IGARASHI Jotaro

写真a

Title

Associate Professor

Research Fields, Keywords

heme proteins, enzymology, X-ray crystallography

Mail Address

E-mail address

Current Affiliation Organization 【 display / non-display

  • Duty ,  School of Medicine (Human and Natural Sciences) ,  The Section of Molecular and Cellular Biology (Department of Natural Sciences) ,  Associate Professor

Career 【 display / non-display

  • 2004.04
    -
    2007.03

    Research Associate; Institute of Multidisciplinary Research for Advanced Materials, Tohoku University

  • 2004.08
    -
    2006.07

    Postdoctoral Researcher; University of California, Irvine

  • 2007.04
    -
    2011.02

    Assistant Professor; Institute of Multidisciplinary Research for Advanced Materials, Tohoku University

  • 2011.03
    -
    Now

    Associate Professor; Department of Natural Sciences, School of Medicine, Fukushima Medical University

Academic Society Affiliations 【 display / non-display

  • 2001.04
    -
    Now

    The Japanese Biochemical Society ,  JAPAN

  • 2006.10
    -
    Now

    The Biophysical Society of Japan ,  JAPAN

  • 2013.09
    -
    Now

    Japan Radioisotope Association ,  JAPAN

Field of expertise (Grants-in-aid for Scientific Research classification) 【 display / non-display

  • Functional Biochemistry

  • Radiation/Chemical Substance Influence Science

  • Structural Biochemistry

 

Papers 【 display / non-display

  • Hydrogen sulfide stimulates the catalytic activity of a heme-regulated phosphodiesterase from Escherichia coli (Ec DOS)

    Takahashi, H., Sekimoto, M., Tanaka, M., Tanaka, A., Igarashi, J., and Shimizu, T.

    Journal of Inorganic Biochemistry ,  109   66 - 71 ,  2012.04

    Multiple Authorship

    DOI

  • Leu65 in the heme distal side is critical for the stability of the Fe(II)-O2 complex of YddV, a globin-coupled oxygen sensor diguanylate cyclase

    Nakajima, K., Kitanishi, K., Kobayashi, K., Kobayashi, N., Igarashi, J., and Shimizu, T

    J. Inorg. Biochem. ,  108   163 - 170 ,  2012.03

    Multiple Authorship

    DOI

  • Identification and functional and spectral characterization of a globin-coupled histidine kinase from Anaeromyxobacter sp. Fw109-5

    Kitanishi, K., Kobayashi, K., Uchida, T., Ishimori, K., Igarashi, J., and Shimizu, T.

    J. Biol. Chem. ,  286 (41) 35522 - 35534 ,  2011.08

    Multiple Authorship

    DOI

  • Phosphorylation of a heme-regulated eukaryotic initiation factor 2α kinase enhances the interaction with heat-shock protein 90 and substantially upregulates kinase activity

    Mukai, K., Shimizu, T., and Igarashi, J.

    Protein Pept. Lett. ,  18 (12) 1251 - 1257 ,  2011.07

    Multiple Authorship

    DOI

  • A hydrogen-bonding network formed by the B10-E7-E11 residues of a truncated hemoglobin from Tetrahymena pyriformis is critical for stability of bound oxygen and nitric oxide detoxification

    Igarashi, J., Kobayashi, K., and Matsuoka, A.

    J. Biol. Inorg. Chem. ,  16 (4) 599 - 609 ,  2011.05

    Multiple Authorship

    DOI

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Books 【 display / non-display

  • Circadian Rhythms: Biology, Cognition and Disorders

    L. Golovlin, A. Maliszkewicz (Part:Emerging functions of heme in transcription associated with circadian rhythms) (Page:225-245)

    Nova Science ,  2012 ,  ISBN: 978-1-61470-010-4

    Kitanishi, K., Hayasaka, K., Harada, M., Nagata, R., Igarashi, J., Shimizu, T. ,  Hauppauge, NY, USA

  • Gas Sensors: Developments, Efficacy and Safety

    (Part:Novel effects of Mn2+ on the catalytic enhancement of the inactive form of the Fe(III) heme-bound Ec DOS, a heme-regulated phosphodiesterase from Escherichia coli) (Page:251-261)

    Nova Science ,  2012 ,  ISBN: 978-1-61470-829-2

  • Circadian Rhythms: Biology, Cognition and Disorders

    (Part:Heme binding characteristics of mouse Per1, a transcriptional regulatory factor associated with circadian rhythms) (Page:133-160)

    Nova Science ,  2012 ,  ISBN: 978-1-61470-010-4

  • Handbook of Porphyrin Science

    (Part:Emerging Role of Heme as a Signal and the Gas-Sensing Site: Heme-Sensing and Gas-Sensing Proteins) (Page:399-460)

    World Scientific ,  2011.02 ,  ISBN: 978-981-4322-32-4

Presentations 【 display / non-display

  • Hoki myoglobin with unusual autoxidation behavior: Comparative analysis of native protein and H60V mutant.

    The 22nd International Congress of Zoology and the 87th meeting of Zoological Society of Japan , 

    2016.11
     
     

  • Ligand sensing mechanism of globin domain of a heme-based oxygen-sensor enzyme, YddV, from Escherichia coli

    XIXth International Conference of Oxygen Binding and Sensing Protein , 

    2016.09
     
     

  • Crystal structure of isolated heme-bound globin domain of a heme-based oxygen-sensor, YddV, from Escherichia coli

    第53回日本生物物理学会年会 , 

    2015.09
     
     

  • Stability properties of myoglobin in the Argentinian hoki (Macruronus magellanicus).

    The 9th International Congress of Comparative Physiology and Biochemistry , 

    2015.08
     
     

  • Molecular mechanism of NO-induced catalytic activation of mouse heme-regulated eukaryotic initiation factor 2α kinase, HRI

    Pacifichem 2010 Congress , 

    2010.12
     
     

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Charge of on-campus class subject 【 display / non-display

  • Basic Biology

  • Natural Sciences

  • Molecular Genetics

  • Tutorial III

  • Tutorial II

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