumor vascular evaluated with FMISO hypoxia imaging in a human breast cancer cell xenograft

    The 63rd Society of Nuclear Medicine Annual Meeting  

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    Event date: 2016.6

  • Effects of eribulin on remodeling of tumor vasculature evaluated with FMISO hypoxia imaging in a human breast cancer cell xenograft

    The 63rd Society of Nuclear Medicine Annual Meeting (SNMMI 2016)  

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    Event date: 2016.6

  • Effects of eribulin on remodeling of tumor vascular evaluated with FMISO hypoxia imaging in a human breast cancer cell xenograft

    The 63rd Society of Nuclear Medicine Annual Meeting  

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    Event date: 2016.6

  • Metabolic Aspects of [14C]Acetete in Rabbit Atherosclerotic Arteries at Different Feeding Conditions: In Vitro Evaluation for Atherosclerosis Imaging with [11C]Acetate

    The 63rdSociety of Nuclear Medicine Annual Meeting (SNMMI 2016)  

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    Event date: 2016.6

  • Does FMISO-PET really visualize only hypoxic states?; accumulation mechanism assessment of FMISO in hypoxic cells in combination with mass spectrometry

    The 63rd Society of Nuclear Medicine Annual Meeting (SNMMI 2016)  

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    Event date: 2016.6

  • 肺癌細胞移植モデルに対するマルチキナーゼ阻害剤sorafenib治療後の腫瘍増殖能変化のFLTによる評価

    日本分子イメージング学会第11回総会・学術集会  

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    Event date: 2016.5

  • 肺癌細胞移植モデルに対するマルチキナーゼ阻害剤sorafenib治療後の腫瘍増殖能変化のFLTによる評価

    日本薬学会第136年会  

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    Event date: 2016.3

  • 北海道大学核医学分子影像研究的现状与展望

    第5回JSPS中国同窓会・学術セミナー  

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    Event date: 2015.11

  • Preclinical Translational Researches of Novel PET and SPECT Tracers: 18F-FDiFA and 123I-IIMU for Hypoxia and Thymidine Phosphorylase Imaging

    The Asia Oceania Federation of Nuclear Medicine and Biology (AOFNMB) 2015  

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    Event date: 2015.10 - 2015.11

  • Preclinical Translational Researches of Novel PET and SPECT Tracers: 18F-FDiFA and 123I-IIMU for Hypoxia and Thymidine Phosphorylase Imaging

    The Asia Oceania Federation of Nuclear Medicine and Biology (AOFNMB) 2015  

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    Event date: 2015.10

  • Preclinical Translational Researches of Novel PET and SPECT Tracers: 18F-FDiFA and 123I-IIMU for Hypoxia and Thymidine Phosphorylase Imaging

    The Asia Oceania Federation of Nuclear Medicine and Biology (AOFNMB) 2015  

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    Event date: 2015.10

  • Dynamic PET evaluation of the increased FLT accumulation after sorafenib treatment in mice bearing a human renal cell carcinoma xenograft

    The 2015 World Molecular Imaging Congress  

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    Event date: 2015.9

  • 骨髄間質細胞移植は脳梗塞後の局所糖代謝を改善する―小動物用PET/CTによる検討

    その他の会議  

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    Event date: 2012

  • Preclinical evaluation of thymidine phosphorylase imaging probe, [123I]IIMU, A road to First-in-human clinical study

    Ninth Japan-China Joint Seminar on Radiopharmaceutical Chemistry (JCSRC 2015)  

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    Event date: 2015.11

  • イメージング質量分析法(IMS)による低酸素イメージング剤”FMISO”の腫瘍内代謝・集積機序の経時的評価

    第55回日本核医学会学術総会  

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    Event date: 2015.11

  • 14C-酢酸の家兎動脈硬化病変への集積機序:11C-酢酸による動脈硬化イメージングのための基礎的検討。

    第55回日本核医学会学術総会  

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    Event date: 2015.11

  • Eribulinの低酸素解除作用のFMISO低酸素イメージングを用いたヒト乳癌癌移植モデルにおける評価

    第55回日本核医学学術総会  

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    Event date: 2015.11

  • Preclinical Translational Researches of Novel PET and SPECT Tracers: 18F-FDiFA and 123I-IIMU for Hypoxia and Thymidine Phosphorylase Imaging

    The Asia Oceania Federation of Nuclear Medicine and Biology (AOFNMB) 2015  

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    Event date: 2015.10

  • Study of accumulation mechanism of hypoxia imaging probe “FMISO" in tumors by imaging mass spectrometry: A possible involvement of low-molecular metabolites

    The 2015 World Molecular Imaging Congress  

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    Event date: 2015.9

  • Dynamic PET evaluation of the increased FLT accumulation after sorafenib treatment in mice bearing a human renal cell carcinoma xenograft

    The 2015 World Molecular Imaging Congress  

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    Event date: 2015.9

  • Expression level of fatty acid-binding protein 5 increased in pro-inflammatory macrophage with atherosclerotic lesion formation; evaluation as a potential biomarker for atherosclerosis imaging

    The European Society of Cardiology (ESC) Congress 2015  

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    Event date: 2015.8

  • Sphigomyelin synthase 2 deficiency enhances glucose clearance and tissue uptake in mice

    The 14th International Conference on Bioactive Lipids in Cancer, Inflammation, and Related Diseases  

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    Event date: 2015.7

  • Thymidine phosphorylase (TP) expression in normal mice: comparison with biodistribution of a novel TP imaging probe

    The 62nd Society of Nuclear Medicine Annual Meeting  

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    Event date: 2015.6

  • Accumulation mechanism of non-targeted immunoglobulin G in atherosclerotic legions

    The 62nd Society of Nuclear Medicine Annual Meeting  

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    Event date: 2015.6

  • [111In-DTPA-D-Phe-1-Asp0-D-Phe1]-オクトレオチドの体内動態評価 : 放射能の腎集積性低減と腫瘍集積性の向上

    日本薬学会第135回年会  

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    Event date: 2015.3

  • イメージング質量分析(IMS)による低酸素イメージング剤“FMISO”の腫瘍内集積機序の検討:低分子代謝物の関与の可能性

    日本分子イメージング学会第10回総会・学術集会  

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    Event date: 2015.5

  • Dynamic 18F-FLT PETを用いた腎癌細胞移植モデルにおけるsorafenib治療後のFLT集積亢進過程の評価

    日本分子イメージング学会第10回総会・学術集会  

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    Event date: 2015.5

  • 動脈硬化病変への免疫グロブリンG集積機序の探索:動脈硬化診断用薬剤開発へ応用に関する基礎的検討

    第10回日本分子イメージング学会総会・学術総会  

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    Event date: 2015.5

  • 125I-BMIPPの肝臓への集積機序:食餌誘導性肥満マウスにおける検討

    その他の会議  

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    Event date: 2015

  • Hypoxia imaging with 18F-fluoromisonidazole for differentiating tumors from granulomas: a comparison with 18F-/14C-FDG in experimental rat models.

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    Event date: 2014

  • Effects of feeding conditions on the myocardial and hepatic accumulation of radioiodine-labeled BMIPP in mice.

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    Event date: 2014

  • Changes in tumor oxygen states after sorafenib therapy evaluated by using 18F-fluoromisonidazole hypoxia imaging in a renal cell cancer xenograft.

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    Event date: 2014

  • Evaluation of dynamic changes in tumor hypoxia and proliferation after radiotherapy in human head and neck cancer xenograft using dual tracers of FMISO and FLT.

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    Event date: 2014

  • Mechanisms of anti-tumor effects underlying sorafenib treatment: evaluation of tumor oxygen states using 18F-FMISO in a human lung cancer xenograft.

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    Event date: 2014

  • Increased metabolite levels of glycolysis and pentose phosphate pathway in rabbit atherosclerotic arteries and hypoxic macrophage.

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    Event date: 2014

  • Irbesartan reduces atherosclerosis in Watanabe Heritable Hyperlipidemic (WHHL) rabbits: Non-invasive imaging of inflammation with 18F-FDG PET

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    Event date: 2013

  • Effects of feeding conditions on the hepatic pharmacokinetics of radioiodine-labeled BMIPP in mice: Comparison with palmitic acid.

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    Event date: 2013

  • 核医学教育講演8「小動物イメージング‐様々なモダリティーの特徴と注意点~なぜ小動物イメージングが必要~」

    その他の会議  

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    Event date: 2014

  • Dose-dependent elevation of 18F-FDG concentration in the blood after ARB administration: Experiment in mice given telmisartan.

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    Event date: 2013

  • 頭頸部癌における放射線照射後の腫瘍増殖反応と腫瘍内低酸素状態の経時的変化:FLTとFMISOによる評価

    その他の会議  

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    Event date: 2014

  • FMISO PET reflects antiangiogenic tumor response after sorafenib treatment in human renal cell carcinoma xenograft.

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    Event date: 2013

  • 腎細胞癌モデルにおける18F-FMISOによる腫瘍内酸素状態の評価。

    その他の会議  

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    Event date: 2014

  • Sequential evaluation of intratumoral proliferative activity after radiotherapy by FLT in human head and neck cancer xenograft.

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    Event date: 2013

  • [125I]BMIPPのマウス心筋への取り込みにおよぼす摂餌状態の影響。

    その他の会議  

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    Event date: 2014

  • Radioiodinated BMIPP as a potential probe for hepatic fatty acid metabolism: evaluation in mice at different feeding status.

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    Event date: 2013

  • Hypoxia imaging with 18F-fluoromisonidazole for differentiating tumors from granulomas: a comparison with 18F-/14C-FDG in experimental rat models.

    その他の会議  

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    Event date: 2014

  • Monitoring tumor proliferative activity after radiotherapy by FLT in head and neck cancer xenograft comparison with Ki67.

      More details

    Event date: 2013

  • Effects of feeding conditions on the myocardial and hepatic accumulation of radioiodine-labeled BMIPP in mice.

    その他の会議  

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    Event date: 2014

  • Increased intratumoral FLT uptake after multi-kinase inhibitor sorafenib treatment in human renal cell carcinoma xenograft.

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    Event date: 2012

  • Changes in tumor oxygen states after sorafenib therapy evaluated by using 18F-fluoromisonidazole hypoxia imaging in a renal cell cancer xenograft.

    その他の会議  

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    Event date: 2014

  • Monitoring intratumoral proliferative and hypoxic responses to radiotherapy by FLT and FMISO in human head and neck cancer xenograft.

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    Event date: 2012

  • 動脈硬化血管とマクロファージの代謝解析:低酸素による解糖系・ペントースリン酸回路の代謝産物の増加。

    その他の会議  

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    Event date: 2014

  • FLT can early reflect response of tumor proliferation to multikinase inhibitor (sorafenib) treatment in a human renal cell carcinoma xenograft: comparison with Ki-67.

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    Event date: 2012

  • Evaluation of dynamic changes in tumor hypoxia and proliferation after radiotherapy in human head and neck cancer xenograft using dual tracers of FMISO and FLT.

    その他の会議  

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    Event date: 2014

  • 骨髄間質細胞移植は脳梗塞周囲の神経受容体機能を改善させる―&lt;sup&gt;123&lt;/sup&gt;I‐iomazenil SPECTによる検討

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    Event date: 2012

  • Mechanisms of anti-tumor effects underlying sorafenib treatment: evaluation of tumor oxygen states using 18F-FMISO in a human lung cancer xenograft.

    その他の会議  

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    Event date: 2014

  • 腎細胞癌移植マウスにおけるマルチキナーゼ阻害剤Sorafenib治療後のFLTによる治療反応評価

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    Event date: 2012

  • 肉芽腫・腫瘍の鑑別診断における18F-FMISO低酸素イメージング:小動物用PETを用いたラットモデルにおける14C-FDGとの比較。

    その他の会議  

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    Event date: 2014

  • がんの診断・治療効果評価におけるPETの応用~基礎研究を中心に~

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    Event date: 2012

  • Increased metabolite levels of glycolysis and pentose phosphate pathway in rabbit atherosclerotic arteries and hypoxic macrophage.

    その他の会議  

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    Event date: 2014

  • 腫瘍・肉芽腫における&lt;sup&gt;18&lt;/sup&gt;F‐FMISO集積の特徴:&lt;sup&gt;18&lt;/sup&gt;F‐FDG及び組織学的比較

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    Event date: 2012

  • Irbesartan reduces atherosclerosis in Watanabe Heritable Hyperlipidemic (WHHL) rabbits: Non-invasive imaging of inflammation with 18F-FDG PET

    その他の会議  

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    Event date: 2013

  • 腎細胞癌移植モデルにおける抗血管新生剤(sorafenib)の治療反応のFMISO PETによる評価

    その他の会議  

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    Event date: 2013

  • 放射線照射により生成される一酸化窒素は固形腫瘍の再酸素化に必須である.

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    Event date: 2012

  • 抗血管新生剤(sorafenib)の抗腫瘍効果の機序:肺癌細胞移植モデルにおけるFMISOによる腫瘍内酸素状態の評価

    その他の会議  

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    Event date: 2013

  • 動脈血栓能を反映する18F‐フルオロデオキシグルコースの血管集積

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    Event date: 2012

  • Prediction of early antiproliferative response to anti-VEGF monoclonal antibody molecular-targeting therapy (bevacizumab) in human tumor xenograft using FLT

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    Event date: 2009

  • 動脈硬化病変における炎症細胞への18F-FDG集積と低酸素との関連: バルーン傷害モデルでの検討

    その他の会議  

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    Event date: 2013

  • 固形腫瘍内における放射線誘導性再酸素化の動態の評価

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    Event date: 2012

  • 放射線照射により生成される一酸化窒素は固形腫瘍の再酸素化に必須である。

    その他の会議  

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    Event date: 2012

  • 動脈血栓能を反映する18F‐フルオロデオキシグルコースの血管集積

    その他の会議  

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    Event date: 2012

  • 18F-FLT can detect early antiproliferative response to anti-EGFR molecular targeting therapy (cetuximab) in human lung cancer xenograft.

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    Event date: 2009

  • 腫瘍と肉芽腫の鑑別診断におけるDynamic 18F-Fluoro-L-a-methyltyrosine (18F-FAMT)-PETの有用性

    その他の会議  

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    Event date: 2013

  • FMISO PET reflects antiangiogenic tumor response to multi-kinase inhibitor (sorafenib) in human renal cell carcinoma xenograft.

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    Event date: 2012

  • FMISO PET reflects antiangiogenic tumor response to multi-kinase inhibitor (sorafenib) in human renal cell carcinoma xenograft.

    その他の会議  

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    Event date: 2012

  • 18F-FLT but not 18F-FDG can early and dose-dependently detect antiproliferative responses of human tumor xenograft to epidermal growth factor receptor targeting with a tyrosine kinase inhibitor, gefitinib

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    Event date: 2007

  • Dose-dependent elevation of 18F-FDG concentration in the blood after ARB administration: Experiment in mice given telmisartan.

    その他の会議  

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    Event date: 2013

  • 固形腫瘍内における放射線誘導性再酸素化の動態の評価

    その他の会議  

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    Event date: 2012

  • チミジンホスホリラーゼを標的とする新規腫瘍イメージング剤(123I-IIMU)の開発:マウス組織におけるチミジンホスホリラーゼ発現と123I-IIMU集積との関係。

    その他の会議  

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    Event date: 2012

  • Usefulness of [C-11]methionine in differentiating tumor from granuloma: Comparison with [F-18]FDG

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    Event date: 2006

  • 18F-FMISOを用いた腎細胞癌移植モデルにおける抗血管新生療法(sorafenib)の早期治療反応の評価。

    その他の会議  

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    Event date: 2012

  • Suppressive effects of irbesartan on inflammation and apoptosis in atherosclerotic plaques of apoE-/- mice: Molecular imaging with 14C-FDG and 99mTc-annexin A5.

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    Event date: 2011

  • 18F-Fluorothymidine (18F-FLT) as early predictor of tumor response for anti-epidermal growth factor receptor antibody in human lung cancer xenograft.

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    Event date: 2011

  • 18F-Fluorothymidine (18F-FLT) as early predictor of tumor response for anti-epidermal growth factor receptor antibody in human lung cancer xenograft.

    その他の会議  

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    Event date: 2011

  • Dynamic MET PET analysis has an additional value for differentiating tumors from granulomas: An experimental study using small animal PET

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    Event date: 2009

  • Omeprazole modifies physiologic FDG uptake in the GUT.

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    Event date: 2004

  • 放射性ヨウ素標識BMIPPのマウス肝臓中挙動に及ぼす摂餌状態の影響:パルミチン酸との比較。

    その他の会議  

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    Event date: 2013

  • 放射線照射後に生成される一酸化窒素は固形腫瘍の再酸素化に関与する

    日本酸化ストレス学会学術集会プログラム・抄録集  

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    Event date: 2012

  • FMISO PET can early evaluate antiangiogenic response to anti-EGFR molecular-targeting therapy (cetuximab) in human lung cancer xenograft.

    その他の会議  

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    Event date: 2011

  • Monitoring Early Response to Molecular-Targeting Therapy (Iressa) in Human tumor xenograft using 18F-FLT.

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    Event date: 2006

  • Biologic correlates of intratumoral heterogeneity in FDG distribution with regional expressions of glucose transporters and hexokinase-II in experimental tumors.

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    Event date: 2003

  • FMISO PET reflects antiangiogenic tumor response after sorafenib treatment in human renal cell carcinoma xenograft.

    その他の会議  

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    Event date: 2013

  • 骨髄間質細胞移植は脳梗塞周囲の受容体機能を改善させる―&lt;sup&gt;123&lt;/sup&gt;I‐iomazenil SPECTによる検討

    再生医療  

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    Event date: 2012

  • FMISO PET can early evaluate antiangiogenic response to anti-EGFR molecular-targeting therapy (cetuximab) in human lung cancer xenograft.

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    Event date: 2011

  • 小動物用PET画像による腫瘍内18F-FDG集積の評価:オートラジオグラフィー画像との比較。

    その他の会議  

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    Event date: 2011

  • Dominant negative HIF-1a reduces FDG uptake in pancreatic cancer cells

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    Event date: 2002

  • Monitoring tumor proliferative activity after radiotherapy by FLT in head and neck cancer xenograft comparison with Ki67.

    その他の会議  

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    Event date: 2013

  • 放射性標識核酸誘導体による腫瘍の核医学診断と内用療法。

    その他の会議  

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    Event date: 2012

  • 18F-Fluorothymidine PET/CT as early predictor of tumor response for anti-epidermal growth factor receptor antibody in human lung cancer xenograft.

    その他の会議  

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    Event date: 2011

  • Effects of insulin and glucose loading on FDG uptake and GLUT expression in experimental inflammatory lesions and tumors

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    Event date: 2002

  • 18F-Fluorothymidine PET/CT as early predictor of tumor response for anti-epidermal growth factor receptor antibody in human lung cancer xenograft.

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    Event date: 2011

  • 動物用PETを用いた分子イメージング研究 ~腫瘍の診断と治療効果評価~。

    その他の会議  

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    Event date: 2010

  • Dynamics of 18F-FDG Uptake in Experimental Granuloma and Tumor: Basic Studies in Rat Models Using Small Animal PET/CT System

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    Event date: 2008

  • Effects of insulin and glucose loading on FDG uptake in experimental inflammatory lesions and malignant tumors

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    Event date: 2001

  • 125I-BMIPP肝臓への集積機序:絶食及び非絶食マウスにおける検討。

    その他の会議  

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    Event date: 2013

  • 高用量ARB投与によるFDG の組織集積の上昇:Telmisartan投与マウスでの検討。

    その他の会議  

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    Event date: 2010

  • Application of semiconductor gamma-camera for whole-body dynamic SPECT in small animal imaging.

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    Event date: 2006

  • Biologic Features of Intratumoral 18F-FMISO Distribution in a Rat Model of Glioma.

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    Event date: 2012

  • A novel radiolabeled probe for molecular imaging of thymidine phosphorylase: Suppressed accumulation into tumor cells by target gene knockdown.

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    Event date: 2010

  • 肉芽腫・腫瘍における18F-FMISO-PETの有用性:小動物用PETを用いた基礎的検討。

    その他の会議  

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    Event date: 2010

  • 18F-FLT can predict tumor proliferation response to radiotherapy in human head and neck cancer xenograft in comparison with Ki-67.

    その他の会議  

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    Event date: 2013

  • Early Evaluation of Antiangiogenic Response to Anti-EGFR Molecular Targeted therapy (cetuximab) by Using FMISO PET in Human Lung Cancer Xenograft.

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    Event date: 2011

  • チミジンホスホリラーゼを標的とする新規腫瘍イメージング剤の開発:siRNA導入による腫瘍細胞への集積低下。

    その他の会議  

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    Event date: 2010

  • Suppressive effects of irbesartan on inflammation and apoptosis in atherosclerotic plaques of apoE-/- mice: Molecular imaging with 14C-FDG and 99mTc-annexin A5.

    その他の会議  

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    Event date: 2011

  • Evaluation of intratumoral 18F-FDG distribution using small animal PET: Comparison with autoradiography.

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    Event date: 2010

  • A novel radiolabeled probe for molecular imaging of thymidine phosphorylase: Suppressed accumulation into tumor cells by target gene knockdown.

    その他の会議  

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    Event date: 2010

  • 腎細胞癌移植マウスにおけるマルチキナーゼ阻害剤Sorafenib治療後のFLTによる治療反応評価。

    その他の会議  

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    Event date: 2012

  • Evaluation of intratumoral 18F-FDG distribution using small animal PET: Comparison with autoradiography.

    その他の会議  

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    Event date: 2010

  • 11C-Methionine but not 18F-FDG and 18F-FLT can differentiate tumor from granuloma in experimental rat models.

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    Event date: 2006

  • Sequential evaluation of intratumoral proliferative activity after radiotherapy by FLT in human head and neck cancer xenograft.

    その他の会議  

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    Event date: 2013

  • PREDICTION OF EARLY ANTIPROLIFERATIVE RESPONSE TO ANTI-EGFR MOLECULA-TARGETING THERAPY (CETUXIMAB) IN HUMAN TUMOR XENOGRAFT USING 18F-FLT PET.

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    Event date: 2010

  • 分子イメージング装置を用いた研究とその成果~動物用PETを中心に~。

    その他の会議  

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    Event date: 2010

  • 特別講演1.癌の診断・治療効果評価におけるPETの応用~基礎研究を中心に~

    その他の会議  

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    Event date: 2012

  • 北海道大学における小動物インビボイメージング研究の現状。第7回小動物インビボイメージング研究会

    その他の会議  

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    Event date: 2012

  • PREDICTION OF EARLY ANTIPROLIFERATIVE RESPONSE TO ANTI-EGFR MOLECULA-TARGETING THERAPY (CETUXIMAB) IN HUMAN TUMOR XENOGRAFT USING 18F-FLT PET.

    その他の会議  

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    Event date: 2010

  • ApoE-/-マウス動脈硬化に対するテルミサルタンの治療効果: 99mTc-annexin A5による評価。

    その他の会議  

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    Event date: 2011

  • A radiolabeled uracil derivative as a novel SPECT tracer for thymidine phosphorylase (TP): cell specific uptake responses to TP expression.

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    Event date: 2010

  • A radiolabeled uracil derivative as a novel SPECT tracer for thymidine phosphorylase (TP): cell specific uptake responses to TP expression.

    その他の会議  

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    Event date: 2010

  • 腫瘍・肉芽腫における18F-FMISO集積の特徴:18F-FDF及び組織学的比較。

    その他の会議  

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    Event date: 2012

  • Biological characteristics of intratumoral 18F-FMISO distribution in a rodent model of glioma.

    その他の会議  

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    Event date: 2010

  • Evaluation of early response to epidermal growth factor receptor targeting therapy with the tyrosine kinase inhibitor, gefitinib (Iressa) in human xenograft using 18F-FLT.

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    Event date: 2006

  • Utility of 99mTc-annexin A5 for Evaluating the Therapeutic Effect of ARB on Atherosclerosis: an Experimental Study with Telmisartan Treated apoE-/- Mice.

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    Event date: 2011

  • Biological characteristics of intratumoral 18F-FMISO distribution in a rodent model of glioma.

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    Event date: 2010

  • Hypoxia imaging with 18F-fluoromisonidazole (FMISO) for differentiating tumors from granulomas: a comparison with FDG in experimental rat models using small animal PET.

    その他の会議  

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    Event date: 2010

  • Increased intratumoral FLT uptake after multi-kinase inhibitor sorafenib treatment in human renal cell carcinoma xenograft.

    その他の会議  

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    Event date: 2012

  • Early Evaluation of Antiangiogenic Response to Anti-EGFR Molecular Targeted therapy (cetuximab) by Using FMISO PET in Human Lung Cancer Xenograft.

    その他の会議  

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    Event date: 2011

  • FLT PET can early predict antiproliferative response to anti-EGFR molecular-targeting therapy (cetuximab) in human lung cancer xenograft.

    その他の会議  

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    Event date: 2010

  • Hypoxia imaging with 18F-fluoromisonidazole (FMISO) for differentiating tumors from granulomas: a comparison with FDG in experimental rat models using small animal PET.

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    Event date: 2010

  • Biologic aspects of intratumoral [18F]FMISO distribution in a rodent model of glioma.

    その他の会議  

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    Event date: 2010

  • Dynamics of 18F-FDG uptake in experimental granulomas induced with activated macrophages: Comparison with malignant tumors

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    Event date: 2008

  • Monitoring intratumoral proliferative and hypoxic responses to radiotherapy by FLT and FMISO in human head and neck cancer xenograft.

    その他の会議  

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    Event date: 2012

  • Careful assessment of FDG uptake due to elevated FDG concentration in the blood and organs by high dose ARB administration: Experiment in mice given telmisartan.

    その他の会議  

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    Event date: 2010

  • Modification of FDG uptake by steroid pretreatment: a potential means for differentiating tumor from granuloma by PET

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    Event date: 2005

  • Effects of feeding conditions on the hepatic pharmacokinetics of radioiodine-labeled BMIPP in mice: Comparison with palmitic acid.

    その他の会議  

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    Event date: 2013

  • FLT PET can early predict antiproliferative response to anti-EGFR molecular-targeting therapy (cetuximab) in human lung cancer xenograft.

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    Event date: 2010

  • 不安定プラークの検出における18F-FDGと99mTc-annexin A5の有用性:ApoE-/-マウスの動脈硬化病変への集積と病理学的検討。

    その他の会議  

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    Event date: 2010

  • Radioiodinated BMIPP as a potential probe for hepatic fatty acid metabolism: evaluation in mice at different feeding status.

    その他の会議  

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    Event date: 2013

  • FLT can early reflect response of tumor proliferation to multikinase inhibitor (sorafenib) treatment in a human renal cell carcinoma xenograft: comparison with Ki-67.

    その他の会議  

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    Event date: 2012

  • ヒト癌移植マウスにおける抗EGFR抗体(Cetuximab)による分子標的療法:18F-FLT PETを用いた早期治療効果評価。

    その他の会議  

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    Event date: 2010

  • Utility of 99mTc-annexin A5 for Evaluating the Therapeutic Effect of ARB on Atherosclerosis: an Experimental Study with Telmisartan Treated apoE-/- Mice.

    その他の会議  

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    Event date: 2011

  • Biologic aspects of intratumoral [18F]FMISO distribution in a rodent model of glioma.

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    Event date: 2010

  • チミジンホスホリラーゼを標的とする新規腫瘍イメージング剤の開発:siRNAによる標的ノックダウンと腫瘍細胞への集積。

    その他の会議  

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    Event date: 2010

  • 骨髄間質細胞移植は脳梗塞周囲の神経受容体機能を改善させる―&lt;sup&gt;123&lt;/sup&gt;I‐iomazenil SPECTによる検討

    その他の会議  

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    Event date: 2012

  • Double-tracer autoradiographic study with histochemical interpretation for evaluating feasibility of 18F-FDG/99mTc-annexin A5 on vulnerable plaque detection.

    その他の会議  

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    Event date: 2010

  • Performance evaluation of a semiconductor spect system for small animal imaging.

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    Event date: 2005

  • Biologic Features of Intratumoral 18F-FMISO Distribution in a Rat Model of Glioma.

    その他の会議  

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    Event date: 2012

  • Careful assessment of FDG uptake due to elevated FDG concentration in the blood and organs by high dose ARB administration: Experiment in mice given telmisartan.

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    Event date: 2010

  • ヒト癌細胞移植マウスにおける抗EGFR抗体(cetuximab)による分子標的療法:FLTを用いた早期治療効果評価。

    その他の会議  

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    Event date: 2010

  • 腎細胞癌移植マウスにおけるマルチキナーゼ阻害剤Sorafenib治療後のFLTによる治療反応評価

    その他の会議  

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    Event date: 2012

  • The therapeutic effect of telmisartan on atherosclerosis in apoE-/- mice: an evaluation with 99mTc-annexin A5.

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    Event date: 2011

  • Dynamic 11C-MET pet has an additional value for differentiating tumors from granulomas: an experimental study using small animal pet in comparison with 18F-FDG.

    その他の会議  

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    Event date: 2009

  • ヒト癌移植マウスにおける抗EGFR抗体(Cetuximab)による分子標的療法:18F-FMISOを用いた早期治療効果評価。

    その他の会議  

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    Event date: 2011

  • Dynamic 11C-MET pet has an additional value for differentiating tumors from granulomas: an experimental study using small animal pet in comparison with 18F-FDG.

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    Event date: 2009

  • ヒト癌移植マウスにおける抗VEGF抗体(Bevacizumab)による分子標的療法:FLTを用いた早期治療効果評価。

    その他の会議  

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    Event date: 2009

  • がんの診断・治療効果評価におけるPETの応用~基礎研究を中心に~

    その他の会議  

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    Event date: 2012

  • ヒト癌細胞移植マウスにおける抗EGFR抗体(Cetuximab)による分子標的療法:FLTを用いた早期治療効果評価。

    その他の会議  

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    Event date: 2009

  • Is MET valuable in differentiating cancer from granuloma?

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    Event date: 2004

  • 放射線治療に対する腫瘍増殖反応の18F-FLTによる評価:ヒト頭頸部癌移植モデル動物におけるKi-67との比較検討。

    その他の会議  

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    Event date: 2013

  • Evaluation of FMISO uptake in rat tumor tissue:comparison with FDG uptake.

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    Event date: 2009

  • Evaluation of FMISO uptake in rat tumor tissue:comparison with FDG uptake.

    その他の会議  

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    Event date: 2009

  • 腫瘍・肉芽腫における&lt;sup&gt;18&lt;/sup&gt;F‐FMISO集積の特徴:&lt;sup&gt;18&lt;/sup&gt;F‐FDG及び組織学的比較

    その他の会議  

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    Event date: 2012

  • The therapeutic effect of telmisartan on atherosclerosis in apoE-/- mice: an evaluation with 99mTc-annexin A5.

    その他の会議  

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    Event date: 2011

  • 18F-Fluorothymidine (FLT) as tumor response predictor for anti-epidermal growth factor receptor (EGFR) antibody in human lung cancer xenograft.

    その他の会議  

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    Event date: 2009

  • 18F-Fluorothymidine (FLT) as tumor response predictor for anti-epidermal growth factor receptor (EGFR) antibody in human lung cancer xenograft.

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    Event date: 2009

  • Dynamic MET PET analysis has an additional value for differentiating tumors from granulomas: An experimental study using small animal PET

    その他の会議  

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    Event date: 2009

  • Usefulness of 11C-methionine in evaluating cellular proliferation and differential diagnosis of tumor and granuloma

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    Event date: 2007

  • 骨髄間質細胞移植は脳梗塞後の局所糖代謝を改善する―小動物用PET/CTによる検討

    その他の会議  

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    Event date: 2012

  • Prediction of early antiproliferative response to anti-VEGF monoclonal antibody molecular-targeting therapy (bevacizumab) in human tumor xenograft using FLT

    その他の会議  

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    Event date: 2009

  • The effect of steroid on FDG uptake in experimental tumor, granulomatous and inflammatory lesions

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    Event date: 2004

  • ラット腫瘍組織におけるFMISO集積の評価:FDG集積との比較。

    その他の会議  

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    Event date: 2009

  • 18F-FLT can detect early antiproliferative response to anti-EGFR molecular targeting therapy (cetuximab) in human lung cancer xenograft.

    その他の会議  

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    Event date: 2009

  • Fluorothymidine (FLT)を用いた分子標的治療薬の治療効果予測。

    その他の会議  

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    Event date: 2009

  • シーメンス社製小動物用イメージング装置の使用経験。

    その他の会議  

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    Event date: 2009

  • Rhodococcus肉芽腫とラットglioma腫瘍ラットモデルにおけるFDG集積の比較検討。

    その他の会議  

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    Event date: 2008

  • Dynamics of 18F-FDG Uptake in Experimental Granuloma and Tumor: Basic Studies in Rat Models Using Small Animal PET/CT System

    その他の会議  

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    Event date: 2008

  • Dynamics of 18F-FDG uptake in experimental granulomas induced with activated macrophages: Comparison with malignant tumors

    その他の会議  

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    Event date: 2008

  • 肉芽腫・腫瘍モデルラットにおけるFDGのダイナミクス:小動物用PETを用いた基礎的検討。

    その他の会議  

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    Event date: 2008

  • チミジンホスホリラーゼ標的SPECT薬剤の合成。

    その他の会議  

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    Event date: 2008

  • 3H-FLTによる癌の分子標的療法の早期治療効果評価:担がんマウスにおける投与量依存性の検討。

    その他の会議  

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    Event date: 2007

  • 細胞の増殖能評価、腫瘍-肉芽腫の鑑別診断における11C-methionineと18F-FDGの比較。

    その他の会議  

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    Event date: 2007

  • 細胞の増殖能の評価及び腫瘍と肉芽腫の鑑別診断における11C-メチオニンの有用性:18F-FDGとの比較。

    その他の会議  

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    Event date: 2007

  • 18F-FLT but not 18F-FDG can early and dose-dependently detect antiproliferative responses of human tumor xenograft to epidermal growth factor receptor targeting with a tyrosine kinase inhibitor, gefitinib

    その他の会議  

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    Event date: 2007

  • Usefulness of 11C-methionine in evaluating cellular proliferation and differential diagnosis of tumor and granuloma

    その他の会議  

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    Event date: 2007

  • 11C-methionine(MET)の腫瘍・肉芽腫への集積性の違い:18F-FDG及び18F-FLTとの比較。

    その他の会議  

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    Event date: 2006

  • 半導体検出器が装備された小視野PET装置の基礎的検討。

    その他の会議  

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    Event date: 2006

  • 3H-FLTを用いた癌の分子標的療法(Iressa)の早期治療効果の評価。

    その他の会議  

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    Event date: 2006

  • Usefulness of [C-11]methionine in differentiating tumor from granuloma: Comparison with [F-18]FDG

    その他の会議  

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    Event date: 2006

  • Monitoring Early Response to Molecular-Targeting Therapy (Iressa) in Human tumor xenograft using 18F-FLT.

    その他の会議  

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    Event date: 2006

  • Application of semiconductor gamma-camera for whole-body dynamic SPECT in small animal imaging.

    その他の会議  

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    Event date: 2006

  • Evaluation of early response to epidermal growth factor receptor targeting therapy with the tyrosine kinase inhibitor, gefitinib (Iressa) in human xenograft using 18F-FLT

    その他の会議  

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    Event date: 2006

  • 11C-Methionine but not 18F-FDG and 18F-FLT can differentiate tumor from granuloma in experimental rat models.

    その他の会議  

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    Event date: 2006

  • 半導体検出器を用いた次世代PETカメラの開発-(3)空間分解能評価

    その他の会議  

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    Event date: 2006

  • 腫瘍及び炎症組織における3H-FLTの集積。

    その他の会議  

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    Event date: 2005

  • Modification of FDG uptake by steroid pretreatment: a potential means for differentiating tumor from granuloma by PET

    その他の会議  

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    Event date: 2005

  • Performance evaluation of a semiconductor spect system for small animal imaging.

    その他の会議  

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    Event date: 2005

  • Is MET valuable in differentiating cancer from granuloma?

    その他の会議  

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    Event date: 2004

  • 腫瘍と肉芽腫の鑑別診断におけるMETの有用性:FDGとの比較。

    その他の会議  

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    Event date: 2004

  • BCG肉芽腫及び悪性腫瘍への18F-FDG集積に及ぼすステロイドの影響。

    その他の会議  

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    Event date: 2004

  • 褐色脂肪のFDG集積に対する甲状腺機能の影響。

    その他の会議  

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    Event date: 2004

  • The effect of steroid on FDG uptake in experimental tumor, granulomatous and inflammatory lesions

    その他の会議  

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    Event date: 2004

  • Omeprazole modifies physiologic FDG uptake in the GUT.

    その他の会議  

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    Event date: 2004

  • 腫瘍組織におけるFDG分布:Gluts及びHexokinase‐IIの発現との比較。

    その他の会議  

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    Event date: 2003

  • 小動物SPECTにおける高エネルギー用ピンホールコリメータの試作。

    その他の会議  

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    Event date: 2003

  • Biologic correlates of intratumoral heterogeneity in FDG distribution with regional expressions of glucose transporters and hexokinase-II in experimental tumors

    その他の会議  

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    Event date: 2003

  • 実験的腫瘍および炎症組織への18F-FDG集積に及ぼすSteroidの影響。

    その他の会議  

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    Event date: 2002

  • Dominant negative HIF-1αの発現によるひと膵癌細胞のFDG集積低下。

    その他の会議  

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    Event date: 2002

  • Dominant negative HIF-1a reduces FDG uptake in pancreatic cancer cells

    その他の会議  

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    Event date: 2002

  • Effects of insulin and glucose loading on FDG uptake and GLUT expression in experimental inflammatory lesions and tumors

    その他の会議  

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    Event date: 2002

  • 実験的腫瘍及び炎症組織におけるFDG集積とGLUT発現の関係:インシュリン·グルコース負荷の影響。

    その他の会議  

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    Event date: 2001

  • Effects of insulin and glucose loading on FDG uptake in experimental inflammatory lesions and malignant tumors

    その他の会議  

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    Event date: 2001

  • 実験的腫瘍及び炎症組織へのFDG集積に及ぼすインシュリンとグルコース負荷の影響。

    その他の会議  

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    Event date: 2000

  • マンノース結合アルブミンの腫瘍集積。

    その他の会議  

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    Event date: 1998

  • 新規イメージング技術を用いたα線放出核種の組織内局所線量評価の基礎検討

    第58回アイソトープ・放射線研究発表会   2021.7  

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    Event date: 2021.7

  • 小動物SPECTにおける高エネルギー用ピンホールコリメータの試作。

    その他の会議  

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    Event date: 2003

  • 腫瘍組織におけるFDG分布:Gluts及びHexokinase‐IIの発現との比較。

    その他の会議  

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    Event date: 2003

  • Effects of insulin and glucose loading on FDG uptake and GLUT expression in experimental inflammatory lesions and tumors

    その他の会議  

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    Event date: 2002

  • 実験的腫瘍および炎症組織への18F-FDG集積に及ぼすSteroidの影響。

    その他の会議  

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    Event date: 2002

  • Dominant negative HIF-1αの発現によるひと膵癌細胞のFDG集積低下。

    その他の会議  

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    Event date: 2002

  • Dominant negative HIF-1a reduces FDG uptake in pancreatic cancer cells

    その他の会議  

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    Event date: 2002

  • Effects of insulin and glucose loading on FDG uptake in experimental inflammatory lesions and malignant tumors

    その他の会議  

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    Event date: 2001

  • 実験的腫瘍及び炎症組織におけるFDG集積とGLUT発現の関係:インシュリン·グルコース負荷の影響。

    その他の会議  

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    Event date: 2001

  • 実験的腫瘍及び炎症組織へのFDG集積に及ぼすインシュリンとグルコース負荷の影響。

    その他の会議  

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    Event date: 2000

  • マンノース結合アルブミンの腫瘍集積。

    その他の会議  

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    Event date: 1998

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Industrial property rights

  • アルファ線放出核種で標識された抗CD82抗体

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    Property type:Patent

    Application no:特願2022-108025  Date applied:2022.7

  • 放射性フッ素標識化合物

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    Property type:Patent

    Application no:特願2012-553103  Date applied:2012.9

    Announcement no:WO2013-042668  Date announced:2013.3

    Patent/Registration no:特許第5208328号  Date registered:2013.3  Date issued:2013.3

  • 画像診断剤、抗腫瘍効果予測装置、抗腫瘍剤効果予測方法及び抗腫瘍効果予測プログラム

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    Property type:Patent

    Application no:特願2014-153847  Date applied:2014.7

    Announcement no:特開2015-044803  Date announced:2015.3

  • 増殖性疾患の内用放射線治療剤

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    Property type:Patent

    Application no:特願2009-050415  Date applied:2009.3

    Announcement no:特開2010-202591  Date announced:2010.9

  • オクトレオチド類似体及びそれを用いた放射性画像診断剤

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    Property type:Patent

    Application no:特願2013-194032  Date applied:2013.9

    Announcement no:特開2015-059105  Date announced:2015.3

  • ウラシル化合物又はその塩、これらを有効成分として含有するイメージング剤、およびこれらを有効成分として含有する腫瘍診断をするためのイメージング剤

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    Property type:Patent

    Application no:特願2007-229002  Date applied:2007.9

    Announcement no:特開2009-062287  Date announced:2009.3

    Patent/Registration no:特許第5179811号  Date registered:2013.1  Date issued:2013.1

  • 放射性フッ素標識化合物

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    Property type:Patent

    Application no:JP2012073858  Date applied:2012.9

    Announcement no:WO2013-042668  Date announced:2013.3

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Awards

  • SNMMI2020 Poster Award (1st place)

    2020.7  

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    Country:United States

Research Projects

  • 211At-PSMAリガンドの唾液腺集積機序の解明と治療応用に関する研究

    2023.4 - 2026.3

    織内昇、趙 松吉

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    Authorship:Coinvestigator(s) 

  • 薬物送達システムとα線放出核種を組み合わせた革新的な白血病治療法の開発

    2023.4 - 2026.3

    趙 松吉

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    Authorship:Principal investigator 

  • がん幹細胞をターゲットとしたα線放出核種を用いた革新的な白血病治療法の開発

    2020.4 - 2023.3

    趙 松吉

  • 標的アルファ線治療におけるプレターゲティング法の最適化と複数がん種への適応

    2020.4 - 2023.3

    鷲山幸信、趙松吉

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    Authorship:Coinvestigator(s) 

  • Analyses of chromosomal abnormality in normal somatic cells induced by alpha-particle therapy

    2019.4 - 2022.3

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    Authorship:Coinvestigator(s) 

  • 個別化医療を志向したがんに選択的なチミジンホスホリラーゼイメージング技術の開発

    2019.4 - 2022.3

  • PD-ECGF targeted tumor treatment with new At-211 radiolabeled uracil derivatives

    2019.4 - 2022.3

  • Novel strategy for treatment of oral cancer based on hypoxia imaging

    2019.4 - 2022.3

  • Development of new therapeutic strategies for hypoxic tumors

    2018.4 - 2021.3

  • アルファ線放出核種内用療法による難治がん治療薬の開発

    2018.4 - 2021.3

  • チミジンホスホリラーゼ画像化によるがんの治療効果予測:前臨床動物実験による実証

    2016.4 - 2019.3

  • Prediction of response to anticancer therapy by thymidine phosphorylase imaging: pre-clinical proof of concept

    2016.4 - 2019.3

  • Development of alpha-particle therapy for pancreas cancer with stem cell-targeting 211At-labeled antibody

    2016.4 - 2019.3

  • がんの個別化治療戦略を実現する革新的PET診断技術の開発:[18F]DiFAによる低酸素イメージング

    2015.4 - 2017.3

  • Usefulness of imaging tumor-specific enzyme expression by radiopharmaceuticals with thymidine phosphorylase inhibitory potency

    2014.4 - 2018.3

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    Thymidine phosphorylase (TP) is an angiogenic growth factor; it catalyzes the reversible phosphorylation of thymidine to thymine. TP is overexpressed in highly malignant cancers. To identify the cancer malignancy or predict therapeutic effects of anticancer drugs based on the thymidine analog in relation to TP expression levels in tumors, we developed a radio-iodinated uracil derivative with TP inhibitory potency. Here, we elucidated its uptake mechanism into tumor cells and normal tissues based on the organic cation transporter. Our results could help advance reliability and applicability in cancer theranostics.

  • PD-ECDF-targeted tumor imaging: Development of production system for I-123 labeled compound

    2014.4 - 2017.3

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    The angiogenic factor PD-ECGF/ Thymidine phosphorylase (TP) is expressed at a high level in various solid tumors as compared with the normal tissue. In this study, we aimed to construct an automated manufacturing system for I-123 labeled IIMU that we have developed imaging targeting for PD-ECGF. During this research period, the solution composition of radioactive iodine as a raw material was changed. Therefore, we had to optimize the synthetic condition of I-123 labeled IIMU again. The results of study, it was possible to give I-123 labeled IIMU with the same radiochemical yield as conventional methods. The results of this research gave important knowledge for the automated manufacturing system of the I-123 labeled IIMU.

  • Prediction of efficacy of anticancer agents by in vivo imaging of thymidine phosphorylase

    2013.4 - 2016.3

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    Anticancer agents, 5-fluorouracil and its prodrugs, are activated by the action of an enzyme, thymidine phosphorylase (TP). In this study, we evaluated whether the efficacy of the anticancer agents could be predicted by the estimation of TP levels in cancer tissues by our in vivo imaging technique. In vitro studies showed that the higher efficacy of the anticancer agents could be obtained in the cancer cells with the higher level of TP and that factors rather than TP could also affect the efficacy. Therefore, our in vivo imaging technique for estimation of TP levels could be used for predicting the efficacy of the anticancer agents although attention would be required in diagnosis.

  • Molecular imaging in tumor proliferation and angiogenesis: Development of a early assessment tool for measuring the tumor response to treatment with molecular targeted drugs

    2011 - 2013

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    An early and accurate identification of the tumor response to therapy with molecular targeted drugs is indispensable for selecting optimal personalized treatment strategies. Thus, in this study we utilized molecular imaging technologies including PET and SPECT for visualizing tumor proliferation and angiogenesis/hypoxia, and demonstrated their usefulness in determining the tumor response to molecular targeted drugs at an earlier time stage using animal models. We also demonstrated the potential of our novel candidate compound for angiogenesis imaging in in vitro and in vivo studies. The present results could provide important evidence that may lead to the development of a novel diagnostic and assessment tool for measuring the tumor response to treatment with molecular targeted drugs, taking advantage of molecular imaging technologies for visualizing changes in tumor pathological states at the molecular and cellular levels.

  • Early andspecific detection of unstable atherosclerotic pl:aqTuiesssue factor imaging using pre-targeting systems

    2011 - 2012

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    We performed several experiments to establish a new nuclear medicine technique for imaging unstable atherosclerotic plaques through specific detection of tissue factor (TF). Consequently, we obtained several new findings concerning: 1) synthesis methods of 18F-laveled biotin-derivative, 2) PET imaging protocols and TF expression levels in our rabbit model, 3) accumulation of anti-rabbit TF monoclonal antibody in atherosclerotic lesions, and 4) blood clearance of anti-rabbit TF monoclonal antibody. These findings provided important information to establish a new nuclear medicine technique for TF imaging.

  • PETを用いた冠血管内皮機能評価方法の確立に関する研究 (分担者)

    2007.4 - 2009.3

  • Assessment of coronary endothelial function using positron emission tomography

    2007 - 2008

  • がんの個別化治療戦略を実現する革新的PET診断技術の開発:[18F]DiFAによる低酸素イメージング 

    2015.4 - 2017.3

    志賀 哲、趙 松吉

  • 腫瘍発現酵素標的イメージング―腫瘍の質的評価と治療における有用性の確立

    2014.4 - 2018.3

    大倉 一枝、趙 松吉

  • チミジンホスホリラーゼのイメージングによるがん治療効果予測の実証

    2013.4 - 2016.3

    秋澤 宏行、趙 松吉

  • 不安定プラークの特異的イメージング:低分子人工抗体を用いた核医学診断薬の開発

    2013.4 - 2014.3

  • 細胞増殖・血管新生分子イメージング:がん分子標的薬の早期治療効果評価法の確立

    2011.4 - 2014.3

  • 不安定プラークの早期・特異的同定:プレターゲティング法による組織因子イメージング (分担者)

    2011.4 - 2013.3

  • 分子イメージングによるがん病態の動的解析:臨床分子イメージングの実現へ向けて (分担者)

    2008.4 - 2011.3

  • PETを用いた冠血管内皮機能評価方法の確立に関する研究 (分担者)

    2007.4 - 2009.3

    森田 浩一、趙 松吉

  • ポジトロン断層撮影法(PET)による腫瘍・炎症の新しい診断・評価法の開発と応用

    2005.4 - 2007.3

  • 癌の分子標的療法:分子イメージングによる早期治療効果の評価

    2005.4 - 2007.3

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