Updated on 2023/12/13

写真a

 
INOUE Naokazu
 
Organization
Research Facility Attached to the School of Medicine Department of Cell Science Associate Professor
Title
Associate Professor
Contact information
メールアドレス

Degree

  • 博士 (薬学) ( 2002.3   大阪大学 )

Research Interests

  • 受精・膜融合・精子・卵子

Research Areas

  • Life Science / Developmental biology  / Developmental Biology

  • Life Science / Cell biology  / Cell Biology

  • Life Science / Molecular biology  / Molecular Biology

  • Life Science / Structural biochemistry  / Structural Biochemistry

  • Life Science / Laboratory animal science  / Laboratory Animal Studies

Education

  • Osaka University   Graduate School, Division of Pharmaceutical Sciences

    - 2002.3

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    Country: Japan

  • Toho University   Graduate School, Division of Natural Science

    - 1999.3

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    Country: Japan

  • Toho University   Faculty of Science

    - 1997.3

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    Country: Japan

Research History

  • Fukushima Medical University   Professor

    2023.11 - Now

  • Fukushima Medical University   Associate Professor

    2013.5 - 2023.10

  • Osaka University   Assistant Professor

    2007.4 - 2013.4

  • Osaka University   Instructor

    2004.5 - 2007.3

  • 独立行政法人日本学術振興会・特別研究員 (PD)   特別研究員

    2002.4 - 2004.4

Professional Memberships

Committee Memberships

  •   組換えDNA実験安全委員会委員  

    2023.4 - Now   

  •   研究用微生物安全管理委員会委員  

    2023.4 - Now   

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    Committee type:Other

  •   安全主任者  

    2015.4 - 2023.3   

  •   動物実験委員会委員 (副委員長)  

    2014.1 - Now   

Papers

  • Involvement of cellular protrusions in gamete interactions

    Yuhkoh Satouh, Naokazu Inoue

    Seminars in Cell & Developmental Biology   129   93 - 102   2022.9

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    Language:English  

  • Deletion of the initial methionine codon of the Tmem95 gene causes subfertility, but not complete infertility, in male mice

    Naokazu Inoue, Ikuo Wada

    Biology of Reproduction   106 ( 3 )   378 - 381   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1093/biolre/ioab246

    PubMed

  • Gamete Fusion Assay in Mice

    Naokazu Inoue

    Bio-protocol   11 ( 22 )   e4233.   2021.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.21769/BioProtoc.4233

  • IZUMO family member 3, IZUMO3, is involved in male fertility through the acrosome formation.

    Naokazu Inoue1, Yuhkoh Satouh, Ikuo Wada

    Molecular Reproduction and Development   88 ( 7 )   479 - 481   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/mrd.23520

    PubMed

  • 進化の過程で10億年間保存されてきた配偶子融合因子

    井上直和

    実験医学   39 ( 13 )   2126 - 2129   2021.7( ISSN:978-4-7581-2546-8

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    Language:Japanese   Publishing type:Research paper (other academic)  

  • Evolutionarily conserved sperm factors, DCST1 and DCST2, are required for gamete fusion

    Naokazu Inoue, Yoshihisa Hagihara, Ikuo Wada

    eLife   10 ( e66313 )   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.7554/eLife.66313.

    PubMed

  • Tet1 is not required for myeloid leukemogenesis by MLL-ENL in novel mouse models

    Ryoichi Ono, Masahiro Masuya, Naokazu Inoue, Makoto Shinmei, Satomi Ishii, Yuri Maegawa , Bishnu Devi Maharjan, Naoyuki Katayama, Tetsuya Nosaka

    PLoS One   16 ( 3 )   e0248425.   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1371/journal.pone.0248425. eCollection 2021.

    PubMed

  • Unveiling a novel function of CD9 in surface compartmentalization of oocytes

    Naokazu Inoue, Takako Saito, Ikuo Wada

    Development   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1242/dev.189985

    PubMed

  • Sperm IZUMO1-Dependent Gamete Fusion Influences Male Fertility in Mice

    Takako Saito, Ikuo Wada, Naokazu Inoue

    Int J Mol Sci   20 ( 19 )   E4809   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.3390/ijms20194809.

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  • Alternative splicing of the Izumo1 gene ensures triggering gamete fusion in mice.

    Saito T, Wada I, Inoue N

    Scientific reports   9 ( 1 )   3151   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1038/s41598-019-40130-7

    PubMed

  • Monitoring dimeric status of IZUMO1 during the acrosome reaction in living spermatozoon.

    Naokazu Inoue, Ikuo Wada

    Cell Cycle   2018.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1080/15384101.2018.1489181

    PubMed

  • Loss of VAMP5 in mice results in duplication of the ureter and insufficient expansion of the lung.

    Ikezawa M, Tajika Y, Ueno H, Murakami T, Inoue N, Yorifuji H

    Developmental Dynamics   247 ( 5 )   754 - 762   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/dvdy.24618

    PubMed

  • Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition.

    Ishikawa T, Kitaura Y, Kadota Y, Morishita Y, Ota M, Yamanaka F, Xu M, Ikawa M, Inoue N, Kawano F, Nakai N, Murakami T, Miura S, Hatazawa Y, Kamei Y, Shimomura Y

    Scientific reports   7   39825   2017.1( ISSN:2045-2322

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1038/srep39825.

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  • Novel insights into the molecular mechanism of sperm-egg fusion via IZUMO1.

    Naokazu Inoue

    Journal of Plant Research   2016.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1007/s10265-016-0895-z.

    PubMed

  • Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization.

    Ohto U, Ishida H, Krayukhina E, Uchiyama S, Inoue N, Shimizu T.

    Nature   2016.6

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1038/nature18596

  • 受精の膜融合活性化メカニズムの解明

    井上 直和

    上原記念生命科学財団研究報告集   29   1 - 7   2015.12

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm-egg fusion in mice.

    Inoue N, Hagihara Y, Wright D, Suzuki T, Wada I

    Nat Commun   6   8858   2015.11

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1038/ncomms9858

  • Isolation and characterization of antigen-specific alpaca (Lama pacos) VHH antibodies by biopanning followed by high-throughput sequencing.

    Miyazaki H, Kiyose N, Akazawa Y, Takashima M, Hagihara Y, Inoue N, MAtsuda T, Ogawa R, Inoue S, Ito Y

    J Biochem   158 ( 3 )   205 - 215   2015.9

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    Language:English   Publishing type:Research paper (other academic)  

  • ハイスループットシークエンシングを併用したバイオパンニングによる抗原特異的アルパカVHH抗体の単離と性状解析(Isolation and characterization of antigen-specific alpaca(Lama pacos) VHH antibodies by biopanning followed by high-throughput sequencing)

    Miyazaki Nobuo, Kiyose Norihiko, Akazawa Yoko, Takashima Mizuki, Hagihara Yosihisa, Inoue Naokazu, Matsuda Tomonari, Ogawa Ryu, Inoue Seiya, Ito Yuji

    The Journal of Biochemistry   158 ( 3 )   205 - 215   2015.9( ISSN:0021-924X

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Genetic dissection of pheromone processing reveals main olfactory system-mediated social behaviors in mice

    Matsuo, T., Hattori, T., Asaba, A., Inoue, N., Kanomata, N., Kikusui, T., Kobayakawa, R., Kobayakawa, K.

    Proc Natl Acad Sci U S A   112 ( 3 )   311 - 320   2015.1

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1073/pnas.1416723112

  • 哺乳類の受精の膜融合メカニズム

    井上 直和

    福島医学雑誌   64 ( 3 )   119 - 125   2014.9( ISSN:0016-2582

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    Language:English   Publishing type:Research paper (scientific journal)  

  • 精子と卵子の膜融合

    井上直和、宮戸健二

    細胞工学   33 ( 4 )   386 - 392   2014.3

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    Language:Japanese   Publishing type:Research paper (other academic)  

  • 精子と卵子の膜融合

    井上直和、宮戸健二

    細胞工学   33 ( 4 )   386 - 392   2014.3

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    Language:English   Publishing type:Research paper (scientific journal)  

  • 【受精メカニズム新論争〜ドグマの再構築〜】 精子と卵子の膜融合

    井上 直和, 宮戸 健二

    細胞工学   33 ( 4 )   386 - 392   2014.3( ISSN:0287-3796

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Molecular dissection of IZUMO1, a sperm protein essential for sperm-egg fusion

    Inoue N., Hamada D., Kamikubo H., Hirata K., Kataoka M., Yamamoto M., Ikawa M., Okabe M., Hagihara Y.

    Development (Cambridge)   140 ( 15 )   3221 - 3229   2013.8( ISSN:09501991

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1242/dev.094854

  • Production of mouse pups from germline transmission-failed knockout chimeras

    Yoshitaka Fujihara, Kazuhiro Kaseda, Naokazu Inoue, Masahito Ikawa, Masaru Okabe

    Transgenic Res   22 ( 1 )   195 - 200   2013

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    Language:English   Publishing type:Research paper (other academic)  

  • Genetic basis of cell-cell fusion mechanisms

    Pablo S. Aguilar*, Mary K. Baylies*, Andre Fleissner*, Laura Helming*, Naokazu Inoue*, Benjamin Podbilewicz, Hongmei Wang*, Melissa Wong* *These authors were equally contributed

    Trends Genet   29 ( 7 )   427 - 437   2013

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    Language:English   Publishing type:Research paper (other academic)  

  • Functional and structural study of mouse sperm protein, IZUMO1, by using molecular dissection

    Naokazu Inoue, Daizo Hamada, Hironari Kamikubo, Kunio Hirata, Mikio Kataoka, Masaki Yamamoto, Masahito Ikawa, Masaru Okabe and Yoshihisa Hagihara

    Development   140 ( 15 )   3221 - 3229   2013

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  • Functional and structural study of mouse sperm protein, IZUMO1, by using molecular dissection

    Naokazu Inoue, Daizo Hamada, Hironari Kamikubo, Kunio Hirata, Mikio Kataoka, Masaki Yamamoto, Masahito Ikawa, Masaru Okabe and Yoshihisa Hagihara

    Development   140 ( 15 )   3221 - 3229   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Production of mouse pups from germline transmission-failed knockout chimeras

    Yoshitaka Fujihara, Kazuhiro Kaseda, Naokazu Inoue, Masahito Ikawa, Masaru Okabe

    Transgenic Res   22 ( 1 )   195 - 200   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Genetic basis of cell-cell fusion mechanisms

    Pablo S. Aguilar*, Mary K. Baylies*, Andre Fleissner*, Laura Helming*, Naokazu Inoue*, Benjamin Podbilewicz, Hongmei Wang*, Melissa Wong* *These authors were equally contributed

    Trends Genet   29 ( 7 )   427 - 437   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Tetraspanin-interacting protein IGSF8 is dispensable for mouse fertility

    Naokazu Inoue, Takao Nishikawa, Masahito Ikawa, Masaru Okabe

    Fertil Steril   98 ( 2 )   465 - 470   2012

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    Language:English   Publishing type:Research paper (other academic)  

  • SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia

    Yoshitaka Fujihara, Yuhkoh Satouh, Naokazu Inoue, Ayako Isotani, Masahito Ikawa, Masaru Okabe

    Development   139 ( 19 )   3583 - 3589   2012

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  • Visualization of the moment of mouse sperm-egg fusion and dynamic localization of IZUMO1

    Yuhkoh Satouh*, Naokazu Inoue*, Masahito Ikawa, Masaru Okabe *The first two authors were equally contributed

    J Cell Sci   125   4985 - 4990   2012

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  • The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion

    Naokazu Inoue, Masahito Ikawa, Masaru Okabe

    Asian J Androl   13   81 - 87   2011

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  • Calsperin is a testis-specific chaperone required for sperm fertility

    Masahito Ikawa, Keizo Tokuhiro, Ryo Yamaguchi, Adam M. Benham, Taku Tamura, Ikuo Wada, Yuhkoh Satouh, Naokazu Inoue, Masaru Okabe

    J Biol Chem   286   5639 - 5646   2011

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  • Acrosome-reacted mouse spermatozoa recovered from the perivitelline space can fertilize other eggs

    Naokazu Inoue, Yuhkoh Satouh, Masahito Ikawa, Masaru Okabe, Ryuzo Yanagimachi

    Proc Natl Acad Sci USA   108   20008 - 20011   2011

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  • 精子・卵子膜融合とIZUMO1

    井上直和, 岡部勝

    J. Mamm. Ova Res   27   183 - 190   2010

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  • Sperm equatorial segment protein 1, SPESP1, is required for fully fertile sperm in mouse

    Yoshitaka Fujihara, Masao Murakami, Naokazu Inoue, Yuhkoh Satouh, Kazuhiro Kaseda, Masahito Ikawa, Masaru Okabe

    J Cell Sci   123   1531 - 1536   2010

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  • Identification and disruption of sperm-specific angiotensin converting enzyme-3 (ACE3) in mouse

    Naokazu Inoue, Tatsuya Kasahara, Masahito Ikawa, Masaru Okabe

    PLoS One   5   e10301   2010

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  • The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection

    Hiroyuki Oshiumi, Moeko Miyashita, Naokazu Inoue, Masaru Okabe, Misako Matsumoto, Tsukasa Seya

    Cell Host Microbe   8   496 - 509   2010

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  • Fertilization: a sperm's journey to and interaction with the oocyte

    Masahito Ikawa, Naokazu Inoue, Adam M Benham, Masaru Okabe

    J Clin Invest   120   984 - 994   2010

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  • 目で見るリプロダクションの基礎

    伊川正人, 井上直和, 岡部勝

    HORMONE FRONTIER IN GYNECOLOGY   9   182 - 185   2008

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  • Putative sperm fusion protein IZUMO and the role of N-glycosylation

    Naokazu Inoue, Masahito Ikawa, Masaru Okabe

    Biochem Biophys Res Commun   377   910 - 914   2008

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  • Mechanisms of sperm-egg interactions emerging from gene-manipulated animals

    Masahito Ikawa, Naokazu Inoue, Masaru Okabe

    Int J Dev Biol   52   657 - 664   2008

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  • Sperm-egg interaction and gene manipulated animals

    Naokazu Inoue, Ryo Yamaguchi, Masahito Ikawa, Masaru Okabe

    Soc Reprod Fertil Suppl   65   363 - 371   2007

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  • Positive expression of the immunoglobulin superfamily protein IZUMO on human sperm of severely infertile male patients

    Shinichi Hayasaka, Yukihiro Terada, Naokazu Inoue, Masaru Okabe, Nobuo Yaegashi, Kunihiro Okamura

    Fertil Steril   88   214 - 216   2007

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  • 受精の膜融合における必須分子Izumoの同定

    井上直和, 岡部勝

    Medical Science Digest   32 ( 10 )   416 - 417   2006

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  • Adenovirus serotype 35 vector-mediated transduction into human CD46-transgenic mice

    Fuminori Sakurai, Kenji Kawabata, Naoya Koizumi, Naokauz Inoue, Masaru Okabe, Teruhide Yamaguchi, Takao Hayakawa, Hiroyuki Mizuguchi

    Gene Ther   13   1118 - 1126   2006

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  • 受精のメカニズム -イズモを中心に卵子と精子の結合に必要な因子とその異常に関連した受精異常について-

    井上直和, 伊川正人, 岡部勝

    産科と婦人科   73 ( 6 )   735 - 742   2006

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  • 生殖と細胞接着

    伊川正人, 井上直和, 岡部勝

    Molecular Medicine   42 ( 12 )   1358 - 1367   2005

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  • The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs

    Naokazu Inoue, Masahito Ikawa, Ayako Isotani, Masaru Okabe

    Nature   434   234 - 238   2005

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  • Wild-type measles virus infection in human CD46/CD150-transgenic mice: CD11c-positive dendritic cells establish systemic viral infection

    Masashi Shingai#, Naokazu Inoue#, Tsuyoshi Okuno, Masaru Okabe, Takashi Akazawa, Yasuhide Miyamoto, Minoru Ayata, Kenya Honda, Mitsue Kurita-Taniguchi, Misako Matsumoto, Hisashi Ogura, Tadatsugu Taniguchi, Tsuakasa Seya #The first two authors were equally contributed

    J Immunol   175   3252 - 3261   2005

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  • 受精の膜融合必須分子Izumoの発見

    井上直和, 岡部勝

    細胞工学   24 ( 5 )   490 - 491   2005

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  • 受精の膜融合における必須分子Izumoの発見

    井上直和, 岡部勝

    ブレインテクノニュース   110   251 - 256   2005

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  • 受精はどこまでわかったか?

    井上直和, 山口亮, 伊川正人

    蛋白質 核酸 酵素   50 ( 11 )   1405 - 1412   2005

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  • 精子と卵子の相互作用

    井上直和, 岡部勝

    HORMONE FRONTIER IN GYNECOLOGY   11   251 - 256   2004

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  • A short consensus repeat-containing complement regulatory protein of lamprey that participates in cleavage of lamprey complement 3

    Yuko Kimura#, Naokazu Inoue#, Aya Fukui, Hiroyuki Oshiumi, Misako Matsumoto, Mayumi Nonaka, Shigeru Kuratani, Teizo Fujita, Masaru Nonaka, Tsukasa Seya #The first two authors were equally contributed

    J Immunol   173   1118 - 1128   2004

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  • Lineage-specific cell disruption in living mice by Cre-mediated expression of diphtheria toxin A chain

    Hiroyuki Matsumura, Hidetoshi Hasuwa, Naokazu Inoue, Masahito Ikawa, Masaru Okabe

    Biochem Biophys Res Commun   321   275 - 279   2004

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  • Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm

    Naokazu Inoue, Masahito Ikawa, Tomoko Nakanishi, Misako Matsumoto, Midori Nomura, Tsukasa Seya, Masaru Okabe

    Mol Cell Biol   23   2614 - 2622   2003

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  • Mechanism of host cell protection from complement in murine cytomegalovirus (CMV) infection: identification of a CMV-responsive element in the CD46 promoter region

    Midori Nomura, Mitsue Kurita-Taniguchi, Kazuhiro Kondo, Naokazu Inoue, Misako Matsumoto, Koichi Yamanishi, Masaru Okabe, Tsukasa Seya

    Eur J Immunol   32   2954 - 2964   2002

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  • Characterization of mineral deposits formed in cultures of a hamster tartrate-resistant acid phosphatase (TRAP) and alkaline phosphatase (ALP) double-positive cell line (CCP)

    Hisako Sakiyama, Takashi Nonaka, Riako Masuda, Naokazu Inoue, Yoshinori Kuboki, Mayumi Iijima, Yoshio Hirabayasi, Masahiko Takahagi, Kazuko Yoshida, Kazuko Kuriiwa, Michiteru Yoshida, Shinobu Imajoh-Ohmi

    Cell Tissue Res   309   269 - 279   2002

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  • Cloning of hamster type XVII collagen cDNA, and pathogenesis of anti-type XVII collagen antibody and complement in hamster bullous pemphigoid

    Katsushi Yamamoto, Naokazu Inoue, Riako Masuda, Akira Fujimori, Toshiyuki Saito, Shinonbu Imajoh-Ohmi, Hiroshi Shinkai, Hisako Sakiyama

    J Invest Dermatol   118   485 - 492   2002

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  • Inhibition of murine osteosarcoma cell proliferation by glucocorticoid

    Takashi Yamamoto, Miyuki Nishiguchi, Naokazu Inoue, Hiroe G Goto, Ikuo Kudawara, Takafumi Ueda, Hideki Yoshikawa, Yumiko Tanigaki, Yasuko Nishizawa

    Anticancer Res   22   4151 - 4156   2002

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  • Three soluble form messages of murine CD46 are produced through alternative mRNA splicing

    Akira Tsujimura, Kou Nunoue, Naokazu Inoue, Kyoko Shida, Mitsue Kurita-Taniguchi, Misako Matsumoto, Midori Nomura, Tatsuo Takeya, Tsukasa Seya

    J Biochem (Tokyo)   130   841 - 848   2001

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  • Molecular cloning and functional characterization of chicken toll-like receptors. A single chicken toll covers multiple molecular patterns

    Aya Fukui, Naokazu Inoue, Misako Matsumoto, Midori Nomura, Kazuhiko Yamada, Yoichi Matsuda, Kumao Toyoshima, Tsukasa Seya

    J Biol Chem   276   47143 - 47149   2001

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  • A novel chicken membrane-associated complement regulatory protein: molecular cloning and functional characterization

    Naokazu Inoue, Aya Fukui, Midori Nomura, Misako Matsumoto, Yasuko Nishizawa, Kumao Toyoshima, Tsukasa Seya

    J Immunol   166   424 - 431   2001

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  • Establishment and characterization of macrophage-like cell lines expressing osteoclast-specific markers

    Hisako Sakiyama, Riako Masuda, Naokazu Inoue, Katusi Yamamoto, Kazuko Kuriiwa, Koichi Nakagawa, Kazuko Yoshida

    J Bone Miner Metab   19   220 - 227   2001

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  • Metabolic activities of partially degenerated hypertrophic chondrocytes: gene expression of hyaluronan synthases

    Yuki Takada, Hisako Sakiyama, Kazuko Kuriiwa, Riako Masuda, Naokazu Inoue, Koichi Nakagawa, Naoki Itano, Toshiyuki Saito, Takeshi Yamada, Koji Kimata

    Cell Tissue Res   298   317 - 325   1999

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  • Selective complement C1s deficiency caused by homozygous four-base deletion in the C1s gene

    Naokazu Inoue, Toshiyuki Saito, Riako Masuda, Yoshio Suzuki, Michiko Ohtomi, Hisako Sakiyama

    Hum Genet   103   415 - 418   1998

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Books

  • 動植物の受精学

    澤田均(哺乳類における受精の分子メカニズム)

    化学同人  2014.4 

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    Responsible for pages:239-261   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:伊藤千鶴、伊藤昌彦、井上直和、年森清隆、宮戸健二   Publication place:日本  

  • Sexual Reproduction in Animals and Plants

    Hitoshi Sawada, Naokazu Inoue, Megumi Iwano(The Mechanism of Sperm-Egg Fusion in Mouse)

    Springer  2014.4 

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    Responsible for pages:393-400   Language:English  

    Authors name of the chapter and paper which it took charge of:Naokazu Inoue   Publication place:Netherlands  

  • Methods Mol Biol

    (Sperm-egg fusion assay in mammals)

    2008 

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    Responsible for pages:335-345   Language:English  

    Authors name of the chapter and paper which it took charge of:Naokazu Inoue, Masaru Okabe   Publication place:  

Presentations

  • Molecular Mechanisms leading to Gamete Fusion in Mice

    Gordon Research Conference"Fertilization and Activation of Development"   2023.7  

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    Event date: 2023.7

  • Gamete Fusion: How Spermatozoon is able to Recognize Oocyte

    Gordon Research Conference Diverse Organisms and Common Mechanisms in Cell-Cell Fusion   2022.6  

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    Event date: 2022.6

  • 配偶子融合に至る分子メカニズム

    日本アンドロロジー学会第41回学術大会   2022.6  

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    Event date: 2022.6

  • Molecular mechanisms leading to gamete fusion

    2022.5  

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    Event date: 2022.5

  • Molecular machinery of gamete fusion in mice

    2021.9  

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    Event date: 2021.9

  • 精子と卵子が出会うために必要な分子メカニズム

    内分泌・代謝学共同利用共同研究拠点ワークショップ受精・発生最前線~受精の仕組みと初期発生を支える代謝メカニズム~   2020.2  

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    Event date: 2020.2

  • 配偶子融合因子IZUMO1の2量体化を生細胞で可視化する試み

    日本動物学会・平成30年度東北支部大会  

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    Event date: 2018.7

  • Molecular machinery of sperm-egg fusion in mice

    EMBO Workshop Membrane Fusion in Health and Disease  

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    Event date: 2018.6

  • 受精の膜融合活性化メカニズム

    第6回生殖若手の会  

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    Event date: 2018.2 - 2018.3

  • Novel insights into the molecular mechanism of sperm-egg fusion via IZUMO1

    the 50th Annual Meeting of the Japanese Society of Developmental Biologists  

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    Event date: 2017.5

  • 受精の膜融合因子IZUMO1の活性化機構

    日本アンドロロジー学会 第35回学術大会  

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    Event date: 2016.6

  • 融合因子IZUMO1の構造変化による新規膜融合モデル

    第121回日本解剖学会総会  

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    Event date: 2016.3

  • 融合因子IZUMO1の構造変化による新規膜融合モデル

    第38回日本分子生物学会年会 (ワークショップ)  

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    Event date: 2015.12

  • 融合因子IZUMO1の構造変化による新規膜融合モデル

    日本動物学会第86回新潟大会  

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    Event date: 2015.9

  • Novel insights into the molecular mechanism of sperm-egg fusion via IZUMO1

    Proceedings of the 79th Annual Meeting of the Botanical Society of Japan, Niigata 2015  

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    Event date: 2015.9

  • 融合因子IZUMO1を介する受精の膜融合機構の解明

    第36回日本分子生物学会年会 (ワークショップ)  

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    Event date: 2013.12

  • The Mechanism of sperm-egg fusion in mouse and the involvement of IZUMO1

    International symposium on the mechanisms of sexual reproduction in animals and plants, Joint Meeting of the 2nd Allo-authentication Meeting and the 5th Egg-Coat Meeting  

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    Event date: 2012.11

  • The mechanism of sperm-egg fusion in mouse and the involvement of IZUMO1 and a novel factor

    Gordon Research Conferences “Cell-Cell Fusion In Sex, Life, Development and Disease"  

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    Event date: 2011.8

  • ほ乳類の融合関連因子IZUMO1の構造と局在解析

    第33回日本分子生物学会年会 (ワークショップ)  

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    Event date: 2010.12

  • 受精の膜融合における活性化メカニズム

    大阪大学蛋白質研究所セミナー 疾患と膜動態の蛋白質科学  

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    Event date: 2010.10

  • 受精の膜融合因子Izumoの膜融合活性化領域の同定とその構造解析

    第32回日本分子生物学会 (ワークショップ)  

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    Event date: 2009.12

  • ほ乳類の受精の膜融合における分子メカニズム

    第53回日本生殖医学会総会  

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    Event date: 2008.11

  • 受精の膜融合因子IzumoのN結合型糖鎖の役割

    第27回日本アンドロロジー学会  

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    Event date: 2008.8

  • 受精の膜融合における免疫グロブリンスーパーファミリーIzumoの役割

    第78回日本動物学会  

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    Event date: 2007.9

  • 受精の膜融合における免疫グロブリンスーパーファミリーIzumoの役割

    第7回日本蛋白質科学会  

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    Event date: 2007.5

  • ほ乳類の受精の膜融合における分子メカニズム

    第51回日本生殖医学会総会  

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    Event date: 2006.11

  • The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs

    JSAR-KSAR Joint Seminar “Novel Approaches to Mammalian Oocytes by Young Scientists from East Asia"  

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    Event date: 2006.9

  • The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs

    26th Annual Meeting of the American Society for Reproductive Immunology  

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    Event date: 2006.7

  • The immunoglobulin superfamily protein Izumo is required for sperm to fuse with egg

    2nd International Symposium of Institute Network  

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    Event date: 2006.5

  • 受精の膜融合に必須な分子Izumoの同定

    第20回日本生殖免疫学会  

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    Event date: 2005.12

  • Membrane cofactor protein (MCP, CD46) 欠損マウスの解析

    第17回日本生殖免疫学会  

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    Event date: 2003.12

  • Disruption of the mouse CD46 caused an accelerated spontaneous acrosome reaction in sperm

    23rd Annual Meeting of the American Society for Reproductive Immunology  

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    Event date: 2003.6

  • ニワトリの膜貫通型SCR proteinの単離と機能解析

    第37回補体シンポジウム  

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    Event date: 2001.7

  • 補体第一成分C1s欠損症の遺伝子解析

    第35回補体シンポジウム  

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    Event date: 1999.7

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Awards

  • 第4回SMF論文表彰 大賞

    2023.1  

  • 第13回インテリジェント・コスモス奨励賞

    2014.5  

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    Country:Japan

  • 第27回日本アンドロロジー学会賞

    2008.7  

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    Country:Japan

  • 平成18年度日本アンドロロジー学会学術奨励賞

    2006.7  

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    Country:Japan

  • 第20回日本生殖免疫学会賞

    2005.12  

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    Country:Japan

  • 第8回大阪大学微生物病研究所実績報告会最優秀学術賞

    2005.1  

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    Country:Japan

  • 第8回大阪大学微生物病研究所実績報告会優秀研究奨励賞

    2005.1  

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    Country:Japan

  • 第17回日本生殖免疫学会賞

    2002.11  

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    Country:Japan

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Research Projects

  • 有性生殖における生命の始まりを制御する分子メカニズムの解明 (科学研究費補助金・基盤研究 (B))

    2022.4 - 2026.3

    井上直和

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    Authorship:Principal investigator 

  • 受精の配偶子融合マシナリーの包括的解明 (科学研究費補助金・基盤研究 (B))

    2018.4 - 2022.3

    井上直和、和田郁夫

  • 哺乳類の配偶子膜融合メカニズムの解明 (アステラス病態代謝研究会研究助成)

    2017.12 - 2018.11

    井上直和、和田郁夫

  • 哺乳類の配偶子を融合させる膜因子群の分子環境とその機構 (武田科学振興財団医学系研究奨励)

    2015.8 - 2018.12

    井上直和、和田郁夫、原田英里砂

  • 配偶子膜融合活性化メカニズムの解明 (科学研究費補助金・基盤研究 (B))

    2014.4 - 2018.3

    井上直和

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    Authorship:Principal investigator 

  • 受精の膜融合活性化メカニズムの解明 (上原記念生命科学財団研究助成金)

    2014.4 - 2015.3

    井上直和、萩原義久、宮戸健二、和田郁夫

  • 受精の膜融合メカニズムの解明 (岸本基金研究助成)

    2014.4 - 2015.3

  • 哺乳類における配偶子融合の分子認証機構の解明 (科学研究費補助金・新学術領域研究「動植物に共通するアロ認証機構の解明」計画研究)

    2009.4 - 2014.3

    宮戸健二、井上直和

  • 受精の膜融合における活性化メカニズム (科学研究費補助金・若手研究 (A))

    2009.4 - 2012.3

  • ほ乳類の受精の新規膜融合因子群の分子機構 (科学研究費補助金・若手研究 (A))

    2007.4 - 2009.3

  • 細胞-細胞融合としての受精膜融合、その分子機構の解明 (科学研究費補助金・基盤研究 (C))

    2007.4 - 2009.3

    萩原義久、井上直和

  • 性質変化による透明帯の受精制御メカニズム (科学研究費補助金・特定領域研究「細胞外環境」公募研究)

    2006.4 - 2008.3

    伊川正人、井上直和

  • 精子の融合能におけるメンブレントラフィックの役割 (科学研究費補助金・特定領域研究「メンブレントラフィック」公募研究)

    2006.4 - 2008.3

  • 蛍光マウスを用いた着床のバイオイメージングと必須遺伝子の解析 (科学研究費補助金・基盤研究 (B))

    2005.4 - 2008.3

    岡部勝、井上直和

  • 小胞体レクチンシャペロンの機能破綻と受精障害 (科学研究費補助金・特定領域研究「グライコミクス」公募研究)

    2005.4 - 2007.3

    伊川正人、井上直和

  • ほ乳類の受精における融合メカニズムに必須な分子Izumoの機能解析 (科学研究費補助金・若手研究 (B))

    2005.4 - 2007.3

  • カルネキシンおよびカルレティキュリンのノックアウトマウス作製とその機能解析 (科学研究費補助金・特定領域研究「タンパク質の社会」公募研究)

    2005.4 - 2007.3

    伊川正人、井上直和

  • 精子上のイズモを介する融合機構の解析 (上原記念生命科学財団研究奨励金)

    2005.4 - 2006.3

  • ほ乳類の受精における融合因子Izumoを介する分子メカニズムの解明 (中島記念国際交流財団助成金)

    2005.4 - 2006.3

  • 精子上のIzumoを介する融合の分子メカニズムの解析 (ノバルティス研究奨励金)

    2005.4 - 2006.3

  • OBF抗原ノックアウトマウスを用いた受精の分子機構の解析 (千里ライフサイエンス振興財団奨励研究助成)

    2004.4 - 2005.3

  • カルネキシンおよびカルレティキュリンのノックアウトマウス作製とその機能解析 (科学研究費補助金・特定領域研究「タンパク質の社会」公募研究)

    2003.4 - 2005.3

    伊川正人、井上直和

  • 補体制御因子SCRタンパク質の受精と分子進化に関する研究 (科学研究費補助金・特別研究員奨励金 (PD))

    2002.4 - 2004.4

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Media Coverage

  • 脊椎動物の受精に必要な精子のタンパク質世界で初めて発見 Newspaper, magazine

    福島民報新聞  2021.5

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  • 受精に必須物質発見 Newspaper, magazine

    福島民友新聞  2021.5

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    Author:Other 

  • 精子内タンパク質安全機能を発見 男性不妊治療に期待 Newspaper, magazine

    福島民報新聞  2019.3

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    Author:Other 

  • 事故防止のシステム受精仕組みにも存在 不妊治療薬開発に期待 Newspaper, magazine

    毎日新聞  2019.3

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    Author:Other 

  • 受精遺伝子に代替機能 男性不妊治療応用期待 Newspaper, magazine

    福島民友新聞  2019.3

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    Author:Other 

  • 精子と卵子結合のカギ、たんぱく質の形解明 Newspaper, magazine

    日本経済新聞  2016.6

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    Author:Other 

  • 受精の構造明らかに 不妊治療の応用期待 Newspaper, magazine

    福島民報新聞  2016.6

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  • 受精タンパク質構造解明 避妊薬開発に期待 Newspaper, magazine

    福島民友新聞  2016.6

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    Author:Other 

  • 受精時の分子認識新メカニズム発見 避妊薬開発などに光 Newspaper, magazine

    福島民報新聞  2015.11

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  • 不妊治療法の開発期待 受精の新メカニズム Newspaper, magazine

    福島民友新聞  2015.11

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  • 精子、卵子の膜2回通過「1回限り」の定説覆す Newspaper, magazine

    日本経済新聞  2012.3

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  • The Importance of Izumo Newspaper, magazine

    2005.3

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  • 「縁結び」たんぱく質「イズモ」と命名 Newspaper, magazine

    日本経済新聞  2005.3

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  • 受精に不可欠なタンパク質 避妊法への効果期待 Newspaper, magazine

    産経新聞  2005.3

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  • 受精に不可欠たんぱく質発見 Newspaper, magazine

    読売新聞  2005.3

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    Author:Other 

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