Updated on 2023/07/12

写真a

 
SHIKAMA Yayoi
 
Organization
Fukushima Medical University Center for Medical Education and Career Development Professor
Title
Professor
Contact information
メールアドレス

Degree

  • 医学博士 ( 福島県立医科大学 )

Research Interests

  • Myelodysplastic syndromes (MDS) is a chronic hematopoietic disorder characterized by pancytopenia, abnormal morphology and functions of blood cells and aberrant expression of various genes. The aim of our research is to clarify the mechanism of development of the aberrant gene expression resulting in hematological abnormalities. Myelodysplastic Syndrome, TUNEL, Gene Amplification, Fetus, Transfusion, GPI anchoring membrane protein

Research Areas

  • Life Science / Hematology and medical oncology  / Hematology

  • Life Science / General internal medicine  / General Internal Medicine

  • Life Science / Medical biochemistry  / General Medical Chemistry

  • Life Science / Pharmacology  / General Pharmacology

Education

  • Fukushima Medical University   Graduate School, Division of Medicine

    - 1991

      More details

    Country: Japan

Research History

  • Fukushima Medical University   Professor

    2017.2 - Now

  • Center for Medical Education and Career Development, Division of Medical Education

    2015.4 - Now

  • Department of Pharmacology, Fukushima Medical University

    2000.2 - 2015.3

Papers

  • Mechanisms of Impaired Neutrophil Migration by MicroRNAs in Myelodysplastic Syndromes.

    Cao M, Shikama Y, Kimura H, Noji H, Ikeda K, Ono T, Ogawa K, Takeishi Y, Kimura J.

    Journal of Immunology   198 ( 5 )   1887 - 1899   2017.3

      More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • 好中球の遺伝子発現調節異常から探る病態~骨髄異形成症候群~(総説)

    色摩(亀岡)弥生

    福島医学雑誌   64 ( 1 )   2014.3

      More details

    Language:Japanese   Publishing type:Research paper (other academic)  

  • A new method for maturity-dependent fractionation of neutrophil progenitors applicable for the study of myelodysplastic syndromes.

    Hu H, Shikama Y, Shichishima T, Ikeda K, Akutsu K, Ono T, Kimura H, Ogawa K, Noji H, Takeishi Y, Kimura J.

    Biomark Res.   2 ( 1 )   2014.1

      More details

    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1186/2050-7771-2-2.

  • Effect of oral L-arginine administration on exhaled nitric oxide (NO) concentration in healthy volunteers.

    Ogata H1, Yatabe M, Misaka S, Shikama Y, Sato S, Munakata M, Kimura J.

    Fukushima J Med Sci.   59 ( 1 )   43 - 48   2013.3

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • Pharmacokinetic and Pharmacodynamic Interaction of Nadolol With Itraconazole, Rifampicin and Grapefruit Juice in Healthy Volunteers.

    Shingen Misaka, Nozomu Miyazaki, Midori S. Yatabe, TOmoyuki Ono, Yayoi Shikama, Tetsuhiko Fukushima, Junko Kimura.

    Journal of Clinical Pharmacology   53 ( 7 )   738 - 745   2013.7

      More details

    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1002/jcph.95

  • Impairment of FOS mRNA stabilization following translation arrest in granulocytes from myelodysplastic syndrome patients

    Xiaomin Feng, Yayoi Shikama, Tsutomu Shichishima, Hideyoshi Noji, Kazuhiko Ikeda, Kazuei Ogawa, Hideo Kimura, Yasuchika Takeishi, Junko Kimura

    PLoS One   8 ( 4 )   e61107   2013.4

      More details

    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1371/journal pone.0061107

  • New fractionation method of bone marrow-derived neutrophil progenitor cells for in vivo gene expression profile analyses].

    Yayoi Shikama

    Foloa Pharmacologica   141 ( 2 )   90 - 94   2013.2( ISSN:1347-8397

      More details

    Language:Japanese   Publishing type:Research paper (other academic)  

  • Maturity-dependent fractionation of neutrophil progenitors: A new method to examine in vivo expression profile of differentiation-regulating genes

    HU,Huiyuan*; SHIKAMA,Yayoi*; SHICHISHIMA,Tsutomu; IKEDA,Kazuhiko*; AKUTSU,Kazuko*; ONO, Tomoyuki*; KIMURA,Hideo; OGAWA,Kazuei*; NOJI,Hideyoshi*; TAKEISHI,Yasuchika*; KIMURA,Junko*

    Experimental Hematology   40 ( 8 )   675 - 681   2012.8

      More details

    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1016/j.exphem.2012.03.003

  • Impairment of FOS mRNA induction by a translation inhibitor puromycin in granulocytes from myelodysplastic syndromes

    SHIKAMA,Yayoi*; FENG,Xiaomin*; SHICHISHIMA,Tsutomu; ONO,Tomoyuki*; NOJI,Hideyoshi*; IKEDA,Kazuhiko*; OGAWA,Kazuei*; TAKEISHI,Yasuchika*; KIMURA,Junko*

    Br. J. Haematol.   154 ( 4 )   525 - 527   2011.4

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • Transcripts expressed using a bicistronic vector pIREShyg2 are sensitized to nonsense-mediated mRNA decay

    SHIKAMA,Yayoi*; HU,Huiyuan*; OHNO,Makiko*; MATSUOKA,Isao*; SHICHISHIMA,Tsutomu*; KIMURA,Junko*

    BMC Molecular Biology   11 ( 42 )   1 - 9   2010

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • Involvement of Na+/Ca2+ exchanger in migration and contraction of rat cultired tendon fibroblasts

    SAKAMOTO,Kazuho*; OWADA,Yukiko*; SHIKAMA,Yayoi*; WADA,Ikuo*; WAGURI,Satoshi*; IWAMOTO,Takahiro; KIMURA,Junko*

    Journal of Physiology   587 ( 22 )   5345 - 5359   2009

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • Functional changes induced by long-term stimulation of nicotinic acetylcholine receptors: Na+-Ca2+ exchanger expression and modulation

    KIMURA,Junko*; ONO,Tomoyuki*; SAKAMOTO,Kazuho*; ITO,Emi; WATANABE,Shinya; MAEDA,Sachiko*; SHIKAMA,Yayoi*; SASAKI,Midori Y*; MATSUOKA,Isao*

    Biol. Pharm. Bull.   32   325 - 331   2009

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • Terminally differentiated neutrophils predominantly express Survivin-2alpha, a dominant-negative isoform of Survivin.

    HU,Huiyuan*; SHIKAMA,Yayoi*; MATSUOKA,Isao*; KIMURA, Junko*

    Journal of Leukocyte Biology   83   393 - 400   2008.2

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • Accumulation of an intron-retained mRNA for guanulocyte macrophage-colony stimulating factor receptor common ß chain in neutrophils of myelodysplastic syndromes

    SHIKAMA,Yayoi*; SHICHISHIMA,Tsutomu*; MATSUOKA,Isao*; JUBINSKY,Paul T; SIEFF,Colin A; MARUYAMA,Yukio*

    Journal of Leukocyte Biology   77   811 - 819   2005

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • Inhibitory effect of thiopental on ultra-rapid delayed rectifier K+ kurrent in H9c2 cells

    SUZUKI,Hideki*; MOMOI,Nobuo*; ONO, omoyuki*; MAEDA,Sachiko*; SHIKAMA,Yayoi*; MATSUOKA,Isa*; SUZUKI,Hitoshi*; KIMURA,Junko*

    J. Pharm. Pharmacol.   99   177 - 184   2005

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • Transfusion-related acute lung injury following allogeneic bone marrow transplasntation in a patient with acute lymphoblastic leukemia.

    NOJI,Hideyoshi*; SHICISHIMA,Tsutomu*; OGAWA,Kazuei*; SHIKAMA,Yayoi*; Hitoshi Ohto*; MARUYAMA,Yukio*

    Internal Medicine   43   1068 - 1072   2004

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • Granulocyts from patients with paroxysmal nocturnal hemoglobinuria and normal individuals have the same sensitivity to spontaneous apoptosis.

    Experimental Hematology   30   187 - 194   2002

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • Treatment for the decline of ionized calcium levels during peripheral blood progenitor cell harvesting.

    KISHIMOTO,Masahiro*; OHTO,Hitoshi*; SHIKAMA,Yayoi*; KIMIJIMA,Izoh*; TAKENOSHITA,Seiichi*

    Transfusion   42   1340 - 1347   2002

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • Neutrophil-specific reduction in the expression of GM-CSF receptor subunits in myelodysplastic syndromes.

    British Journal of Haematology   111   863 - 872   2000

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • 末梢血幹細胞採取時の血中イオン化カルシウム値の動態

    岸本昌浩, 大戸 斉, 色摩弥生, 相良浩哉, 君島伊造, 阿部力哉

    日本輸血学会誌   45   256 - 261   1999

      More details

    Language:Japanese   Publishing type:Research paper (other academic)  

  • アフェレーシス末梢血幹細胞の定量:CD34陽性細胞数とCFU-GM数の相関

    岩淵伸枝, 安斎美智子, 赤間敏子, 安田広康, 色摩弥生, 大戸 斉

    医学検査   47   1686 - 1689   1998

      More details

    Language:Japanese   Publishing type:Research paper (other academic)  

  • A constitutively activated chimeric cytokine receptor confers factor-independent growth in hematopoietic cell lines.

    Blood   88 ( 2 )   455 - 464   1996

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • The (]J0946[)c component of the GM-CSF/IL3/IL5 receptor interacts with a hybrid GM-CSF/Epo receptor to influence proliferation and (]J0946[)-globin mRNA expression.

    Molecular Medicine   2 ( 6 )   766 - 773   1996

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • Human granulocyte-macrophage colony-stimulating factor receptor signal transduction requires the proximal cytoplasmic domain of the alpha and beta subunits.

    Michael Weiss, Charles Yokoyama, Yayoi Shikama, Christine Naugle, Brian Druker, Colin Sieff

    Blood   82 ( 11 )   3293 - 3306   1993.12

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • Thrombopoietic effects of interleukin-6 in long-term administration in mice.

    Toshiyuki Ishibashi, Yayoi Shikama, Hideo Kimura, Michiko Kawaguchi, Tatsumi Uchida, Tadashi Yamamoto, Akira Okano, Yukio Akiyama, Toshio Hirano, Tadamitsu, Kishimoto, and Yukio Maruyama

    Experimental Hematology   21 ( 5 )   641 - 646   1993.5

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • Transient effect of erythropoietin on thrombopoiesis in vivo in mice.

    Yayoi Shikama, Toshiyuki Ishibashi, Hideo Kimura, Michiko Kawaguchi, Taysumi Uchida, and Yukio Maruyama

    Experimental Hematology   20 ( 2 )   216 - 222   1992.2

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • Isolation of rat megakaryocytes by immunomagnetic beads.

    Yayoi Shikama

    Fukushima Journal of Medical Science   36   59 - 70   1990

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • Interleukin-1 beta (IL-1 beta) induces thrombocytosis in mice: possible implication of IL-6.

    Hideo Kimura, Toshiyuki Ishibashi, Yayoi Shikama, Akira Okano, Yukio Akiyama, Tatsumu Uchida, and Yukio Maruyama

    Blood   76 ( 12 )   2493 - 2500   1990.12

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • Effect of recombinant granulocyte-macrophage colony-stimulating factor on murine thrombocytopoiesis in vitro and in vivo.

    Toshiuiki Ishibashi, Hideo Kimura, Yayoi Shikama, Tatsumi Uchida, Shigeo Kariyone, and Yukio Maruyama.

    Blood   75 ( 7 )   1433 - 1438   1990.4

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • High incidence of 17p13 chromosomal abnormalities in malignant histiocytosis.

    Rokuo Abe, Yasushi Akaike, Akiko Yokoyama, Yayoi Shikama, Toshiyuki Ishibashi, Masayuki Mita, Hideo Kimura, Tatsumi Uchida, Shigeo Kariyone, and Haruki Wakasa

    Cancer   65 ( 12 )   2689 - 2696   1990.6

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • Interleukin-6 is a potent thrombopoietic factor in vivo in mice.

    Toshiyuki Ishibashi, Hideo Kimura, Yayoi Shikama, Tatsumi Uchida, Shigeo Kariyone, Toshio Hirano, Tadamitsu KIshimoto, Fumihiko Tadamitsu, and Yukio Akiyama

    Blood   75 ( 7 )   1433 - 1438   1989

      More details

    Language:English   Publishing type:Research paper (other academic)  

  • Comparison of Student Self-Assessment and Teacher-Assessment of Medical Interview Performance During Bedside Learning

    Zunyi Tang, Yayoi Shikama and Koji Otani

    Fukushima J Med Sci   69 ( 1 )   2023.3

      More details

    Language:Japanese  

  • Deconstructing the barriers to support Japanese students in group discussion

    Kiyotaka Yasui, Maham Stanyon, Yoko Moroi, Shuntaro Aoki, Megumi Yasuda, Koji Otani, Yayoi Shikama

    TAPS   7 ( 4 )   73 - 75   2022.10

      More details

    Language:English  

  • Breaking barriers: widening participation for cross-cultural faculty development in Japan

    Oikawa S, Stanyon M, Aoki S, Moroi Y, Yasui K, Yasuda M, Kawai T, Shikama Y, Otani K.

    Int J Med Educ   2022.6

      More details

    Language:English  

  • Optimizing simulated interviews and feedback to maximize medical students' self-efficacy in real time

    Aoki S, Shikama Y, Yasui K, Moroi Y, Sakamoto N, Suenaga H, Tang Z, Yasuda M, Chiba Y, Stanyon M, Otani K

    BMC Med Educ   22 ( 1 )   438   2022.6

      More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1186/s12909-022-03512-6

  • 臨床実習における学生の目標到達度新システム:利用状況とユーザー教員から見た導入の効果

    唐尊一、坂本信雄、色摩弥生、大谷晃司

    福島医学雑誌   77 ( 1 )   2022.4

      More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • The use of text mining to detect key shifts in Japanese first-year medical student professional identity formation through early exposure to non-healthcare hospital staff

    Shikama Yayoi, Chiba Yasuko, Yasuda Megumi, Stanyon Maham, Otani Koji

    BMC Medical Education   21 ( 1 )   389   2021.7

      More details

    Language:English   Publishing type:Research paper (international conference proceedings)  

    DOI : doi: 10.1186/s12909-021-02818-1

  • 動機づけ面接や非言語的コミュニケーションに基づく医学生へのコミュニケーション教育の試み

    青木俊太郎、竹林由武、色摩弥生、安井清孝、大谷晃司

    医学教育   52 ( 4 )   295 - 304   2021.4

      More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Impact of Green Tea Catechin Ingestion on the Pharmacokinetics of Lisinopril in Healthy Volunteers

    ShiMisaka S, Ono Y, Uchida A, Ono T, Abe O, OgaH, Sato H, Suzuki M, Onoue S, Shikama Y, Shimomura K1

    Clin Transl Sci .   14 ( 2 )   476 - 480   2021.3

      More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1111/cts.12905.

  • When I say … cultural competence.

    Stanyon Maham, Shikama Yayoi, Otani Koji

    Medical Education   2020.12

      More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : doi: 10.1111/medu.14439

  • Opening of a new skills laboratory to promote outcome-based education in Fukushima Medical University

    Moroi Yoko, Shikama Yayoi, Otani Koji

    70 ( 3 )   195 - 201   2020.12

      More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Effects of single green tea ingestion on pharmacokinetics of nadolol in healthy volunteers

    Misaka S, Abe O, Ono T, Ono Y, Ogata H, Miura I, Shikama Y, Fromm MF, Yabe H, Shimomura K.

    Br J Clin Pharmacol   86 ( 11 )   2314 - 2318   2020.11

      More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1111/bcp.14315.

  • Impact of Green Tea Catechin Ingestion on the Pharmacokinetics of Lisinopril in Healthy Volunteers

    Misaka Shingen, Ono Yuko, Uchida Atsushi, Ono Tomoyuki, Abe Osamu,

    Clinical and Translational Science   2020.10

      More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Work-life conflict, gender-based discrimination, and their associations among professionals in a medical university and affiliated hospitals in Japan: A cross-sectional study

    Yuko Ono Aya Goto, Yuko Maejima, Ikuko Maruyama, Tomoko Suzuki, Yayoi Shikama, Hiromi Yoshida-Komiya

    Fukushima J Med Sci .   66 ( 1 )   25 - 36   2020.4

      More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.5387/fms.2020-03

  • 福島県立医科大学における臨床実習改革に向けた多面的アプローチ

    坂本 信雄,唐 尊一,木村 隆,濱口 杉大,橋本 優子,色摩(亀岡) 弥生,大谷 晃司

    福島医学雑誌   70 ( 1 )   41 - 61   2020.4

      More details

    Language:Japanese  

  • Glucocorticoids attenuate the sensitivity of glucocorticoid-resistant lymphoid cells to doxorubicin via reduction in OCTN2

    Mitsuko Akaihata Yayoi Shikama, Yoshiyuki Matsumoto, Tomoyuki Ono, Junko KimuraMitsuaki Hosoya

    Mol Cell Biochem   459 ( 1-2 )   49 - 59   2019.9

      More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1007/s11010-019-03549-0

  • Introduction of TBL to clinical reasoning classes for upper grade medical school students: Significance of active learning

    Shikama Yayoi

    Fukushima Medical Journal   69 ( 1 )   59 - 66   2019.4

      More details

    Language:Japanese   Publishing type:Research paper (bulletin of university, research institution)  

  • Report on Special Classes to Prevent Unprofessional Behavior of Medical Students: Sexual Violence and Drinking Habits

    Shikama Yayoi, Osakabe Yusuke, Otani Koji

    Fukushima Medical Journal   69 ( 1 )   19 - 30   2019.4

      More details

    Language:Japanese   Publishing type:Research paper (bulletin of university, research institution)  

  • 福島県立医科大学の卒業要件OSCE実施報告 ~福島医大スタイル確立までの2016年度・2017年度advanced OSCE~

    色摩(亀岡) 弥生, 安井 清孝, 坂本 信雄, 土屋垣内 晶, 諸井 陽子, 刑部 有祐, 中島 大, 安田 恵, 千葉 靖子, 大谷 晃司

    福島医学雑誌   68 ( 2 )   113 - 120   2018.8

      More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Role of (-)-epigallocatechin gallate in the pharmacokinetic interaction between nadolol and green tea in healthy volunteers.

    Abe Osamu, Ono Tomoyuki, Sato Hideyuki, Müller Fabian, Ogata Hiroshi, Miura Itaru, Shikama Yauoi, Yabe Hirooki, Onoue Satomi, Fromm Matin F, Kimura Junko, Misaka Shingen

    Eur J Clin Pharmacol   74 ( 6 )   775 - 783   2018.6

      More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Lack of pharmacokinetic interaction between fluvastatin and green tea in healthy volunteers.

    Misaka Shingen, Abe Osamu, Sato Hideyuki, Ono Tomoyuki, Shikama Yayoi, Onoue Ssatomi, Yabe Hirooki, Kimura Junko.

    Eur J Clin Pharmacol   74 ( 5 )   601 - 609   2018.5

      More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • 福島県立医科大学医学部における臨床実習の課題克服に向けて一提案 ~医学部5・6年生が指導した1年生の臨床実習についての検討~

    坂本信雄, 小林淳, 杉本浩一, 色摩(k前岡)弥生, 竹石恭知, 大t内晃司

    福島医学雑誌   68 ( 1 )   47 - 55   2018.4

      More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • 福島県立医科大学の臨床実習改革元年(2016年)の現状報告 ~教員と学生のアンケートによる臨床実習の課題抽出~

    色摩(亀岡)弥生, 安井清孝, 刑部 有祐, 土屋垣内 晶, 中島 大, 安田 恵, 諸井 陽子, 坂本 信雄, 大谷 晃司

    福島医学雑誌   68 ( 1 )   31 - 45   2018.4

      More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • シームレスな地域連携型医学教育について

    亀岡(色摩)弥生

    光が丘   ( 47 )   71 - 72   2018.2

      More details

    Language:Japanese   Publishing type:Research paper (other academic)  

  • 医学教育変革時代の研究者育成の危機

    色摩弥生

    日本薬理学雑誌   150 ( 6 )   2017.12

      More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasms

    Koki Ueda1, Kazuhiko Ikeda, Takayuki Ikezoe, Kayo Harada-Shirado, Kazuei Ogawa, Yuko Hashimoto, Takahiro Sano, Hiroshi Ohkawara, Satoshi Kimura, Akiko Shichishima-Nakamura, Yuichi Nakamura, Yayoi Shikama, Tsutomu Mori, Philip J Mason, Monica Bessler, Soji Morishita, Norio Komatsu, Kotaro Shide, Kazuya Shimoda, Shuhei Koide, Kazumasa Aoyama, Motohiko Oshima, Atsushi Iwama, Yasuchika Takeishi

    blood advances   1 ( 15 )   1001 - 1015   2017.6

      More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Comprehensive technical and patient-care optimization in the management of pediatric apheresis for peripheral blood stem cell harvesting.

    Ohara Y, Ohto H, Tasaki T, Sano H, Mochizuki K, Akaihata M, Kobayashi S, Waragai T, Ito M, Hosoya M, Nollet KE, Ikeda K, Ogawa C, Kanno T, Shikama Y, Kikuta A.

    Transfus Apher Sci.   33 ( 3 )   338 - 343   2016.12

      More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : doi: 10.1016/j.transci.2016.09.014

  • Reduction of c-Fos via Overexpression of miR-34a Results in Enhancement of TNF- Production by LPS in Neutrophils from Myelodysplastic Syndrome Patients.

    Shikama Y, Cao M, Ono T, Feng X, Noji H, Kimura H, Ogawa K, Suzuki Y, Ikeda K, Takeishi Y, Kimura J.

    PLoS One   2016 Aug 11;11(8):e0158527   2016.8

      More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : doi: 10.1371/journal.pone.0158527

▼display all

Books

  • Clinical Pharmacotherapy

    2000.4 

     More details

    Responsible for pages:546-549   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:七島勉、色摩弥生   Publication place:東京都千代田区  

  • 臨床医 特集 血小板の臨床

    (血小板輸血の問題点)

    中外医学社  1999.1 

     More details

    Responsible for pages:50-52   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:色摩弥生、大戸斉   Publication place:東京都千代田区  

Presentations

  • Involvement of microRNAs and an RNA-binding protein in impaired stabilization of FOS mRNA under translation arrest in myelodysplastic syndrome-derived neutrophils.

      More details

    Event date: 2014.3

  • 分化に伴う遺伝子発現解析のための好中球前駆細胞の分化段階別分画採取法の確立と応用

    研究連携セミナーポスター発表会  

      More details

    Event date: 2014.2

  • Impaired stabilization of FOS mRNA in myelodysplastic syndrome-derived neutrophils.

      More details

    Event date: 2013.10

  • 骨髄異形成症候群患者好中球におけるFOS mRNA安定化不全へのmiRNAの関与

    第64回日本薬理学会北部会  

      More details

    Event date: 2013.9

  • ニコチンによる神経のNa+/Ca2+交換輸送体の蛋白質発現量増加の機序

    喫煙科学財団平成24年度助成研究発表会  

      More details

    Event date: 2013.7

  • Impairment of FOS mRNA stabilization following translation arrest in granulocytes from myelodysplastic syndrome pations

      More details

    Event date: 2013.3

  • Impairment of HuR-Mediated FOS mRNA Stabilization in Granulocytes from Myelodysplastic Syndrome Patients.

    The 55th American Society of Hematology Annual Meeting  

      More details

    Event date: 2012.12

  • Impaired FOS mRNA stabilization via AU-rich element-binding protein HuR in granulocytes from myelodysplastic syndrome patients

      More details

    Event date: 2012.10

  • Mechanism of impaired FOS mRNA induction by emetine in granulocytes from myelodysplastic syndrome patients

      More details

    Event date: 2012.10

  • Impairment of emetine-induced FOS mRNA stabilization in granulocytes from myelodysplastic syndrome patients

      More details

    Event date: 2012.9

  • FOS induction by emetine via p38MAPK and RNA-binding protein HuR in human granulocytes

    The 85th Annual Meeting of The Japanese Pharmacological Society  

      More details

    Event date: 2012.3

  • Increase in exhaled NO by oral arginine in subjects with a history of allergy

    The 85th Annual Meeting of The Japanese Pharmacological Society  

      More details

    Event date: 2012.3

  • p38 MAPK-mediated transcription and HuR-associated mRNA stabilization in FOS induction by emetine in human granulocytes

      More details

    Event date: 2011.12

  • Mechanism ofimmediate early gene FOS induction by emetin in human granulocytes

      More details

    Event date: 2011.9

  • Involvement of RNA-binding protein HuR in c-Fos mRNA stabilization by emetin in human granulocytes

    The 84th annual meeting of the Japanese Pharmacology Society  

      More details

    Event date: 2011.3

  • Dopamin potentiates Na+/Ca2+ exchanger expression in NGF-differentiatiated PC12 cells

      More details

    Event date: 2011.3

  • 長期ニコチン受容体刺激により誘発されるNa+/Ca2+交換輸送体の変化

    「長期ニコチン受容体刺激により誘発される生体機能変化」発表会  

      More details

    Event date: 2011.2

  • Impaired c-fos induction by emetin in granulocytes from myelodysplastic syndrome patients

    The 72nd Annual Meeting of the Japanese Society of Hematology  

      More details

    Event date: 2010.9

  • 長期ニコチン受容体刺激により誘発されるNa+/Ca2+輸送体の変化

    第25回平成21年度助成研究発表会  

      More details

    Event date: 2010.7

  • 発現ベクターpIREShyg2依存的に誘導されるnonsense-mediated mRNA decayの遺伝子発現に 対する影響

    日本生化学会東北支部 第76回例会・シンポジウム  

      More details

    Event date: 2010.5

  • Differentiation-related gene expression in neutrophils from myelodysplastic syndrome patients

    The 83rd Annual Meeting of The Japanese Pharmacology Society  

      More details

    Event date: 2010.3

  • Impaired c-Fos induction by emetin in neutrophils from myelodysplastic syndrome patients

    The 83rd Annual Meeting of The Japanese Pharmacology Society  

      More details

    Event date: 2010.3

  • Diversity in the efficiency of NMD among NMD-sensitive mRNA

    The 82nd Annual Meeting of The Jaoanese Pharmacology Socisty  

      More details

    Event date: 2009.3

  • Effects of nonsense-mediated mRNA decay on gene expression in myelodysplastic syndromes

      More details

    Event date: 2009.10

  • 骨髄異形成症候群患者の好中球分化に伴う遺伝子発現調節異常の解析

    第70回日本血液学会総会  

      More details

    Event date: 2008.10

  • ナンセンスコドン複数保有フレームシフト産物に対するnonsense-mediated mRNA decay活性の検討

    第81回日本薬理学会年会  

      More details

    Event date: 2008.3

  • ナンセンスコドンを複数保有するフレームシフト産物に対するnonsense-mediated mRNA decay活性の検討

    第30回日本分子生物学会年会代80回日本生化学会年会合同大会  

      More details

    Event date: 2007.12

  • 好中球に発現するサバイビンアイソフォームはGM-CSF/G-CSFによるアポトーシス抑制に関与しない

    第69回日本血液学会第49回日本臨床血液学合同総会  

      More details

    Event date: 2007.10

  • mRNAサーベイランス機構によるナンセンスコドン複数保有スプライスバリアント分解活性の解析

    第69回日本血液学会第49回日本臨床血液学会合同総会  

      More details

    Event date: 2007.10

  • Nonsense-mediated mRNA decayによるナンセンスコドン複数保有のスプライスバリアント分解活性の解析

    第58回日本薬理学会北部会  

      More details

    Event date: 2007.9

  • 長期ニコチン受容体刺激により誘発されるNa+/Ca2+交換輸送体の変化

    第22回平成18年度喫煙科学研究財団助成研究発表会  

      More details

    Event date: 2007.7

  • No contribution of survivin to GM-CSF/G-CSF-induced anti-apoptotic effects on terminally differentiated neutrophils

      More details

    Event date: 2007

  • Survivin is not involved in GM-CSF/G-CSF-induced survival of neutrophilic granulocyte

      More details

    Event date: 2007

  • GM-CSF受容体ナンセンスコドン保有スプライスバリアントに対するmRNAサーベイラインス機構の作用

    第68回日本血液学会総会  

      More details

    Event date: 2006

  • GM-CSFによるsurvivin誘導とその好中球アポトーシス抑制における役割の検討

    第68回日本血液学会総会  

      More details

    Event date: 2006

  • Effects of a nonsense-medaited mRNA decay inhibitor on a splice variant with PTCs

    The 79th Annual Meeting of The Japanese Pharmacological Society  

      More details

    Event date: 2006

  • Lineage-specific surviving induction by GM-CSF

    The 79th Annual Meeting of The Japanese Pharmacological Society  

      More details

    Event date: 2006

  • 骨髄異形成症候群例のGM-CSF受容体beta鎖splice variant増加に対するnonsense-mediated mRNA decayの役割

    第67回日本血液学会・第47回日本臨床血液学会・合同総会  

      More details

    Event date: 2005

  • Effects of alternative splicing and nonsense-mediated mRNA decay on the expression of a variant of GM-CSF receptor beta chain in myelodysplastic syndromes

    The 8th International Symposium on Myelodysplastic Syndromes  

      More details

    Event date: 2005

  • A social media-based, text-adventure medical escape room for Japanese medical students during COVID-19

    AMEE2022   2022.8  

      More details

    Event date: 2022.8

  • Breaking language and cultural barriers for participation –cross-cultural Faculty Development for the recognition of unprofessional behavior in Japan-

    2022.8  

      More details

    Event date: 2022.8

  • 臨床現場の医師は実技試験問題作成に際してどのような点に難しさを感じているのか

    第54回日本医学教育学会大会   2022.8  

      More details

    Event date: 2022.8

  • 授業時間内に学習者の思考を把握し対応したオンライン”基礎臨床統合―反転授業”

    第54回日本医学教育学会大会   2022.8  

      More details

    Event date: 2022.8

  • コミュニケーション講義が医学生のコミュニケーションを追い込なう自信に与える影響の性差

    第54回日本医学教育学会大会   2022.8  

      More details

    Event date: 2022.8

  • ドキュメンタリー動画を取り入れたコロナ禍での地域体験実習代替授業

    第54回日本医学教育学会大会   2022.8  

      More details

    Event date: 2022.8

  • The culturally constructed face of professionalism: International Japan-UK Q-method study update

    2022.8  

      More details

    Event date: 2022.8

  • Nurturing professional identity formation through early clinical exposure to non-healthcare professionals

    The virtual conference AMEE 2021  

      More details

    Event date: 2021.8

  • Concept maps as an adjunct in the assessment of medical interview skills in English for Japanese students

    The virtual conference AMEE 2021  

      More details

    Event date: 2021.8

  • Resident self-assessment of clinical competence at the start of training in Fukushima

      More details

    Event date: 2021.7 - 2021.8

  • Deconstructing the barriers to support Japanese medical students in group discussion

      More details

    Event date: 2021.7

  • Cross-cultural constructions of unprofessional behaviour: a Qmethod pilot study

    第53回日本医学教育学会大会  

      More details

    Event date: 2021.7

  • Implement of online "early clinical exposure"

      More details

    Event date: 2021.7

  • Astudy of professionalism cultivated through online community experience ttraining

      More details

    Event date: 2021.7

  • Transformation of concept maps as a strategy for remote assessment in Japanese medical education

    第52回日本医学教育学会大会  

      More details

    Event date: 2020.7

  • 地域体験実習を通して醸成されるプロフェッショナリズムに関する検討

    第52回日本医学教育学会大会  

      More details

    Event date: 2020.7

  • Concept mapping as a novel adjunct to the assessment of Japanese medical students in English

    第52回日本医学教育学会大会  

      More details

    Event date: 2020.7

  • Moodleを活用した臨床実習の双方向性評価システムの構築

    第52回日本医学教育学会大会  

      More details

    Event date: 2020.7

  • コミュニケーション講義が医学生のコミュニケーションをお行う自信に与える影響

    第52回日本医学教育学会大会  

      More details

    Event date: 2020.7

  • タトゥシールを用いた身体診察模擬患者へのムラージュ

    第52回日本医学教育学会大会  

      More details

    Event date: 2020.7

  • 早期臨床体験実習のバックヤード見学が学生に与える影響

    第51回日本医学教育学会大会  

      More details

    Event date: 2019.7

  • コミュニケーション講義が医学生のコミュニケーションを行う自信に与える影響

    第51回日本医学教育学会大会  

      More details

    Event date: 2019.7

  • 臨床実習へのモデル・コア・カリキュラムの活用と自己評価表の導入~国際認証受審に向けた本学の取り組み~

    第51回日本医学教育学会大会  

      More details

    Event date: 2019.7

  • 鑑別疾患想起能力に対する症候論講義とTBL授業の比較

    第51回日本医学教育学会大会  

      More details

    Event date: 2019.7

  • 医学部におけるチーム基盤型学習(TBL)の導入に関する全国調査

    第51回日本医学教育学会大会  

      More details

    Event date: 2019.7

  • 「大学教員にとっての研究 ~医学研究と教育研究の経験から~」

    福島医学会第476回学術研究集会  

      More details

    Event date: 2019.5

  • 臨床実習72週化に伴うスキルラボ利用の変化

    第12回東北シミュレーション医学医療教育研究会大会  

      More details

    Event date: 2018.12

  • 地域実習における視聴覚教材の検討

    第50回医学教育学会  

      More details

    Event date: 2018.8

  • 医学部1年生地域実習におけるディスカッションベースド発表会

    第49回日本医学教育学会大会  

      More details

    Event date: 2017.8

  • Effects of Prednisolone on expression of drug uptake transporters in lymphoid tumor cells

    第90 回日本薬理学会年会  

      More details

    Event date: 2017.3

  • Mechanisms of impaired neutrophil migration by microRNAs in myelodysplastic syndromes

    第90回日本薬理学会年会  

      More details

    Event date: 2017.3

  • Impaired neutrophil migration resulting from miR-34a and miR-155 overexpressed in neutrophils from myelodysplastic syndrome patients

    The 57th American Society of Hematology Annual Meeting  

      More details

    Event date: 2015.12

  • Excessive TNF-alpha production resulting from reduction of c-fos via aberrant expression of miR-34a in neutrophils from myelodysplastic syndrome patients

    The 57th American Society of Hematology Annual Meeting  

      More details

    Event date: 2015.12

  • Cao Maiwan, Shikama Yayoi, Kimura Junko

      More details

    Event date: 2015.10

  • Excessive TNFalpha production via reduced expression of c-Fos in neutrophils from myelodysplastic syndrome patients

      More details

    Event date: 2015.10

  • miR-34a targets Cdc42 activator DOCK8 and miR-155 targets Cdc42 activator FGD4 or Rac1 to impair neutrophil migration in MDS

      More details

    Event date: 2015.9

  • 酸化ストレス下のTNF-α産生に対するc-fosの抑制作用

    第66回日本薬理学会北部会  

      More details

    Event date: 2015.9

  • Effects of miR-34a and miR-155 oversxpression on neutrophil functions.

    The 65th Hokubu Meeting of Japanese Society of Pharmacology  

      More details

    Event date: 2014.9

  • Approach to pathogenesis of myelodysplastic syndromes via aberrant gene expression in neutrophils.

    Lab seminer in North African Research center,Tsukuba University  

      More details

    Event date: 2014.7

▼display all

Research Projects

  • Identification of therapeutic target molecules for ineffective hematopoiesis in myelodyspplastic syndromes

    2014.4 - 2017.3

      More details

    We recently found that c-Fos induction in response to translation-inhibiting stress was attenuated in neutrophils under translation arrest caused from myelodysplastic syndrome patients. The current study aims to clarify how c-Fos prevents NF-kB over-activation under various stress, such as oxidative and ER stress, and irradiation.

  • Clarification of therapeutic targets for functional defects of blood cells in myelodysplatic syndromes

    2011.4 - 2013.3

      More details

    We found that c-Fos induction in response to translation-inhibiting stimuli was attenuated in neutrophils from myelodysplastic syndrome patients. The aberrant c-Fos induction resulted from insufficient stabilization of c-Fos mRNA, which was caused by decreased HuR, an mRNA-binding protein, and overexpressions of two microRNAs targeting c-Fos.

  • sgRNAによるPNHクローンの拡大抑制に関する基礎的検討

    2010.4 - 2013.3

    七島 勉、色摩弥生

  • Relevance of abnormal induction of c-fos to scenescence in myelodysplastic syndromes.

    2008.9

  • Elucidation of the mechanism to develope aberrant gene expression during myeloid differentiation in myelodysplastic syndromes.

    2007.4

  • Analyses of the reduction in GM-CSF receptor in neutrophils isolated from patients with myelodysplastic syndromes

    2006.4

▼display all