Updated on 2024/01/19

写真a

 
CHIBA Hideki
 
Organization
School of Medicine (Life Sciences and Social Medicine) Department of Basic Pathology Professor
Title
Professor

Research Interests

  • Cell adhesion,Tight junction, Claudin, Nuclear receptor, Signal transduction, Stem cells, Cancer, Biomarker

Research Areas

  • Life Science / Experimental pathology  / Experimental Pathology

  • Life Science / Cell biology  / Cell Biology

Research History

  • Fukushima Medical University   Professor

    2017.2 - Now

Papers

  • Aberrant phosphorylation of human LRH1 at serine 510 is predictable of hepatocellular carcinoma recurrence.

    Nishimagi A, Kobayashi M, Sugimoto K, Kofunato Y, Sato N, Haga J, Ishigame T, Kimura T, Kenjo A, Kobayashi Y, Hashimoto Y, Marubashi S, Chiba H

    Clinical and experimental medicine   23 ( 8 )   4985 - 4995   2023.12( ISSN:1591-8890

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    Language:English  

    DOI : 10.1007/s10238-023-01098-x

    PubMed

  • ZnUMBA - a live imaging method to detect local barrier breaches.

    Higashi T, Stephenson RE, Schwayer C, Huljev K, Higashi AY, Heisenberg CP, Chiba H, Miller AL

    Journal of cell science   136 ( 15 )   2023.8( ISSN:0021-9533

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    DOI : 10.1242/jcs.260668

    PubMed

  • The Src-Family Kinases SRC and BLK Contribute to the CLDN6-Adhesion Signaling.

    Ichikawa-Tomikawa N, Sugimoto K, Kashiwagi K, Chiba H

    Cells   12 ( 13 )   2023.6

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    DOI : 10.3390/cells12131696

    PubMed

  • Tight-junction strand networks and tightness of the epithelial barrier

    Saito Akira C., Higashi Tomohito, Chiba Hideki

    Microscopy   72 ( 3 )   213 - 225   2023.6( ISSN:2050-5698

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  • SPON1 is an independent prognostic biomarker for ovarian cancer.

    Miyakawa R, Kobayashi M, Sugimoto K, Endo Y, Kojima M, Kobayashi Y, Furukawa S, Honda T, Watanabe T, Asano S, Soeda S, Hashimoto Y, Fujimori K, Chiba H

    Journal of ovarian research   16 ( 1 )   95   2023.5

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    DOI : 10.1186/s13048-023-01180-8

    PubMed

  • Claudin-4-adhesion signaling drives breast cancer metabolism and progression via liver X receptor β.

    Murakami-Nishimagi Y, Sugimoto K, Kobayashi M, Tachibana K, Kojima M, Okano M, Hashimoto Y, Saji S, Ohtake T, Chiba H

    Breast cancer research : BCR   25 ( 1 )   41   2023.4( ISSN:1465-5411

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    DOI : 10.1186/s13058-023-01646-z

    PubMed

  • Tight-junction strand networks and tightness of the epithelial barrier.

    Saito AC, Higashi T, Chiba H

    Microscopy (Oxford, England)   2023.1( ISSN:2050-5698

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    DOI : 10.1093/jmicro/dfad008

    PubMed

  • EpCAM proteolysis and release of complexed claudin-7 repair and maintain the tight junction barrier.

    Higashi T, Saito AC, Fukazawa Y, Furuse M, Higashi AY, Ono M, Chiba H

    The Journal of cell biology   222 ( 1 )   2023.1( ISSN:0021-9525

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    DOI : 10.1083/jcb.202204079

    PubMed

  • Claudin‑9 is a novel prognostic biomarker for endometrial cancer.

    Endo Y, Sugimoto K, Kobayashi M, Kobayashi Y, Kojima M, Furukawa S, Soeda S, Watanabe T, Higashi AY, Higashi T, Hashimoto Y, Fujimori K, Chiba H

    International journal of oncology   61 ( 5 )   2022.11( ISSN:1019-6439

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    DOI : 10.3892/ijo.2022.5425

    PubMed

  • 臨床検体を用いたバイオマーカー研究 がん自己抗体研究の軌跡

    小林 信, 杉本 幸太郎, 千葉 英樹

    電気泳動   66 ( 1 )   43 - 46   2022.10( ISSN:2189-2628

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    Language:Japanese  

  • Effects of TAMP family on the tight junction strand network and barrier function in epithelial cells.

    Saito AC, Endo C, Fukazawa Y, Higashi T, Chiba H

    Annals of the New York Academy of Sciences   2022.9( ISSN:0077-8923

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    DOI : 10.1111/nyas.14889

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  • LXRβ Activation Inhibits the Proliferation of Small-cell Lung Cancer Cells by Depleting Cellular Cholesterol.

    Kashiwagi K, Sato-Yazawa H, Ishii J, Kohno K, Tatsuta I, Miyazawa T, Takagi M, Chiba H, Yazawa T

    Anticancer research   42 ( 6 )   2923 - 2930   2022.6( ISSN:0250-7005

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    DOI : 10.21873/anticanres.15774

    PubMed

  • Aberrant expression of claudin-6 contributes to malignant potentials and drug resistance of cervical adenocarcinoma.

    Ito Y, Takasawa A, Takasawa K, Murakami T, Akimoto T, Kyuno D, Kawata Y, Shano K, Kirisawa K, Ota M, Aoyama T, Murata M, Sugimoto K, Chiba H, Saito T, Osanai M

    Cancer science   113 ( 4 )   1519 - 1530   2022.4( ISSN:1347-9032

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    DOI : 10.1111/cas.15284

    PubMed

  • Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland.

    Higashi AY, Higashi T, Furuse K, Ozeki K, Furuse M, Chiba H

    Scientific reports   11 ( 1 )   21642   2021.11

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    DOI : 10.1038/s41598-021-01004-z

    PubMed

  • The region-selective regulation of endothelial claudin-5 expression and signaling in brain health and disorders.

    Chiba H, Ichikawa-Tomikawa N, Imura T, Sugimoto K

    Journal of cellular physiology   236 ( 10 )   7134 - 7143   2021.10( ISSN:0021-9541

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    DOI : 10.1002/jcp.30357

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  • Aberrant claudin-6-adhesion signaling promotes endometrial cancer progression via estrogen receptor α.

    Kojima M, Sugimoto K, Kobayashi M, Ichikawa-Tomikawa N, Kashiwagi K, Watanabe T, Soeda S, Fujimori K, Chiba H

    Molecular cancer research : MCR   19 ( 7 )   1208 - 1220   2021.7( ISSN:1541-7786

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    DOI : 10.1158/1541-7786.MCR-20-0835

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  • CLDN15 is a novel diagnostic marker for malignant pleural mesothelioma.

    Watanabe M, Higashi T, Ozeki K, Higashi AY, Sugimoto K, Mine H, Takagi H, Ozaki Y, Muto S, Okabe N, Matsumura Y, Hasegawa T, Shio Y, Suzuki H, Chiba H

    Scientific reports   11 ( 1 )   12554   2021.6

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    DOI : 10.1038/s41598-021-91464-0

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  • The claudin-transcription factor signaling pathway.

    Sugimoto K, Chiba H

    Tissue barriers   9 ( 3 )   1908109   2021.4( ISSN:2168-8362

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    DOI : 10.1080/21688370.2021.1908109

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  • Bacterial Myocarditis in a Patient with Cancer.

    Yamashita R, Tanaka M, Chiba H, Sugimoto K

    JMA journal   4 ( 2 )   169 - 170   2021.4( ISSN:2433-328X

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    DOI : 10.31662/jmaj.2020-0082

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  • Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function.

    Saito AC, Higashi T, Fukazawa Y, Otani T, Tauchi M, Higashi AY, Furuse M, Chiba H

    Molecular biology of the cell   32 ( 8 )   722 - 738   2021.4( ISSN:1059-1524

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    DOI : 10.1091/mbc.E20-07-0464

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  • Reduced claudin-12 expression predicts poor prognosis in cervical cancer

    Rahman A., Kobayashi M., Sugimoto K., Endo Y., Kojima M., Furukawa S., Watanabe T., Soeda S., Hashimoto Y., Fujimori K., Chiba H.

    International Journal of Molecular Sciences   22 ( 7 )   3774   2021.4( ISSN:16616596

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.3390/ijms22073774

  • Soluble jam-c ectodomain serves as the niche for adipose-derived stromal/stem cells

    Yamazaki M., Sugimoto K., Mabuchi Y., Yamashita R., Ichikawa-Tomikawa N., Kaneko T., Akazawa C., Hasegawa H., Imura T., Chiba H.

    Biomedicines   9 ( 3 )   278   2021.3

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    DOI : 10.3390/biomedicines9030278

  • Protection of Fatty Liver by the Intake of Fermented Soybean Paste, <i>Miso</i>, and Its Pre-Fermented Mixture.

    Kanno R, Koshizuka T, Miyazaki N, Kobayashi T, Ishioka K, Ozaki C, Chiba H, Suzutani T

    Foods (Basel, Switzerland)   10 ( 2 )   291   2021.2

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    DOI : 10.3390/foods10020291

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  • Serotonin/5-HT1A Signaling in the Neurovascular Unit Regulates Endothelial CLDN5 Expression.

    Sugimoto K, Ichikawa-Tomikawa N, Nishiura K, Kunii Y, Sano Y, Shimizu F, Kakita A, Kanda T, Imura T, Chiba H

    International journal of molecular sciences   22 ( 1 )   1 - 11   2020.12( ISSN:16616596

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.3390/ijms22010254

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  • Prognostic Significance of Aberrant Claudin-6 Expression in Endometrial Cancer.

    Kojima M, Sugimoto K, Tanaka M, Endo Y, Kato H, Honda T, Furukawa S, Nishiyama H, Watanabe T, Soeda S, Fujimori K, Chiba H

    Cancers   12 ( 10 )   1 - 11   2020.9

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    DOI : 10.3390/cancers12102748

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  • Molecular organization, regulation and function of tricellular junctions

    Higashi T, Chiba H

    Biochim Biophys Acta   1862 ( 2 )   183143   2019.12

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    DOI : 10.1016/j.bbamem.2019.183143

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  • Cell adhesion signals regulate the nuclear receptor activity.

    Sugimoto K, Ichikawa-Tomikawa N, Kashiwagi K, Endo C, Tanaka S, Sawada N, Watabe T, Higashi T, Chiba H

    Proceedings of the National Academy of Sciences of the United States of America   116 ( 49 )   24600 - 24609   2019.12( ISSN:0027-8424

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    DOI : 10.1073/pnas.1913346116

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  • Myocardial Rupture Due to Metastasis of Urothelial Carcinoma.

    Sugimoto K, Tanaka M, Chiba H

    Circulation journal : official journal of the Japanese Circulation Society   83 ( 4 )   839   2019.3( ISSN:1346-9843

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    DOI : 10.1253/circj.CJ-18-0669

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  • 尿路上皮癌の転移に起因する心筋破裂(Myocardial Rupture Due to Metastasis of Urothelial Carcinoma)

    Sugimoto Kotaro, Tanaka Mizuko, Chiba Hideki

    Circulation Journal   83 ( 4 )   839 - 839   2019.3( ISSN:1346-9843

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  • Differential expression of a stress-regulated gene Nr4a2 characterizes early- and late-born hippocampal granule cells.

    Imura T, Kobayashi Y, Suzutani K, Ichikawa-Tomikawa N, Chiba H

    Hippocampus   2018.10( ISSN:1050-9631

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    DOI : 10.1002/hipo.23045

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  • 病気と深くかかわる上皮細胞の「細胞間接着分子」

    千葉英樹

    ヘルシスト   250   8 - 11   2018.7

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  • A novel occludin-targeting monoclonal antibody prevents hepatitis C virus infection <i>in vitro</i>.

    Okai K, Ichikawa-Tomikawa N, Saito AC, Watabe T, Sugimoto K, Fujita D, Ono C, Fukuhara T, Matsuura Y, Ohira H, Chiba H

    Oncotarget   9 ( 24 )   16588 - 16598   2018.3

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    DOI : 10.18632/oncotarget.24742

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  • Expression of liver X receptors in normal and refractory carcinoma tissues of the human lung and pancreas.

    Kashiwagi K, Yanagida M, Matsui D, Tanaka M, Sugimoto K, Chen H, Ichikawa-Tomikawa N, Marubashi S, Suzuki H, Chiba H

    Histology and histopathology   11949   2017.11( ISSN:0213-3911

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    DOI : 10.14670/HH-11-949

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  • PKA activation and endothelial claudin-5 breakdown in the schizophrenic prefrontal cortex.

    Nishiura K, Ichikawa-Tomikawa N, Sugimoto K, Kunii Y, Kashiwagi K, Tanaka M, Yokoyama Y, Hino M, Sugino T, Yabe H, Takahashi H, Kakita A, Imura T, Chiba H

    Oncotarget   8 ( 55 )   93382 - 93391   2017.11

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    DOI : 10.18632/oncotarget.21850

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  • Molecular characterization of human osteoblast-derived extracellular vesicle mRNA using next-generation sequencing.

    Morhayim J, van de Peppel J, Dudakovic A, Chiba H, van Wijnen AJ, van Leeuwen JP

    Biochimica et biophysica acta   1864 ( 7 )   1133 - 1141   2017.7( ISSN:0006-3002

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    DOI : 10.1016/j.bbamcr.2017.03.011

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  • Osteoblasts secrete miRNA-containing extracellular vesicles that enhance expansion of human umbilical cord blood cells

    Morhayim J, van de Peppel J, Braakman E, Rombouts E, ter Borg M, Dudakovic A, Chiba H, van der Eerden BC, Raaijmakers M, van Wijnen A, Cornelissen J, Leeuwen JP

    Sci Rep   6   32034   2016.9

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  • Methionine aminopeptidase 2 as a potential therapeutic target for human non-small cell lung cancers

    Shimizu H, Yamagishi S, Chiba H, Ghazizadeh M

    Adv Clin Exp Med   25   117 - 128   2016

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  • Liver X receptor reduces proliferation of human oral cancer cells by promoting cholesterol efflux via up-regulation of ABCA1 expression.

    Kaneko T, Kanno C, Ichikawa-Tomikawa N, Kashiwagi K, Yaginuma N, Ohkoshi C, Tanaka M, Sugino T, Imura T, Hasegawa H, Chiba H

    Oncotarget   6 ( 32 )   33345 - 57   2015.10

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    DOI : 10.18632/oncotarget.5428

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  • Expression and Function of LPA1 in Bladder Cancer.

    Kataoka M, Ishibashi K, Kumagai S, Yanagida T, Aikawa K, Chiba H, Kojima Y

    The Journal of urology   194 ( 1 )   238 - 44   2015.7( ISSN:0022-5347

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    DOI : 10.1016/j.juro.2014.12.028

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  • The liver X receptor reduces proliferation of human oral cancer cells by promoting cholesterol efflux via up-regulation of ABCA1 expression

    Kaneko T, Kanno C, Ichikawa-Tomikawa N, Kashiwagi K, Yaginuma N, Ohkoshi C, Tanaka M, Sugino T, Imura T, Hasegawa H, Chiba H

    Oncotarget   6   33345 - 33357   2015

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  • Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth

    Morhayim J, van de Peppel J, Demmers JA, Kocer G, Nigg AL, van Driel M, Chiba H, van Leeuwen JP

    FASEB J   29   274 - 285   2015

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  • Co-expression of S100A14 and S100A16 correlates with a poor prognosis in human breast cancer and promotes cancer cell invasion

    Tanaka M, Ichikawa-Tomikawa N, Shishito N, Nishiura K, Miura T, Hozumi A, Chiba H, Yoshida S, Ohtake T, Sugino T

    MBC Cancer   15   53   2015

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  • Expression and function of lysophosphatidic acid receptor 1 in bladder cancer

    Kataoka M, Ishibashi K, Kumagai S, Yanagida T, Aikawa K, Chiba H, Kojima Y

    J Urol   194   238 - 244   2015

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  • 細胞接着装置-構造・機能と疾患との関わり-

    冨川直樹, 杉本幸太郎, 柏木維人, 田中瑞子, 井村徹也, 千葉英樹

    病理と臨床   32 ( 5 )   563 - 568   2014.5

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  • 病理と基礎生命科学の接点(第2回) 細胞接着装置 構造・機能と疾患との関わり

    冨川 直樹, 杉本 幸太郎, 柏木 維人, 田中 瑞子, 井村 徹也, 千葉 英樹

    病理と臨床   32 ( 5 )   563 - 568   2014.5( ISSN:0287-3745

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  • 幹細胞の新規上皮分化誘導機構の解明

    千葉 英樹

    上原記念生命科学財団研究報告集   27   1 - 6   2013.12

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  • The tight-junction protein claudin-6 induces epithelial differentiation from mouse F9 and embryonal stem cells

    Sugimoto K, Ichikawa-Tomikawa N, Satohisa S, Akashi Y, Kanai R, Saito T, Sawada N, Chiba H

    PLoS ONE   8   e75106   2013.10

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  • The Tight-Junction Protein Claudin-6 Induces Epithelial Differentiation from Mouse F9 and Embryonic Stem Cells

    Sugimoto K., Ichikawa-Tomikawa N., Satohisa S., Akashi Y., Kanai R., Saito T., Sawada N., Chiba H.

    PLoS ONE   8 ( 10 )   2013.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1371/journal.pone.0075106

  • 1α,25-Dihydroxyvitamin D3 and rosiglitazone synergistically enhance osteoblast-mediated mineralization

    Woeckel V., Bruedigam C., Koedam M., Chiba H., van der Eerden B., van Leeuwen J.

    Gene   512 ( 2 )   438 - 443   2013.1( ISSN:03781119

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    DOI : 10.1016/j.gene.2012.07.051

  • Evidence of vitamin D and interferon-beta cross-talk in human osteoblasts with 1alpha,25-dihydroxyvitamin D3 and rosigliatazone synergistically osteoblast-mediated mineralization

    Woeckel VJ, Bruedigam C, Koedam M, Chiba H, van der Eerden BC, van Leeuwen JP

    Gene   438 - 443   2013

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  • Stereotaxic injectionの手法と応用

    冨川(市川)直樹, 千葉英樹

    Surgery Frontier   19 ( 4 )   445 - 450   2012.12

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  • 蛍光ダイレクトラベリングによる生細胞蛍光イメージング

    冨川(市川)直樹, 千葉英樹

    Surgery Frontier   19 ( 3 )   335 - 340   2012.9

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  • Evidence of vitamin D and interferon-betacross-talk in human osteoblasts with 1alpha,25-dihydroxyvitamin D3 being dominant over interferon-beta in stimulating mineralization

    Woeckel VJ, Eijken M, van de Peppel J, Chiba H, van der Eerden BC, van Leeuwen JP

    J Cell Physiol   227   3258 - 3266   2012

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  • Claudin-4-targeted therapy using Clostridium Perfringens enterotoxin for prostate cancer

    Maeda T, Murata M, Chiba H, Takasawa A, Tanaka S, Kojima T, Masumori N, Tsukamoto T, Sawada N

    Prostate   72   351 - 360   2012

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  • Laminin alpha1 is essential for mouse cerebellar development

    Ichikawa-Tomikawa N, Ogawa J, Douet V, Xu Z, Kamikubo Y, Sakurai T, Kohsaka S, Chiba H, Hattori N, Yamada Y, Arikawa-Hirasawa E

    Matrix Biol   31   17 - 28   2012

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  • The transient potential channel TRPV6 is dynamically expressed in bone cells but in not crucial for bone mineralization in mice

    van der Eerden BC, Weissgerber P, Fratzl-Zelman N, Olausson J, Hoenderop JG, Schreuders-Koedam M, Eijken M, Roschger P, de Vries TJ, Chiba H, Klaushofer K, Flockerzi V, Bindels RJ, Freichel M, van Leeuwen JP

    J Cell Physiol   227   1951 - 1959   2012

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  • IFNbeta impairs extracellular matrix formation leading to inhibition of mineralization by effects in the early stage of human osteoblast differentiation

    Woeckel VJ, Eijken M, van de Peppel J, Chiba H, van der Eerden BC, van Leeuwen JP

    J Cell Physiol   227   2668 - 2676   2012

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  • Possible involevement of tight junctions, extracellular matrix and nuclear receptors in epithelial differentiation

    Ichikawa-Tomikawa N, Sugimoto K, Satohisa S, Nishiura K, Chiba H

    J Biomed Biotechnol   2011   253048   2011

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  • Opposing actions of rosiglitazone and resveratrol on mineralization in human vascular smooth muscle cell

    Bruedigam C, Eijken M, Koedam M, Chiba H, van Leeuwen JP

    J Mol Cell Cardiol   51   862 - 871   2011

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  • 1alpha,25-(OH)2D3 acts in the early phase of osteoblast differentiation to enhance mineralization via accelerated production of mature matrix vesicles.

    Woeckel V, Alves R, Swagemakers S, Eijken M, , Chiba H, van der Eerden BC, van Leeuwen JP.

    J Cell Physiol   225 ( 2 )   593 - 600   2010.11

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  • Proteomic Analysis of Human Osteoblastic Cells: Relevant Proteins and Functional Categories for Differentiation.

    Alves RD, Eijken M, Swagemakers S, Chiba H, Titulaer MK, Burgers PC, Luider TM, van Leeuwen JP.

    J Proteome Res,   9 ( 9 )   4688 - 4700   2010.9

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  • A new concept underlying stem cell lineage skewing that explains the detrimental effecots of thiazolidinediones on bone.

    Bruedigam C, Eijken M, Koedam M, van de Peppel J, Drabek K, Chiba H, van Leeuwen JP.

    Stem Cells   28 ( 5 )   916 - 927   2010.5

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  • Stretch-induced inhibition of Wnt/beta-catenin signaling in mineralizing osteoblasts.

    Jansen JH, Eijken M, Jahr H, Chiba H, Verhaar JA, van Leeuwen JP, Weinans H.

    28 ( 3 )   390 - 396   2010.3

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  • タイト結合を介したミネラル輸送調節

    杉本幸太郎, 藤田裕樹, 稲富周一郎, 澤田典均, 千葉英樹

    腎と骨代謝   23   145 - 147   2010

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  • Thymic stromal lymphopoietin enhances tight-junction barrier function of human nasal epithelial cells.

    Kamekura R, Kojima T, Koizumi J, Ogasawara N, Kurose M, Go M, Harimaya A, Murata M, Tanaka S, Chiba H, Himi T, Sawada N.

    Cell Tissue Res   338 ( 2 )   283 - 93   2009.11

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  • Tight junction proteins and signal transduction pathways in hepatocytes.

    Kojima T, Murata M, Yamamoto T, Lan M, Imamura M, Son S, Takano K-i, Yamaguchi H, Ito T, Tanaka S, Chiba H, Hirata K, Sawada N.

    Histol Histopathol   24 ( 11 )   1463 - 1472   2009.11

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  • Spinal cord infarct as the initial clinical presentation of intravascular malignant lymphomatosis.

    Liu H, Koyanagi I, Chiba H, Wanibuchi M, Honmou O, Yamaki T, Houkin K.

    J Clin Neurosci   16 ( 4 )   570 - 573   2009.4

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  • Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells.

    Son S, Kojima T, Decaens C, Yamaguchi H, Ito T, Imamura M, Murata M, Tanaka S, Chiba H, Hirata K, Sawada N.

    Histochem Cell Biol   131 ( 3 )   411 - 424   2009.3

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  • Transforming growth factor-βinduces epithelial to mesenchymal transition by down-regulation of claudin-1 expression and the fence function in adult rat hepatocytes.

    Kojima T, Takano K, Yamamoto T, Imamura M, Murata M, Son S, Yamaguchi H, Osanai M, Chiba H, Himi T, Sawada N.

    Liver Int   28 ( 4 )   534 - 545   2008.4

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  • Cdx2 transcription factor regulates claudin-3 and claudin-4 expression during intestinal differentiation of gastric carcinoma.

    Satake S, Semba S, Matsuda Y, Usami Y, Chiba H, Sawada N, Kasuga M, Yokozaki H.

    Pathol Int   58 ( 3 )   156 - 163   2008.3

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  • Transmembrane proteins of tight junctions.

    Chiba H, Osanai M, Murata M, Kojima T, Sawada N.

    BBA-Biomembranes,   1778   588 - 600   2008

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  • IGF-I regulates tight-junction protein claudin-1 during differentiation of osteoblast-like MC3T3-E1 cells via a MAP-kinase pathway.

    Hatakeyama N, Kojima T, Iba K, Murata M, Thi MM, Spray DC, Osanai M, Chiba H, Ishii S, Yamashita T, Sawada N.

    Cell Tissue Res   334   243 - 254   2008

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  • Evidence for multiple peroxisome proliferator-activated receptor gamma transcripts in bone: Fine-tuning by hormonal regulation and mRNA stability.

    Bruedigam C, Koedam M, Chiba H, Eijken M, van Leeuwen JP.

    FEBS Lett   582   1618 - 1624   2008

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  • Experimental effect of retinoic acids on apoptosis during the development of diabetic retinopathy.

    Nishikiori N, Osanai M, Chiba H, Kojima T, Inatomi S, Ohguro H, Sawada N.

    Clinical Ophthalmology   2   233 - 235   2008

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  • Protein kinase C enhances tight junction barrier function of human nasal epithelial cells in primary culture by transcriptional regulation.

    Koizumi J, Kojima T, Ogasawara N, Kamekura R, Kurose M, Go M, Harimaya A, Murata M, Osanai M, Chiba H, Himi T, Sawada N.

    Mol Pharmacol   74   432 - 442   2008

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  • Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes.

    Fujita H, Sugimoto K, Inatomi S, Maeda T, Osanai M, Uchiyama Y, Yamamoto Y, Wada T, Kojima T, Yokozaki H, Yamashita T, Kato S, Sawada N, Chiba H.

    Mol Biol Cell,   19   1912 - 1921   2008

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  • Wnt signaling acts and is regulated in a human osteoblast differentiation dependent manner.

    Eijken M, Meijer IM, Westbroek I, Koedam M, Chiba H, Uitterlinden AG, Pols HA, van Leeuwen JP.

    J Cell Biochem   104   568 - 579   2008

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  • Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro.

    J Mol Histol   39 ( 3 )   265 - 273   2008

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  • Hypermethylation-modulated downregulation of claudin-7 expression promotes the progression of colorectal carcinoma.

    Nakayama F, Semba S, Usami Y, Chiba H, Sawada N, Yokozaki H.

    Pathobiology   75 ( 3 )   177 - 185   2008

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  • A novel occludin-targeting monoclonal antibody prevents hepatitis C virus infection in vitro

    Okai K, Ichikawa-Tomikawa N, Saito AC, Watabe T, Sugimoto K, Fujita D, Ono T, Fukuhara T, Matsuura Y, Ohira H, Chiba H

    Oncotarget   2008

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  • 経過中に筋萎縮性側索硬化症(ALS)を発症した進行大腸癌の1部検例

    佐藤康史,高山哲治,二階堂ともみ,和田優子,佐川保,阿部清一郎,佐藤勉,井山諭,村瀬和幸,荒木啓伸,佐藤康裕,加藤淳二,新津洋司郎,千葉英樹.

    日消誌   104   1365 - 1370   2007

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  • Induction of claudins in passaged hTERT-transfected human nasal epithelial cells with an extended life span.

    Kurose M, Kojima T, Koizumi J, Kamekura R, Ninomiya T, Murata M, Ichimiya S, Osanai M, Chiba H, Himi T, Sawada N.

    Cell Tissue Res   330   63 - 74   2007

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  • Changes of gap and tight junctions during differentiation of human nasal epithelial cells using primary human nasal epithelial cells and primary human nasal fibroblast cells in a noncontact coculture system.

    Koizumi J, Kojima T, Kamekura R, Kurose M, Harimaya A, Murata M, Osanai M, Chiba H, Himi T, Sawada N.

    J Membr Biol   218   1 - 7   2007

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  • Epigenetic silencing of claudin-6 promotes anchorage-independent growth of breast carcinoma cells.

    Osanai M, Murata M, Chiba H, Kojima T, Sawada N.

    Cancer Sci   98   1557 - 1562   2007

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  • Occludin-mediated premature senescence is a fail-safe mechanism against tumorigenesis in breast carcinoma cells.

    Osanai M, Murata M, Nishikiori N, Chiba H, Kojima T, Sawada N.

    Cancer Sci   98   1027 - 1034   2007

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  • Gastric and intestinal claudins expression at the invasive front of gastric carcinoma.

    Matsuda Y, Semba S, Ueda J, Fuku T, Hasuo T, Chiba H, Sawada N, Kuroda Y, Yokozaki H.

    Cancer Sci   98   1014 - 1019   2007

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  • Oncostatin M induces upregulation of claudin-2 in rodent hepatocytes coinciding with changes in morphology and function of tight junctions.

    Imamura M, Kojima T, Lan M, Son S, Murata M, Osanai M, Chiba H, Hirata K, Sawada N.

    Exp Cell Res   313   1951 - 1962   2007

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  • A novel monoclonal antibody against second extracellular loop of occludin disrupts epithelial cell polarity.

    Tokunaga Y, Kojima T, Osanai M, Murata M, Chiba H, Tobioka H, Sawada N.

    J Histochem Cytochem   55   735 - 744   2007

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  • Glial cell-derived cytokines attenuate the breakdown of vascular integrity in diabetic retinopathy.

    Nishikiori N, Osanai M, Chiba H, Kojima T, Mitamura Y, Ohguro H, Sawada N.

    Diabetes   56   1333 - 1340   2007

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  • Inhibitory effects of retinoic acid receptor alpha stimulants on murine cataractogenesis through suppression of deregulated calpains.

    Nishikiori N, Osanai M, Chiba H, Kojima T, Ohguro H, Sawada N.

    Invest Ophth Vis Sci   48   2224 - 2229   2007

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  • Heterogeneous expression of claudin-4 in human colorectal cancer: decreased claudin-4 expression at the invasive front correlates cancer invasion and metastasis.

    Ueda J, Semba S, Chiba H, Sawada N, Seo Y, Kasuga M, Yokozaki H.

    Pathobiology   74   32 - 41   2007

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  • Expression patterns of claudin family of tight-junction proteins in the mouse prostate.

    Sakai N, Chiba H, Fujita H, Akashi Y, Osanai M, Kojima T, Sawada N.

    Histochem Cell Biol   127   457 - 462   2007

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  • Cellular retinoic acid bioavailability determines epithelial integrity: role of retinoic acid receptor alpha agonists in colitis.

    Osanai M, Nishikiori N, Murata M, Chiba H, Kojima T, Sawada N.

    Mol Pharmacol   71   250 - 258   2007

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  • Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells.

    Nagasawa K, Chiba H, Fujita H, Kojima T, Saito T, Endo T, Sawada N.

    J Cell Physiol   208   123 - 132   2006

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  • The significance of interferon-&#61543;-triggered internalization of tight-junction proteins in inflammatory bowel disease.

    Sci STKE   316: pe1   2006

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  • The nuclear receptor hepatocyte nuclear factor 4&#61537;&#61472;acts as a morphogen to induce the formation of microvilli.

    Chiba H, Sakai N, Murata M, Osanai M, Ninomiya T, Kojima T, Sawada N.

    J Cell Biol   175   971 - 980   2006

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  • Epigenetic silencing of occludin promotes tumorigenic and metastatic properties of cancer cells via modulations of unique sets of apoptosis-associated genes.

    Osanai M, Murata M, Nishikiori N, Chiba H, Kojima T, Sawada N.

    Cancer Res   66   9125 - 9133   2006

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  • Connexin 26 expression prevents down-regulation of barrier and fence functions of tight junctions by Na+/K+-ATPase inhibitor ouabain in human airway epithelial cell line Calu-3.

    Go M, Takano K, Murata M, Koizumi J, Kurose M, Kamekura R, Osanai M, Chiba H, Spray D, Himi T, Sawada N.

    Exp Cell Res   312   3847 - 3856   2006

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  • Evidence for auto/paracrine actions of vitamin D in bone: 1&#61537;-hydroxylase expression and activity in human bone cells.

    van Driel M, Koedam M, Buuman CJ, Hewison M, Chiba H, Uitterlinden AG, Pols HAP, van Leeuwen JPTM.

    FASEB J   20   2417 - 2419   2006

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  • Evidence that both 1&#61537;,25-dihydroxyvitamin D3 and 24-hydroxylated D3 enhance human osteoblast differentiation and mineralization.

    van Driel M, Koedam M, Buurman CJ, Roelse M, Weyts F, Chiba H, Uitterlinden AG, Pols HA, van Leeuwen JP.

    J Cell Biochem   99   922 - 935   2006

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  • Stretch-induced modulation of matrix metalloproteinases in mineralizing osteoblasts via extracellular signal-regulated kinase-1/2.

    Jansen JH, Jahr H, Verhaar JAN, Pols HAP, Chiba H, Weinans H, van Leeuwen JPTM.

    J Orthop Res   24   1480 - 1488   2006

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  • Ghrelin and unacylated-ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a.

    Delhanty PJ, van der Eerden BC, van der Velde M, Gauna C, Pols HA, Jahr H, Chiba H, van der Lely AJ, van Leeuwen JP.

    J Endocrinol   188 ( 1 )   37 - 47   2006

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  • Phosphorylation of ezrin enhances microvillus length via a p38 MAP-kinase pathway in an immortalized mouse hepatic cell line.

    Lan MD, Kojima T, Murata M, Osanai M, Takano K, Chiba H, Sawada N.

    Exp Cell Res   312   110 - 120   2006

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  • Hyperstimulation and a gonadotropin-releasing hormone agonist modulate ovarian vascular permeability by altering expression of the tight junction protein claudin-5.

    Kitajima Y, Endo T, Nagasawa K, Manase K, Honnma H, Baba T, Hayashi T, Chiba H, Sawada N, Saito T.

    Endocrinology   147   694 - 699   2006

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  • Differential expression and subcellular localization of claudin-7, -8, -12, -13 and -15 along the mouse intestine.

    Fujita H, Chiba H, Yokozaki H, Sakai N, Sugimoto K, Wada T, Kojima T, Yamashita T, Sawada N.

    J Histochem Cytochem   54   933 - 944   2006

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  • Reduced expression of claudin-7 correlates with invasion and metastasis in squamous cell carcinoma of the esophagus.

    Usami Y, Chiba H, Nakayama F, Ueda J, Matsuda Y, Sawada N, Komori T, Ito A, Yokozaki H.

    Hum Pathol   37   569 - 577   2006

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  • Glyceraldehyde-derived advanced glycation end-products preferentially induce VEGF expression and reduce GDNF expression in human astrocytes.

    Miyajima H, Osanai M, Chiba H, Nishikiori N, Kojima T, Ohtsuka K, Sawada N.

    Biochem Biophys Res Commun   330 ( 2 )   361 - 366   2005.5

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  • Activation of p21CIP1/WAF1 gene expression and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4α

    Chiba H, Itoh T, Satohisa S, Sakai N, Osanai M, Kojima T, Sawada N.

    Exp Cell Res   302   11 - 21   2005

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  • 11β-Hydroxysteroid dehydrogenase expression and glucocorticoid synthesis are directed by a molecular switch during osteoblast differentiation.

    Eijken M, Hewison M, Cooper MS, Jong de FH, Chiba H, Stewart PM, Uitterlinden AG, Pols HAP, van Leeuwen JPTM.

    Mol Endocrinol   19 ( 3 )   621 - 631   2005

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  • Down-regulation of survival signaling through MAPK and Akt in occludin-deficient mouse hepatocytes in vitro.

    Murata M, Kojima T, Yamamoto T, Go M, Takano K, Osanai M, Chiba H, Sawada N.

    Exp Cell Res   310   140 - 151   2005

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  • p38 MAP-kinase regulates function of gap and tight junctions during regeneration of rat hepatocytes

    Yamamoto T, Kojima T, Murata M, Takano K, Go M, Hatakeyama N, Chiba H, Sawada N

    J Hepatol   42   707 - 718   2005

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  • Tight junction protein MAGI-1 is up-regulated by transfection with connexin32 in an immortalized mouse hepatic cell line: cDNA microarray analysis.

    Murata M, Kojima T, Yamamoto T, Go M, Takano K, Chiba H, Tokino T, Sawada N.

    Cell Tissue Res   319   341 - 347   2005

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  • Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4&#61537;-induced epithelial polarization.

    Satohisa S, Chiba H, Osanai M, Ohno S, Kojima T, Saito T, Sawada N.

    Exp Cell Res   310   66 - 78   2005

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  • 腹部転移巣において未分化転化を認めた甲状腺乳頭癌の1部検例

    村井政史, 水越常徳, 石田禎夫, 鶴間哲弘, 千葉英樹, 丸山怜緒, 高橋文彦, 伊藤嘉行, 安達正晃, 今井浩三.

    癌の臨床   50   405 - 409   2004

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  • 血液組織関門の形成と制御の分子機構

    千葉英樹, 藤田裕樹, 長澤邦彦, 澤田典均

    福岡医誌   95   139 - 145   2004

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  • IL-1βregulates expression of Cx32, occludin, and claudin-2 of rat hepatocytes via distinct signal transduction pathways.

    Yamamoto T, Kojima T, Murata M, Takano K, Go M, Chiba H, Sawada N.

    Exp Cell Res   299   427 - 441   2004

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  • Stretch-induced phosphorylation of ERK1/2 depends on differentiation stage of osteoblasts.

    Jansen JHW, Weyts FAA, Westbroek I, Jahr H, Chiba H, Pols HAP, Verhaar JAN, Leeuwen van JPTM, Weinans H.

    J Cell Biochem   93   542 - 551   2004

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  • Inhibition of MAP-kinase activity moderates changes in expression and function of Cx32 but not claudin-1 during DNA synthesis in primary cultures of rat hepatocytes.

    Kojima T, Yamamoto T, Lan M, Murata M, Takano K, Go M, Ichimiya S, Chiba H, Sawada N.

    Med Mol Morphol   37   101 - 113   2004

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  • Oncogenic raf-1 regulates epithelial to mesenchymal transition via distinct signal transduction pathways in an immortalized mouse hepatic cell line.

    Lan MD, Kojima T, Osanai M, Chiba H, Sawada N.

    Carcinogenesis   25   2385 - 2395   2004

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  • Thr207 of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP.

    Soma T, Chiba H, Kato-Mori Y, Wada T, Yamashita T, Kojima T, Sawada N.

    Exp Cell Res   300   202 - 212   2004

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  • Thr203 of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctions.

    Fujibe M, Chiba H, Kojima T, Soma T, Wada T, Yamashita T, Sawada N.

    Exp Cell Res   295   36 - 47   2004

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  • Hepatocyte nuclear factor (HNF)-4αtriggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells.

    Chiba H, Gotoh T, Kojima T, Satohisa S, Kikuchi K, Osanai M, Sawada N.

    Exp Cell Res   286   288 - 297   2003

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  • “すきま”の細胞生物学―細胞間接着装置タイト結合とヒト疾患―

    澤田典均, 小島隆, 飛岡弘敏, 小海康夫, 千葉英樹

    札幌医学雑誌   72   1 - 7   2003

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  • Tight junctions and human diseases.

    Sawada N, Murata M, Kikuchi K, Osanai M, Tobioka H, Kojima T, Chiba H.

    Med Mol Morphol   36   147 - 156   2003

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  • Regulation of the blood-biliary barrier: interaction between gap and tight junctions in hepatocytes.

    Kojima T, Yamamoto T, Murata M, Chiba H, Kokai Y, Sawada N.

    Med Mol Morphol   36   157 - 164   2003

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  • Role of the p38 MAP-kinase signaling pathway for Cx32 and claudin-1 in the rat liver.

    Kojima T, Yamamoto T, Murata M, Lan M, Takano K, Go M, Ichimiya S, Chiba H, Sawada N.

    Cell Commun Adhes   10   1 - 7   2003

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  • Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways.

    Ishizaki T, Chiba H, Kojima T, Fujibe M, Soma T, Miyajima H, Nagasawa K, Wada I, Sawada N.

    Exp Cell Res.   290   275 - 288   2003

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  • A highly potent 26,27-hexafluoro-1&#61537;, 25-dihydroxyvitamin D3 on calcification in SV40-transformed human fetal osteoblastic cells.

    Miyahara T, Simoura T, Osahune N, Uchida Y, Sakuma T, Nemoto N, Kozakai A, Takamura T, Yamazaki R, Higuchi S, Chiba H, Iba K, Sawada N.

    Calcified Tissue Int   70   488 - 495   2002

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  • Cx32 formation and/or Cx32-mediated intercellular communication induce expression and function of tight junctions in hepatocytic cell line.

    Kojima T, Spray DC, Kokai Y, Chiba H, Mochizuki Y, Sawada N.

    Exp Cell Res.   276   40 - 51   2002

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  • Hepatocyte nuclear factor (HNF)-4αinduces expression of endothelial Fas ligand (FasL) to prevent cancer cell transmigration: A novel defense mechanism of endothelium against cancer metastasis.

    Osanai M, Chiba H, Kojima T, Fujibe M, Kimura H, Satoh M, Sawada N.

    Cancer Sci.   93   532 - 541   2002

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  • Bile canalicular barrier function and expression of tight junctional molecules in rat hepatocytes during common bile duct ligation.

    Takakuwa Y, Kokai Y, Sasaki K, Chiba H, Tobioka H, Mori M, Sawada N.

    Cell Tissue Res   307   181 - 189   2002

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  • Barrier function of microvessels and roles of glial cell line-derived neurotrophic factor in the rat testis.

    Kamimura Y, Chiba H, Utsumi H, Gotoh T, Tobioka H, Sawada N.

    Med Mol Morphol   35   139 - 145   2002

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  • ギャップ結合と細胞分化:ギャップ結合蛋白(Cx32)によるタイト結合の誘導およびアクチン構築の変化

    小島隆,澤田典均,千葉英樹,小海康夫,望月洋一,森道夫

    肝サイトスケルトン研究会誌   11   17 - 22   2001

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  • Phase-independent inhibition by retinoic acid of mineralization correlated with loss of tetranectin expression in a human osteoblastic cell line.

    Iba K, Chiba H, Yamashita T, Ishii S, Sawada N.

    Cell Struct Funct   26   227 - 233   2001

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  • Occludin and claudin-1 concentrate in the midbody of immortalized mouse hepatocytes during cell division.

    Kojima T, Kokai Y, Chiba H, Osanai M, Kuwahara K, Mori M, Mochizuki Y, Sawada N.

    J Histochem Cytochem   49   333 - 339   2001

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  • Cx32 but not Cx26 is associated with tight junctions in primary cultures of rat hepatocytes.

    Kojima T, Kokai Y, Chiba H, Yamamoto M, Mochizuki Y, Sawada N.

    Exp Cell Res,   263   193 - 201   2001

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  • Retinoid X receptorαand retinoic receptor &#61543; mediate expression of genes encoding tight-junction proteins and barrier function in F9 cells during visceral endodermal differentiation.

    Kubota H, Chiba H, Takakuwa Y, Osanai M, Tobioka H, Kohama G, Mori M, Sawada N.

    Exp Cell Res   263   163 - 172   2001

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  • RXRαablation in skin keratinocytes results in alopecia and epidermal alterations.

    Li M, Chiba H, Warot X, Messaddeq N, Gerard C, Chambon P, Metzger D.

    Development   128   675 - 688   2001

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  • F9 embryonal carcinoma cells engineered for tamoxifen-dependent Cre-mediated site-directed mutagenesis and doxycycline-inducible gene expression.

    Chiba H, Chambon P, Metzger D.

    Exp Cell Res   260   334 - 339   2000

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  • Expression of GFR&#61537;-1, receptor for GDNF, in rat brain capillary during postnatal development of the BBB.

    Utsumi H, Chiba H, Kamimura Y, Osanai M, Igarashi Y, Tobioka H, Mori M, Sawada N.

    Am J Physiol-Cell Ph   279   C361-C368   2000

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  • Expression of receptors for glial cell line-derived neurotrophic factor (GDNF) and neurturin in the inner blood-retinal barrier of rats.

    Igarashi Y, Chiba H, Utsumi H, Miyajima M, Ishizaki T, Gotoh T, Kuwahara K, Tobioka H, Satoh M, Mori M, Sawada N.

    Cell Struct Funct   25   237 - 241   2000

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  • Glial cell line&shy;derived neurotrophic factor induces barrier function of endothelial cells forming the blood&shy;brain barrier.

    Igarashi Y, Utsumi H, Chiba H, Yamada&shy;Sasamori Y, Tobioka H, Kamimura Y, Furuuchi K, Kokai Y, Nakagawa T, Mori M, Sawada N.

    Biochem Bioph Res Co,   261   108 112   1999

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  • Inducation of tight junctions in human connexin 32 (hCx32)&shy;transfected mouse hepatocytes: Connexin 32 interacts with occludin.

    Kojima T, Sawada N, Chiba H, Kokai Y, Yamamoto M, Urban M, Lee GH, Hertsberg EL, Mochizuki Y, Spray DC.

    Biochem Bioph Res Co   266   222 229   1999

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  • Mouse p450RAI (CYP26) expression and retinoic acid&shy;inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor &#61543; and retinoid X receptorα

    Abu-Abed SS, Beckett BR, Chiba H, Chithalen JV, Jones G, Metzger D, Chambon P, Petkovich M.

    J Biol Chem   273   2409 - 2415   1998

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  • レチノイドレセプターノックアウト細胞-リガンド依存性Creリコンビナーゼの開発と応用-

    千葉英樹

    医学のあゆみ   186   705 - 710   1998

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  • 骨粗鬆症のリスクファクターである喫煙、特にニコチンアルカロイドのヒト骨芽細胞のアロマターゼチトクロームP450に及ぼす影響.

    宮原龍郎,大島香代,渡辺 誠,澤田典均,射場浩介,千葉英樹,根本信雄.

    Osteoporosis Japan   6 ( 3 )   666 671   1998

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  • Specific and redundant functions of retinoid X receptor/retinoic acid receptor heterodimers in differentation, proliferation, and apoptosis of F9 embryonal carcinoma cells.

    Chiba H, Clifford J, Metzger D, Chambon P.

    J Cell Biol   139   735 - 747   1997

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  • All&shy;trans retinoic acid inhibits dexamethasone&shy;induced ALP activity and mineralization in human osteoblastic cell line SV HFO.

    Nuka N, Sawada N, Iba K, Chiba H, Ishii S, Mori M.

    Cell Struct Funct   22   27 32   1997

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  • Distinct retinoid X receptor&shy;retinoic acid receptor heterodimers are differentially involved in the control expression of retinoid target genes in F9 embryonal carcinoma cells.

    Chiba H, Clifford J, Metzger D, Chambon P.

    Mol Cell Biol   17   3013 - 3020   1997

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  • RXRα-null F9 embryonal carcinoma cells are resistant to the differentiation, anti-proliferative and apoptotic effects of retinoids.

    Clifford J, Chiba H, Sobieszczuk D, Metzger D, Chambon P.

    EMBO J   15   4142 - 4155   1996

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  • Extracellular matrix components induce differentiation of the human osteoblastic cell line SV&shy;HFO in a soluble factor&shy;dependent manner.

    Iba K, Kawaguchi S, Sawada N, Chiba H, Nuka S, Ishii S, Mori M.

    J Bone Miner Metab   14   214 - 221   1996

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  • Phase&shy;dependent effects of transforming growth factorβ1 on osteoblastic markers of human osteoblastic cell line SV&shy;HFO during mineralization.

    Iba K, Sawada N, Nuka S, Chiba H, Obata H, Isomura H, Satoh M, Ishii S, Mori M.

    Bone   19 ( 4 )   363 - 369   1996

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  • Transforming growth factor&shy;β1 downregulates dexamethasone&shy;induced tetranectin gene expression during the in vitro mineralization of the human osteoblastic cell line SV&shy;HFO.

    Iba K, Sawada N, Chiba H, Ulla M Wewer, Ishii S, Mori M.

    FEBS Lett   373 ( 1 )   1 - 4   1995.10

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  • Glucocorticoids induce mineralization coupled with bone protein expression without influence on growth of a human osteoblastic cell line.

    Iba K, Chiba H, Sawada N, Horita S, Ishii S, Mori M.

    Cell Struct Funct   20   319 - 330   1995

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  • Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase.

    Metzger D, Clifford J, Chiba H, Chambon P.

    Proc Natl Acad Sci USA   92   6991 - 6995   1995

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  • Hormonal regulation of connexin 43 expression and gap junctional communication in human osteoblastic cells.

    Chiba H, Sawada N, Oyamada M, Kojima T, Iba K, Ishii S, Mori M.

    Cell Struct Funct   19   173 - 177   1994

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  • Rapid appearance of connexin 26&shy;positive gap junctions in centrilobular hepatocytes without induction of mRNA and protein synthesis in isolated perfused liver of female rat.

    Kojima T, Sawada N, Oyamada M, Chiba H, Isomura H, Mori M.

    J Cell Sci   107   3579 - 3590   1994

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  • Cellular polarity correlates with vimentin distribution, but not to keratin, in human renal cell carcinoma cells in vitro.

    Sasaki M, Sawada N, Chiba H, Miyao N, Tsukamoto T, Satoh M, Mori M.

    Cell Struct Funct   19   115 - 121   1994

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  • 骨粗鬆症に伴う腰背部痛に対する点鼻型サケカルシトニン(SMC20-051)の臨床効果(第1報)-単剤使用とビタミンD3併用使用での比較を中心に-.

    松山敏勝, 宮野須一, 宮嶋俊定, 山村俊昭, 千葉英樹, 益子忠之, 三上尚人, 谷雅彦, 安念俊二, 斉藤断, 斉藤要一, 横沢均, 中島門太, 榊間真二, 楢崎義一, 畑英司, 沢田一二, 石川一郎, 常見健雄, 東館憲州, 早川満.

    診療と新薬   30   765 - 777   1993

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  • Open reduction, bone grafting and external fixation for comminuted intra-articular fractures of the distal radius: early postoperative motion of the wrist using the clyburn dynamic external fixator.

    Aoki M, Ishii S, Usui M, Chiba H, Ooyama N.

    Orthopaedics internal edition   1   198 - 202   1993

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  • A newly established cell line from normal human bone responds to 1α,25&shy;dihydroxyvitamin D3, retinoic acid and transforming growth factorβ1.

    Chiba H, Sawada N, Iba K, Isomura H, Ishii S, Mori M.

    Tumor Res   28   41 - 50   1993

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  • Relationship between the expression of the gap junction protein and osteoblast phenotype in a human osteoblastic cell line.

    Chiba H, Sawada N, Oyamada M, Kojima T, Nomura S, Ishii S, Mori M.

    Cell Struct Funct   18   419 - 426   1993

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  • Establishment and characterization of a simian virus 40&shy;immortalized osteoblastic cell line from normal human bone.

    Chiba H, Sawada N, Ono T, Ishii S, Mori M.

    Cancer Sci   84   290 - 297   1993

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  • ヒト正常骨・軟骨組織およびヒト骨・軟骨肉腫におけるbone gla proteinとosteonectinの局在

    千葉英樹. 松山敏勝

    日整雑誌   67   463 - 472   1993

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  • 肘関節周辺の骨化性筋炎とその処置・対策

    千葉英樹, 薄井正道, 青木光広, 石井清一.

    関節外科   12   198 - 202   1993

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  • われわれの骨粗鬆症専門外来での診断と治療のまとめ

    松山敏勝, 宮嶋俊定, 山村俊昭, 谷雅彦, 千葉英樹, 伊藤正明, 横串算敏, 石井清一, 楢崎義一, 中西浩二, 浅野奨.

    整形外科   44   1831 - 1837   1993

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  • Ileal duplication cyst associated with heterotopic pancreas: Report of a case and literature review.

    Sato T, Oyamada M, Chiba H, Koide S, Yuyama Y, Watabe K, Denno R, Ueda D, Sato N, Mori M, Hirata K.

    Acta Pathologica Japonica   43   597 - 602   1993

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  • 我々の骨粗鬆症専門外来の一年のまとめ

    松山敏勝, 千葉英樹, 宮嶋俊定, 山村俊昭, 大寺浩造, 伊藤正明, 横串算敏, 石井清一, 楢崎義一, 畑栄司.

    北海道整災外   36   41 - 46   1992

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  • 硬組織骨標本での高度測定時における各種影響因子についての検討.

    宮嶋俊定, 松山敏勝, 山村俊昭, 千葉英樹, 石井清一, 中出修, 越智真理, 賀来亨

    硬組織研究技術談話会会誌   1   3 - 4   1992

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  • 女性腰痛患者における各種骨塩定量法による腰椎骨塩量についての研究

    大寺浩造, 松山敏勝, 千葉英樹, 宮嶋俊定, 山村俊昭, 横串算敏, 石井清一.

    北海道整災外   36   33 - 39   1992

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  • 第3腰椎部に発生した巨大砂時計腫の治療経験

    千葉英樹, 本間信吾, 竹林武宏, 長井侃, 山脇慎也, 姥山勇二.

    北海道整災外   35   111 - 116   1991

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  • Dumbell型脊髄腫瘍摘出後の脊柱変形予防について

    横串算敏, 山下敏彦, 横沢均, 千葉英樹.

    東日本臨床整会誌   3   498 - 502   1991

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  • 椎弓を温存した脊髄腫瘍摘出術の経験.

    千葉英樹, 横串算敏, 横沢均, 菅野裕子

    北海道整災外   35   107 - 110   1991

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  • 伏在神経の有痛性神経腫の症例.

    千葉英樹, 石井清一, 薄井正道, 青木光広, 近藤真章.

    東日本臨床整会誌   3   321 - 323   1991

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  • 先天性と思われる鎖骨偽関節例に対する血管柄付遊離腓骨移植術の経験.

    千葉英樹, 石井清一, 薄井正道, 内藤貴文, 山下元吉.

    東日本小児整外会誌   1   11 - 14   1990

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  • 膝蓋骨脱臼・亜脱臼に対するElmslie-Trillat法の経験

    千葉英樹, 寺島嘉昭, 長井侃.

    北海道整災外   34   29 - 34   1990

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  • 上腕骨開放骨折の1例

    千葉英樹, 青柳孝一

    北整・外傷研誌   7   59 - 60   1990

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  • Pilon骨折の2例.

    千葉英樹, 青柳孝一

    北整・外傷研誌   6   12 - 14   1989

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  • 肘関節部外傷性異所性骨化による肘関節拘縮に対する手術療法

    千葉英樹, 石井清一, 薄井正道, 青木光広

    北海道整災外   33   38 - 43   1989

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Books

  • 腎と骨代謝・タイト結合を介したミネラル輸送調節

    (vol.23 No.2)

    日本メディカルセンター  2010.4 

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    Responsible for pages:145-147   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:杉本幸太郎, 藤田裕樹, 稲富周一郎, 澤田典均, 千葉英樹   Publication place:  

  • 実験医学・別冊クローズアップ実験法総集編

    (培養細胞における新しい遺伝子ノックアウト法)

    羊土社  2002 

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    Responsible for pages:49-53   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:千葉英樹   Publication place:  

  • 病気と細胞内小器官―細胞から病気のしくみを理解する

    森道夫(幹細胞と再生医学)

    文光堂  2002 

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    Responsible for pages:206-213   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:千葉英樹   Publication place:  

  • 病気と分子細胞生物学―ゲノムと分子でわかるヒトの病気

    森道夫(新世代の遺伝子ターゲティング)

    メディカル・サイエンス・インターナショナル  2002 

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    Responsible for pages:140-147   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:千葉英樹   Publication place:  

  • 病気と分子細胞生物学―ゲノムと分子でわかるヒトの病気

    森道夫(転写因子の分子生物学と疾患)

    メディカル・サイエンス・インターナショナル  2002 

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    Responsible for pages:172-178   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:千葉英樹   Publication place:  

  • 病気と分子細胞生物学―ゲノムと分子でわかるヒトの病気

    森道夫(核内レセプターの転写制御と疾患)

    メディカル・サイエンス・インターナショナル  2002 

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    Responsible for pages:180-190   Language:Japanese  

    Authors name of the chapter and paper which it took charge of:千葉英樹   Publication place:  

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Presentations

  • 卵巣がんの新規抗体医薬品標的タンパク質の網羅的同定

    第74回日本電気泳動学会総会  

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    Event date: 2023.5

  • 細胞接着分子クローディン 16 は卵巣癌の新規バイオマーカーである

    第74回日本電気泳動学会総会  

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    Event date: 2023.5

  • 二次元電気泳動 / ウエスタンブロット法によるがん患者由来自己抗体の 新規網羅的同定法

    第74回日本電気泳動学会総会  

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    Event date: 2023.5

  • 肝受容体ホモログ -1 の異常セリンリン酸化は膵癌・肝癌の予後不良因 子である

    第112回日本病理学会総会  

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    Event date: 2023.4

  • 卵巣がん患者腹水中に含まれる自己抗体の網羅的同定

    第112回日本病理学会総会  

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    Event date: 2023.4

  • 細胞接着分子クローディンによる卵巣がんの層別化

    第112回日本病理学会総会  

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    Event date: 2023.4

  • CLDN10 は肝細胞癌で異常発現する

    第112回日本病理学会総会  

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    Event date: 2023.4

  • 腎細胞癌における Claudin-10 の分子病理学的解析

    第112回日本病理学会総会  

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    Event date: 2023.4

  • CLDN4-LXR 連関による乳癌の悪性形質制御機構

    第112回日本病理学会総会  

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    Event date: 2023.4

  • 細胞接着-核内受容体シグナルは多彩な細胞機能を制御する

    日本レチノイド研究会第33回学術集会  

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    Event date: 2022.10

  • Spondin-1 は卵巣癌における新規予後マーカーとなり得る

    第111回日本病理学会総会  

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    Event date: 2022.4

  • 卵巣癌に起因する細胞表面タンパク質シグネチャーの同定

    第111回日本病理学会総会  

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    Event date: 2022.4

  • 腎細胞癌における Claudin-10 の臨床病理学的・分子病理学的解析

    第111回日本病理学会総会  

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    Event date: 2022.4

  • 肝受容体ホモログ -1 (LRH1) の異常セリンリン酸化による肝癌と膵癌 の悪性形質増強機構

    第111回日本病理学会総会  

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    Event date: 2022.4

  • Claudin-9 は子宮内膜癌の予後不良因子である

    第111回日本病理学会総会  

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    Event date: 2022.4

  • 卵巣癌新規診断マーカーとしての Claudin-12

    第111回日本病理学会総会  

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    Event date: 2022.4

  • Occludin and tricellulin regulate the complexity of tight junction strand network and epithelial barrier function

    51st NIPS International Symposium "Frontiers in Epithelial Cell Biology"  

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    Event date: 2021.12

  • Occludin and tricellulin jointly form a complex network of tight junction strands to maintain epithelial barrier

    ASCB Cell bio virtual 2021  

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    Event date: 2021.12

  • Surfaceome profiling of ovarian cancer ascites tumor cells for personalized immunotherapy

    日本プロテオーム学会2021年大会  

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    Event date: 2021.7

  • 卵巣がんにおけるSpondin-1タンパク質の発現解析

    第72回日本電気泳動学会総会  

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    Event date: 2021.7

  • Claudin-9は子宮体がんの新規予後マーカーである

    第72回日本電気泳動学会総会  

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    Event date: 2021.7

  • 臨床検体を用いたバイオマーカー研究 細胞接着分子クローディンとがん マーカー分子としての有用性と治療標的としての可能性

    第72回日本電気泳動学会総会  

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    Event date: 2021.7

  • Auto-immunomicsを基盤としたがん患者血清中自己抗体の網羅的探索

    第72回日本電気泳動学会総会  

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    Event date: 2021.7

  • オクルディンとトリセルリンは協調的に細胞間隙の超微細構造を形成し上皮バリアを維持する

    第73回日本細胞生物学会  

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    Event date: 2021.6 - 2021.7

  • Spondin-1の新規卵巣癌診断マーカーとしての有用性

    第110回日本病理学会総会  

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    Event date: 2021.4

  • Claudin-9, a new biomarker for cervical cancer

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    Event date: 2021.4

  • 細胞表面タンパク質解析を基盤とした卵巣癌の新規診断・治療標的の網羅的同定

    第110回日本病理学会総会  

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    Event date: 2021.4

  • 新規抗CLMPモノクローナル抗体の作製と発現部位の解析

    第109回日本病理学会総会  

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    Event date: 2020.7

  • クローディン-6による子宮体癌の悪性形質増強機構

    第109回日本病理学会総会  

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    Event date: 2020.7

  • クローディン-4による乳癌の悪性形質増強機構

    第109回日本病理学会総会  

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    Event date: 2020.7

  • 新規CLDN10, CLDN12抗体の開発とその応用

    第109回日本病理学会総会  

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    Event date: 2020.7

  • CLDN15は悪性胸膜中皮腫の新規診断マーカーである

    第109回日本病理学会総会  

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    Event date: 2020.7

  • ゲノム編集技術を用いたタイト結合分子シンギュリン/パラシンギュリンの 機能解析

    第109回日本病理学会総会  

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    Event date: 2020.7

  • ラットモノクローナル抗体の樹立と有用性

    第5回DSANJ Bio Conference'20 Open  

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    Event date: 2020.1

  • ラットモノクローナル抗体の樹立と有用性-子宮体癌予後予測と悪性中皮腫の新規マーカーを例に-

    新技術説明会  

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    Event date: 2019.11

  • 子宮体癌患者の予後予測バイオマーカー

    ファーマラボEXPO  

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    Event date: 2019.7

  • 幹細胞培養補助剤:JAM-C部分ペプチドは間葉系幹細胞の培養補助剤として有用である

    ファーマラボEXPO  

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    Event date: 2019.7

  • タイト結合分子クローディンに対するモノクローナル抗体の樹立とその応用

    第108回日本病理学会総会  

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    Event date: 2019.5

  • タイト結合分子クローディン-2特異的ラットモノクローナル抗体の有用性

    第108回日本病理学会総会  

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    Event date: 2019.5

  • Liver X receptor(LXR)βは小細胞肺癌治療の新規標的分子になり得る

    第108回日本病理学会総会  

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    Event date: 2019.5

  • JAM-C部分ペプチドを活用した新規幹細胞培養法

    第108回日本病理学会総会  

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    Event date: 2019.5

  • 肺腫瘍塞栓症で死亡した尿路上皮癌の一例

    第108回日本病理学会総会  

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    Event date: 2019.5

  • 細胞接着シグナルによる正常細胞機能とがん悪性形質の新規制御機構

    第107回日本病理学会総会  

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    Event date: 2018.6

  • HCV感染を阻害する新規オクルディン抗体の作用機序解明

    第107回日本病理学会総会  

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    Event date: 2018.6

  • 新規抗ヒトオクルディン単クローン抗体はHCV感染阻害薬になり得るか

    第107回日本病理学会総会  

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    Event date: 2018.6

  • 食道癌再発転移の化学療法中に細菌性心筋炎をきたして死亡した一例

    第107回日本病理学会総会  

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    Event date: 2018.6

  • 可溶性JAM-Cはニッチ基質として間葉系幹細胞の維持に寄与する

    第107回日本病理学会総会  

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    Event date: 2018.6

  • 乳癌におけるC laudin-4高発現の臨床病理学的意義

    第107回日本病理学会総会  

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    Event date: 2018.6

  • ポドサイトにおけるクローディンの異所性発現は細胞間接着分子の再構成を惹起する

    第107回日本病理学会総会  

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    Event date: 2018.6

  • Mutual activation of Claudin-6 and Src family kinases triggers epithelial differentiation via RARγ phosphorylation

    第70回日本細胞生物学会大会  

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    Event date: 2018.6

  • HCV感染を阻害する新規オクルディン抗体は哺乳類で保存されたアミノ酸配列を認識する

    第69回日本細胞生物学会大会  

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    Event date: 2017.6

  • タイト結合分子クローディン-6接着シグナルは子宮内膜癌の悪性形質を増強する

    第69回日本細胞生物学会大会  

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    Event date: 2017.6

  • ヒト脳微小血管モデル培養系におけるクローディン-5制御機構

    第106回日本病理学会総会  

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    Event date: 2017.4

  • 多発心臓転移から心破裂をきたした原発不明扁平上皮癌の一剖検例

    第106回日本病理学会総会  

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    Event date: 2017.4

  • 新規HCV感染阻害抗体はCN配列を認識してオクルディンのエンドサイトーシスを誘導する

    第106回日本病理学会総会  

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    Event date: 2017.4

  • 脂肪由来幹細胞におけるタイト結合分子JAMファミリーの発現と機能解析

    第106回日本病理学会総会  

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    Event date: 2017.4

  • 初期胚幹細胞の上皮分化誘導シグナルにおける核内受容体の役割

    第106回日本病理学会総会  

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    Event date: 2017.4

  • タイト結合分子クローディン-6の発現は子宮内膜癌の予後不良因子である

    第106回日本病理学会総会  

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    Event date: 2017.4

  • オクルディンを標的とした新規HCV感染阻害薬の開発

    第83回日本病理学会東北支部学術集会  

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    Event date: 2016.7

  • ヒト口腔扁平上皮癌の担癌マウスにおけるLXRアゴニストの抗腫瘍効果

    第105回日本病理学会総会  

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    Event date: 2016.5

  • 海馬神経新生のダイナミクスと”老若”ニューロンの分子特性

    第105回日本病理学会総会  

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    Event date: 2016.5

  • ヒト化抗オクルディンモノクローナル抗体はHCV感染を防ぐ

    第105回日本病理学会総会  

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    Event date: 2016.5

  • HCV感染を阻害する新規マウスモノクローナル抗体の開発

    第105回日本病理学会総会  

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    Event date: 2016.5

  • cAMP経路によるポドサイト培養細胞の微絨毛形成機構

    第105回日本病理学会総会  

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    Event date: 2016.5

  • 脂肪組織由来間葉系幹細胞における接着分子JAM ファミリーの発現

    第105回日本病理学会総会  

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    Event date: 2016.5

  • 難治性がんにおけるLiver X 受容体の発現

    第105回日本病理学会総会  

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    Event date: 2016.5

  • 統合失調症前頭前野における血液脳関門構成分子クローディン−5の発現異常とPKAシグナルの活性化

    第105回日本病理学会総会  

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    Event date: 2016.5

  • 幹細胞の上皮分化誘導機構における、核内受容体およびプロテインキナーゼの機能解析

    第105回日本病理学会総会  

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    Event date: 2016.5

  • タイト結合分子クローディン-4の上皮分化誘導能の解析

    第104回日本病理学会大会  

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    Event date: 2015.4

  • クローディン-6の上皮分化誘導シグナルには、SrcとBlkが機能している

    第104回日本病理学会大会  

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    Event date: 2015.4

  • 幹細胞の上皮分化誘導機構において、核内受容体とCldn6シグナルがタイト結合分子の転写活性化に与える影響

    第104回日本病理学会大会  

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    Event date: 2015.4

  • クローディン−6/Srcファミリーキナーゼシグナルは幹細胞の上皮分化を誘導する

    第87回日本生化学会大会  

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    Event date: 2014.10

  • 幹細胞の上皮分化誘導における細胞間接着シグナルと核内受容体の新規クロストーク機構

    第87回日本生化学会大会  

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    Event date: 2014.10

  • 各種プロテインキナーゼ阻害剤を用いた、幹細胞における細胞間接着シグナル-核内受容体クロストーク機構の解明

    第157回日本獣医学会学術集会  

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    Event date: 2014.9

  • Claudin-6-mediated adhesion signal controls stem cell fate via Src-family kinases

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    Event date: 2014.6

  • 細胞間接着シグナルとク核内受容体のクロストークによる幹細胞の新規上皮分化機構

    第66回日本細胞生物学会大会  

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    Event date: 2014.6

  • タイト結合分子クローディン−4の上皮分化誘導能の解析

    第103回日本病理学会大会  

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    Event date: 2014.4

  • S100A14・A16 の発現は乳癌の不良な予後と相関し,乳癌細胞の浸潤を促進する

    第103回日本病理学会総会  

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    Event date: 2014.4

  • クローディン-6とSrc-family kinasesの相互作用は幹細胞の上皮分化を誘導する

    第103回日本病理学会大会  

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    Event date: 2014.4

  • クローディン−6による上皮分化誘導シグナルに関与するsrc family kinase分子の同定

    第103回日本病理学会大会  

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    Event date: 2014.4

  • 幹細胞の運命決定における細胞間接着シグナルと核内受容体の新規クロストーク機構

    第103回日本病理学会総会  

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    Event date: 2014.4

  • LXRアゴニストはコレステロール排出を促進して扁平上皮癌細胞の細胞増殖を抑制する

    第103回日本病理学会大会  

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    Event date: 2014.4

  • タイト結合分子クローディン?4の上皮分化誘導能の解析

    第103回日本病理学会大会  

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    Event date: 2014

  • クローディン?6による上皮分化誘導シグナルに関与するsrc family kinase分子の同定

    第103回日本病理学会大会  

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    Event date: 2014

  • クローディン?6/Srcファミリーキナーゼシグナルは幹細胞の上皮分化を誘導する

    第87回日本生化学会大会  

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    Event date: 2014

  • タイト結合分子クローディン-6はマウス幹細胞株F9とES細胞の上皮分化を誘導する

    第25回高遠シンポジウム  

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    Event date: 2013.8

  • Claudin-6-mediated cell adhesion induces intracellular signaling for epithelial morphogenesis in mouse F9 and embryonic stem cells

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    Event date: 2013.6

  • LXRアゴニストはコレスレロール排出を促進して扁平上皮癌細胞の細胞増殖を抑制する

    第102回日本病理学会総会  

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    Event date: 2013.6

  • クローディン−6による幹細胞の新規上皮分化誘導機構

    第102回日本病理学会総会  

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    Event date: 2013.6

  • クローディン-6による細胞間接着シグナルは幹細胞の上皮分化を誘導する

    第102回日本病理学会総会  

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    Event date: 2013.6

  • クローディン-6の上皮分化誘導シグナルにおけるSrc-family kinasesの関与

    第102回日本病理学会総会  

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    Event date: 2013.6

  • マウス乳癌転移モデルの開発と転移関連遺伝子の探索

    第102回日本病理学会総会  

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    Event date: 2013.6

  • クローディン?6による幹細胞の新規上皮分化誘導機構

    第102回日本病理学会総会  

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    Event date: 2013

  • Tight-junction protein claudin-6 provokes epithelial polarization and cell-cell junction formation in F9 stem cells

    Tight junction symposium 2012  

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    Event date: 2012.11

  • Src family kinase involves in the differentiation of stem cells to epithelial cells

    Tight junction symposium 2012  

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    Event date: 2012.11

  • 肺癌におけるS100A14 発現の臨床病理学的意義と分子機能の解析

    第101回日本病理学会総会  

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    Event date: 2012.4

  • クローディン-6による細胞間接着は幹細胞の上皮分化を誘導する

    第101回日本病理学会総会  

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    Event date: 2012.4

  • クローディン−6によるF9幹細胞の上皮分化へのsrc family kinaseの関与

    第101回 日本病理学会総会  

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    Event date: 2012.4

  • Liver X receptorはヒト口腔扁平上皮癌細胞の細胞増殖に関与している

    第101回日本病理学会総会  

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    Event date: 2012.4

  • 乳腺腫瘍の一例

    第74回日本病理学会東北支部学術集会  

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    Event date: 2012.2

  • クローディンによるF9幹細胞の上皮分化機構

    第57回日本病理学会秋季特別総会  

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    Event date: 2011.11

  • 乳癌におけるS100A14発現の意義

    第57回日本病理学会秋期特別総会  

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    Event date: 2011.11

  • Liver X receptors express in oral cancer tissues and the agonist inhibits cellular growth of oral cancer cell lines

    The 70th Annual Meeting of the Japanese Cancer Association  

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    Event date: 2011.10

  • 乳癌におけるS100A14発現の臨床的意義と分子機能解析

    第100回日本病理学会総会  

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    Event date: 2011.4

  • Laminin alpha1はマウス小脳の発達に重要である

    第100回 日本病理学会総会  

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    Event date: 2011.4

  • タイト結合分子クローディンによる幹細胞の上皮分化誘導機構

    第100回日本病理学会総会  

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    Event date: 2011.4

  • ヒト口腔扁平上皮癌細胞におけるLiver X receptorの発現とそのアゴニストによる増殖抑制効果

    第100回日本病理学会総会  

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    Event date: 2011.4

  • 私の目指したもの、目指すもの―整形外科医が研究者になって―

    中空知整形外科医会  

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    Event date: 2010.11

  • 多彩な生理機能と病気に関わる細胞接着と極性

    第425回福島医学会学術研究集会特別講演  

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    Event date: 2010.10

  • 細胞接着・極性とヒト疾患. シンポジウム「進化する分子形態学的手法を用いた病態診断と治療への応用」

    第42回日本臨床分子形態学会総会  

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    Event date: 2010.9

  • 細胞接着・極性形成とヒト疾患

    第71回日本病理学会東北支部学術集会特別講演  

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    Event date: 2010.7

  • 細胞接着・極性形成の分子機構とその異常

    第46回肝形態科学研究会特別講演  

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    Event date: 2010.5

  • 細胞接着・極性形成の分子機構とその異常.

    第46回肝形態科学研究会特別講演  

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    Event date: 2010.5

  • 細胞間接着と極性形成の制御機構

    第53回日本病理学会秋期特別総会  

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    Event date: 2007.12

  • 細胞接着と極性形成の分子機構

    第40回北海道病理談話会  

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    Event date: 2007.9

  • A novel mechanism underlying vitamin D-dependent Ca2+ absorption between enterocytes.

    In: 4th meeting Bone Biology Forum  

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    Event date: 2007.8

  • 肝疾患の病態とタイト結合.

    第4回 日本病理学会カンファレンス 「肝疾患研究の最前線:現状と課題」  

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    Event date: 2007.7

  • 核内受容体hepatocyte nuclear factor 4alphaは微絨毛と細胞接着の形成を誘導するモルフォルゲンとして働く

    ワークショップ「細胞接着・細胞外基質・細胞間相互作用」第40回日本発生生物学会・第59回日本細胞生物学会大会  

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    Event date: 2007.5

  • The nuclear receptor hepatocyte nuclear factor 4αacts as a morphogen to induce the formation of microvilli

    In: The 46th annual meeting of the American Society for Cell Biology  

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    Event date: 2006.12

  • Differential expression patterns of claudin-7, -8, -12, -13 and -15 in the mouse intestine.

    In: The 46th annual meeting of the American Society for Cell Biology  

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    Event date: 2006.12

  • Tight junctional barrier of human nasal epithelial cells is regulated through a PKC pathway.

    In: International symposiyum on tonsils and mucosal barriers of the upper ways  

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    Event date: 2006.8

  • Molecular mechanism of microvilli formation triggered by HNF-4αand retinoid receptors.

    In: The 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress  

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    Event date: 2006.6

  • Differential expression profiles of claudins 7, 8, 12, 13 and 15 in the mouse intestine.

    In: The 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress  

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    Event date: 2006.6

  • 黄疸と血液胆汁関門. ワークショップ「病態発生とタイト結合とギャップ結合の役割」

    第95回日本病理学会  

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    Event date: 2006.4

  • Glial cell line-derived neurotrophic factor (GDNF) regulates the vascular permeability of the blood-retinal barrier (BRB) .

    In: Experimental Biology  

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    Event date: 2006.4

  • Occludin expression inhibits tumorigenicity and metastasis.

    In: Experimental Biology  

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    Event date: 2006.4

  • Behavior of tight-junction, adherens-junction and cell-polarity proteins during HNF-4α-induced epithelial polarization.

    In: The 45th annual meeting of the American Society for Cell Biology  

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    Event date: 2005.12

  • Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung capillary endothelial cells.

    In: The 45th annual meeting of the American Society for Cell Biology  

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    Event date: 2005.12

  • Activation of p21CIP1/WAF1 gene expression and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4α

    In: The 45th annual meeting of the American Society for Cell Biology  

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    Event date: 2005.12

  • HNF-4αprovokes phosphorylation of CRB3 and develops junctional complexes and epithelial cell polarity.

    In: The 58th JSCB meeting  

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    Event date: 2005.6

  • Involvement of gap junctional intercellular communication in the barrier function of tight junctions of brain and lung capillary endothelial cells.

    In: The 58th JSCB meeting  

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    Event date: 2005.6

  • 核内ステロイド受容体群による癌の分化誘導と増殖抑制の分子基盤. ワークショップ「転写調節因子による腫瘍の表現形質と悪性度の修飾」

    第94回日本病理学会総会  

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    Event date: 2005.4

  • タイト結合の機能調節機構とヒト疾患. シンポジウム「細胞間接着」

    第36回日本臨床電子顕微鏡学会  

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    Event date: 2004.11

  • 核内ステロイド受容体による上皮分化と極性形成の制御機構.(講演)

    その他の会議  

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    Event date: 2004.7

  • 生体バリアの形成と制御の分子機構. ワークショップ「細胞接着分子シグナルと病態」

    第93回日本病理学会総会  

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    Event date: 2004.6

  • Hepatocyte nuclear factor-4αtriggers formation of functional tight junctions and polarized epithelial morphology in F9 embryonal carcinoma cells.

    In: The 57th JSCB meeting  

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    Event date: 2004.5

  • Protein kinase A targets claudin-5 on Thr207 and leads to size-selective loosening of the claudin-5-based endothelial barrier.

    In: The 57th JSCB meeting  

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    Event date: 2004.5

  • 血液組織関門の形成と制御の分子機構

    九大血管病研究カンファレンス  

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    Event date: 2004.3

  • 血液組織関門と上皮分化の制御機構. シンポジウム「組織のホメオスターシスを守る細胞接着装置ギャップ結合とタイト結合の構造, 機能, 病態」

    日本顕微鏡学会第59回学術講演会  

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    Event date: 2003.6

  • 肝細胞のギャップ及びタイト結合. シンポジウム「組織のホメオスターシスを守る細胞接着装置ギャップ結合とタイト結合の構造, 機能, 病態」

    日本顕微鏡学会第59回学術講演会  

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    Event date: 2003.6

  • Hepatocyte nuclear factor (HNF)-4αはタイト結合分子の発現を制御し, 上皮分化と極性形成を誘導する. ワークショップ「細胞の接着とシグナル」

    第56回日本細胞生物学会大会  

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    Event date: 2003.5

  • 血液組織関門の再構成と制御機構. シンポジウム「新たな血管研究の展開」

    第92回日本病理学会総会  

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    Event date: 2003.4

  • Functions of hepatocyte nuclear factor-4&#61537; in epithelial differentiation and proliferation of F9 embryonal carcinoma cells.

    In: The 42th annual meeting of the American Society for Cell Biology  

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    Event date: 2002.12

  • Regulation of Thr203 of Claudin-1 by mitogen-activated protein kinase modulates tight-junction function.

    In: The 42th annual meeting of the American Society for Cell Biology  

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    Event date: 2002.12

  • Cyclic AMP induces expression and threonine-phosphorylation of tight-junction protein claudin-5 in blood-brain barrier endothelial cells.

    In: The 42th annual meeting of the American Society for Cell Biology  

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    Event date: 2002.12

  • 「卵巣過剰刺激症候群ovarian hyperstimulation syndrome(OHSS)における血管透過性のメカニズムについて」 シンポジウム

    第34回日本臨床電子顕微鏡学会  

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    Event date: 2002.9

  • 胆汁うっ滞と血液胆汁関門. シンポジウム「血液組織関門の調節と病態」

    第58回日本電子顕微鏡学会学術講演会  

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    Event date: 2002.9

  • Mammalian cells engineered tamoxifen-dependent Cre-mediated site-directed mutagenesis and doxycycline-inducible gene expression.

    In: 6th World Congress on Advances in Oncology and 4th International Symposium on Molecular Medicine  

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    Event date: 2001.10

  • Inhibition of MAP kinase, PI3-kinase and p38 MAP kinase activities moderates expression and function of gap and tight junctions during DNA synthesis and redifferentiation in primary rat hepatocytes.

    In: 2001 International gap junction conference  

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    Event date: 2001.8

  • Retinoid X receptorαand retinoic acid receptorγmediate expression of genes encoding tight junction proteins and barrier function in F9 cells during visceral endodermal differentiation.

    In: 2000 FASEB summer research conferences  

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    Event date: 2001.6

  • 肝細胞のタイト結合の機能とその調節(培養肝細胞の研究を中心に). シンポジウム「肝細胞の機能ならびに病態解明への超微形態学的アプローチ」

    第57回日本電子顕微鏡学会学術講演会  

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    Event date: 2001.5

  • 核内受容体と生体バリア

    その他の会議  

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    Event date: 2001.4

  • Cx32 formation and/or Cx32 mediated intercellular communication induce tight junctions in hepatocytes.

    In: 40th American Society for Cell Biology Annual Meeting  

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    Event date: 2000.12

  • レチノイドレセプターと細胞分化.

    日本レチノイド研究会第11回学術集会  

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    Event date: 2000.11

  • F9 embryonal carcinoma cell engineered for tamoxifen-dependent Cre-mediated site-directed mutagenesis and doxycycline-inducible gene expression.

    In: European Retinoid Research Group Retinoids '99  

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    Event date: 1999.9

  • Induction of tight junctions in human connexin32-transfected mouse hepatocytes: Interaction of connexin32 with occludin.

    In: 1999 International gap junction conference  

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    Event date: 1999.8

  • A combined system of tamoxifen-activated site-specific recombination and tetracycline-inducible gene expression in mammalian cells.

    In: FASEB Summer Research Conferences  

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    Event date: 1999.8

  • 培養細胞における新しい遺伝子操作法-発癌メカニズムの解明に向けて-

    その他の会議  

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    Event date: 1999.5

  • 新しい遺伝子操作法を用いた生体分子の機能解析

    その他の会議  

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    Event date: 1999.5

  • 培養細胞における部位特異的遺伝子組換え-遺伝子発現誘導複合システムの開発-

    その他の会議  

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    Event date: 1998.8

  • Specific and redundant functions of RXR/RAR heterodimers in differentiation, proliferation, apoptosis and the control of expression of retinoid target genes in F9 embryonal carcinoma cells.

    In: 3rd congress of the Aian-Pacific Organization for Cell Biology  

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    Event date: 1998.8

  • レチノイド受容体の生理機能-リガンド依存性Creリコンビナーゼの開発と応用

    その他の会議  

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    Event date: 1998.5

  • Conditional site-specific recombination with a ligand-inducible Cre recombinase.

    In: Keystone Symposia on Molecular and Cellular Biology  

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    Event date: 1996.3

  • A newly established human cell line (SV-HFO) expresses bone related proteins and mineralizes in vitro.

    In: 2nd Combined Meeting of the Orthopaedic Research Societies of USA, Japan, Canada and Europe  

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    Event date: 1995.11

  • Inhibitory effect of transforming growth factor &#61538;1 on mineralization coupled with differentiated marker regulation in human osteoblastic cell line (SV-HFO): relating to the stage of cell differentiation.

    In: 17th Am Soc Bone & Min Res  

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    Event date: 1995.10

  • Function of extracellular matrix (ECM) and expression of integrin in the differentiation-inducible human osteoblastic cell line, SV-HFO.

    In: 17th Am Soc Bone & Min Res  

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    Event date: 1995.10

  • A newly established human osteoblastic cell line mineralizes in vitro.

    In: 16th Am Soc Bone & Min Res  

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    Event date: 1994.9

  • QCT scan detects earlier stage at bone mineral loss in the menopasusal woman of lumbal vertebrae.

    In: Methodologics for Bone Mineral Assessment  

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    Event date: 1990.11

  • Assesment of bone mineral density using the combination of QCT and DEXA for measurement of menopausal women.

    In: International Conference on Osteoporosis  

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    Event date: 1990.11

▼display all

Industrial property rights

  • 悪性中皮腫鑑別方法, 及び悪性中皮腫鑑別用抗CLDN15抗体

     More details

    Property type:Patent

    Application no:特願2019-162576  Date applied:2019.9

  • 細胞培養補助剤

     More details

    Property type:Patent

    Application no:PCT/JP2019/18862  Date applied:2019.5

  • 子宮体癌患者の予後予測マーカー

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    Property type:Patent

    Application no:PCT/JP2019/12503  Date applied:2019.3

  • C型肝炎ウイルス感染阻害剤

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    Property type:Patent

    Application no:PCT/JP2016/79955  Date applied:2016.10

Awards

  • 第53回日本病理学会秋期特別総会学術研究賞

    2007  

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    Country:Japan

Research Projects

  • 幹細胞ニッチシグナルを利用した組織再生戦略

    2020.4 - 2023.3

    千葉英樹、杉本幸太郎

  • がん悪性形質を左右するエストロゲン受容体新規リン酸化部位に着目した予後予測バイオマーカーの開発

    2020.4 - 2021.3

    千葉英樹、杉本幸太郎, 小林信

  • 細胞接着シグナルを活用した皮膚組織再生技術の開発

    2020.4 - 2021.3

    千葉英樹、杉本幸太郎, 小山明彦, 北村成紀

  • タイト結合分子による腸上皮幹細胞の新規運命決定機構

    2018.4 - 2020.3

    田中瑞子、千葉英樹, 東智仁

  • がん悪性形質を増強する細胞接着シグナルに着目したバイオマーカーの確立

    2018.4 - 2019.3

    千葉英樹、杉本幸太郎, 小島学, 村上祐子

  • 過剰な細胞間接着シグナルによるがんの悪性形質増強機構

    2017.4 - 2020.3

    千葉英樹、杉本幸太郎, 齋藤明

  • 新規ポドサイト傷害マーカーの開発

    2017.4 - 2018.3

    千葉英樹、冨川直樹, 杉本幸太郎, 風間順一郎

  • 細胞接着シグナルを利用した新規ダイレクト・リプログラミング法の開発

    2014.4 - 2016.3

    千葉英樹、井村徹也, 冨川直樹, 柏木維人, 田中瑞子

  • 宿主細胞間接着分子を標的としたC型肝炎の新規予防・治療法の開発

    2014.4 - 2016.3

    冨川直樹、岡井研, 大平弘正, 千葉英樹

  • 原発性ネフローゼ症候群の新規診断マーカーの確立

    2014.4 - 2015.3

    田中瑞子、冨川直樹, 柏木維人, 井村徹也, 千葉英樹

  • 細胞接着シグナルによる新規ダイレクト・リプログラミング法の創出

    2013.7 - 2015.3

  • タイト結合膜貫通分子オクルディンを標的としたC型肝炎の新規治療法の開発

    2011.6 - 2012.3

    千葉英樹、冨川直樹

  • Novel mechanism of epithelial differentiation of stem cells

    2011.3 - 2013.4

  • F9コンディショナルシステムを用いた細胞接着と極性形成の分子基盤解明.

    2010.10 - 2012.9

  • タイト結合の機能細胞病理学-すきまの細胞生物学から治療への応用をめざして(課題番号19390103)

    2008.6 - 2010.3

    澤田典均、小島隆, 千葉英樹, 田中敏, 村田雅樹

  • タイト結合の機能細胞病理学-すきまの細胞生物学から治療への応用をめざして(課題番号19390103).

    2007 - 2009

    澤田典均、小島隆, 千葉英樹, 田中敏, 村田雅樹.

  • 生体バリアとヒト疾患-細胞間隙における分子通過機構の機能分子病理学(課題番号17390117)

    2007 - 2008.3

    小島隆、千葉英樹, 飛岡弘敏, 村田雅樹

  • 細胞間接着と極性形成の制御機構

    2007 - 2008.3

  • 細胞間隙におけるカルシウムイオンチャネルの同定

    2007 - 2008.3

  • 生体バリアと細胞極性形成の制御機構(課題番号19590398)

    2007 - 2008

    千葉英樹、澤田典均, 稲富周一郎

  • 生体バリアとヒト疾患-細胞間隙における分子通過機構の機能分子病理学(課題番号17390117)

    2006 - 2007.3

    小山内誠、小島隆, 千葉英樹, 飛岡弘敏.

  • 生体バリアとヒト疾患-細胞間隙における分子通過機構の機能分子病理学(課題番号17390117)

    2005 - 2006.3

    澤田典均、小島隆, 千葉英樹, 飛岡弘敏, 小山内誠.

  • ギャップ結合の上皮細胞分化誘導によるがん化抑制機構:タイト結合形成およびシグナル伝達を介して

    2005 - 2006.3

    小島隆、千葉英樹, 村田雅樹, 今村将史, 孫誠一, 澤田典均.

  • 生体バリアとヒト疾患-細胞間隙における分子通過機構の機能分子病理学(課題番号17390117)

    2005 - 2006.3

    澤田典均、小島隆, 千葉英樹, 飛岡弘敏, 小山内誠.

  • ギャップ結合の上皮細胞分化誘導によるがん化抑制機構:タイト結合形成およびシグナル伝達を介して

    2005 - 2006.3

    小島隆、千葉英樹, 村田雅樹, 今村将史, 孫誠一, 澤田典均.

  • ラットモデルを用いたpolycystic ovaryの病態研究-blood follicle barrierとインスリン抵抗性の観点から-(課題番号16591676)

    2004 - 2008

    遠藤俊明、千葉英樹

  • 生体バリアの形成と制御の分子機構(課題番号16590322)

    2004 - 2005

    千葉英樹、澤田典均

  • 血液脳関門の形成と制御の分子機構

    2003 - 2004.3

  • 生体バリアの機能分子病理学-細胞間隙における分子通過の制御機構(課題番号14370080)

    2002 - 2004

    澤田典均、千葉英樹, 飛岡弘敏, 小島隆

  • 喫煙の細胞間接着装置, 特にタイト結合とギャップ結合に及ぼす影響

    2002 - 2004

    澤田典均、小島隆, 千葉英樹, 飛岡弘敏

  • 生体バリアの機能分子病理学-細胞間隙における分子通過の制御機構(課題番号14370080)

    2002 - 2004

    澤田典均、千葉英樹, 飛岡弘敏, 小島隆

  • コンディショナルシステムを用いたHepatocyte nuclear factor (HNF)-4αの機能解析

    2002 - 2003.3

  • タイト結合の分子病理学―黄疸, 浮腫, 癌転移の制御のために

    2002 - 2003.3

    澤田典均、千葉英樹, 飛岡弘敏, 小島隆.

  • 遺伝子改変ラット肺血管内皮細胞株を用いた生体バリアの再構築と制御機構の解析(課題番号14570196)

    2002 - 2003

    千葉英樹、澤田典均

  • 正常黄体新生か卵巣過剰刺激症候群発症かを決定付ける因子についての研究(課題番号11671637)

    2002 - 2003

    遠藤俊明、千葉英樹

  • 遺伝子改変マウスF9細胞株を用いた核内受容体の機能解析

    2001 - 2002.3

  • 糖尿病網膜症の基本的研究

    2000 - 2002

    澤田典均、千葉英樹

  • 糖尿病網膜症の基本的研究

    2000 - 2002

    澤田典均、千葉英樹

  • RXRα-RARγの上皮分化における機能平成

    2000 - 2001.3

  • 遺伝子改変F9細胞株を用いた生体バリアの機能解析(課題番号12770114)

    2000 - 2001

    千葉英樹、澤田典均

  • 糖尿病網膜症と血液網膜関門のタイト結合(課題番号12877280)

    2000 - 2001

    澤田典均、千葉英樹

  • 糖尿病網膜症と血液網膜関門のタイト結合(課題番号12877280)

    2000 - 2001

    澤田典均、千葉英樹

  • ヨーロッパなどがん研究先進国との研究交流

    1999 - 2000.3

  • ヒト胎児由来骨芽細胞を素材とした血管周皮細胞への分化誘導と分化関連遺伝子の同定(課題番号11670181)

    1999 - 2000

    池田健、千葉英樹, 澤田典均

  • 細胞株における部位特異的遺伝子組換え・遺伝子発現誘導複合システムの開発

    1998 - 1999.3

  • 脳血管関門のタイト結合調節機構

    1998 - 1999.3

    澤田典均、小海康夫, 飛岡弘敏, 千葉英樹

  • 血管内皮細胞のタイト結合と癌転移

    1998 - 1999.3

    澤田典均、千葉英樹, 飛岡弘敏, 小海康夫.

  • 生体バリアー関連分子の同定と機能解析に関する研究(課題番号10770102)

    1998 - 1999

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Preferred joint research theme

  • 核内受容体新規リン酸化部位に着目したがんの予後予測マーカー開発と創薬

     Cooperative Research with other research organizations including universities.   Cooperative Research with other research organizations including universities. kyodo 

    「がんの悪性形質を左右する核内受容体の新規リン酸化部位」に着目し、予後予測マーカーや分子標的薬の開発に繋げる。

  • 幹細胞ニッチシグナルを利用した組織再生新戦略

     Cooperative Research with Industry-University research organizations and private agencies.   Cooperative Research with Industry-University research organizations and private agencies. kyodo 

    申請者が発見した幹細胞ニッチシグナルに着目し、新たな組織再生法を開発する。