Updated on 2023/12/11

写真a

 
OGURA Masato
 
Organization
Research Facility Attached to the School of Medicine Department of Biomolecular Science Assistant Professor
Title
Assistant Professor

Degree

  • 博士(薬学) ( 2009.3   金沢大学 )

Research Interests

  • Tyrosine Kinase, Mitochondria

Research Areas

  • Life Science / Pharmacology  / General Pharmacology

  • Life Science / Medical biochemistry  / Biochemistry

  • Life Science / Neuroscience-general  / Neuroscience

Education

  • Kanazawa University

    - 2009.3

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    Country: Japan

  • Kanazawa University

    - 2006.3

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    Country: Japan

  • Kanazawa University   Faculty of Pharmaceutical Science

    - 2004.3

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    Country: Japan

Research History

  • 福島県立医科大学医学部附属生体情報伝達研究所生体物質研究部門・講師   講師

    2018.4 - Now

  • 福島県立医科大学医学部附属生体情報伝達研究所生体物質研究部門・助教   助教

    2009.4 - 2018.3

  • 独立行政法人日本学術振興会特別研究員(DC2)

    2007.4 - 2009.3

  • 独立行政法人日本学術振興会二国間交流事業[英国]共同研究による派遣:英国ブリストル大学Peter J. Roberts研究室にて共同研究

    2006.9 - 2007.2

Professional Memberships

  • 分子生物学会

    2023.10 - Now

  • 日本薬理学会

  • その他

  • Current Molecular Pharmacology

  • 福島医学会

  • 日本薬学会

  • 日本神経精神薬理学会

  • 日本神経化学会

  • The Institute of Prophylactic Pharmacology

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Committee Memberships

  • Current Molecular Pharmacology   Editorial Board Member of the journal entitled Current Molecular Pharmacology  

    2020.8 - Now   

  • 予防薬理学研究所   評議員  

    2018.11 - Now   

  • その他   福島県立医科大学・研究連携セミナーワーキンググループ  

    2014.4 - Now   

  • 日本薬理学会   学術評議員  

    2012.4 - Now   

Qualification acquired

  • 薬剤師免許

      200405

Papers

  • Prenylated quinolinecarboxylic acid compound-18 prevents sensory nerve fiber outgrowth through inhibition of the interleukin-31 pathway

    Ogura M, Endo K, Suzuki T, Homma Y.

    PLoS ONE   16 ( 2 )   e0246630   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1371/journal.pone.0246630

  • Astrocyte-Derived Exosomal microRNA miR-200a-3p Prevents MPP+-Induced Apoptotic Cell Death Through Down-Regulation of MKK4

    Shakespear N, Ogura M, Yamaki J, Homma Y

    Neurochemical Research   2020.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1007/s11064-020-02977-5

  • Prenylated quinolinecarboxylic acid derivative prevents neuronal cell death through inhibition of MKK4.

    Ogura M, Kikuchi H, Shakespear N, Suzuki T, Yamaki J, Homma MK, Oshima Y, Homma Y.

    Biochemical Pharmacology   2019.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1016/j.bcp.2018.10.008

  • Mitochondrial reactive oxygen species suppress humoral immune response through reduction of CD19 expression in B cells in mice

    Ogura M, Inoue T, Yamaki J, Homma MK, Kurosaki T, Homma Y

    European Journal of Immunology   47 ( 2 )   406 - 418   2017.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1002/eji.201646342

    PubMed

  • Prenylated quinolinecarboxylic acid derivative suppresses immune response through inhibition of PAK2.

    Ogura M, Kikuchi H, Suzuki T, Yamaki J, Homma MK, Oshima Y, Homma Y.

    Biochemical Pharmacology   105   55 - 65   2016.4

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1016/j.bcp.2016.01.020

    PubMed

  • Upregulation of Slc38a1 Gene Along with Promotion of Neurosphere Growth and Subsequent Neuronal Specification in Undifferentiated Neural Progenitor Cells Exposed to Theanine.

    Takarada T, Ogura M, Nakamichi N, Kakuda T, Nakazato R, Kokubo H, Ikeno S, Nakamura S, Kutsukake T, Hinoi E, Yoneda Y.

    Neurochemical Research   41 ( 1-2 )   5 - 15   2016.2

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1007/s11064-015-1591-4

  • Weight loss by ppc-1, a novel small molecule mitochondrial uncoupler derived from slime mold.

    Suzuki T, Kikuchi H, Ogura M, Homma MK, Oshima Y, Homma Y.

    PLoS ONE   10 ( 2 )   e0117088   2015.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI : 10.1371/journal.pone.0117088

  • Synthesis of prenylated quinolinecarboxylic acid derivatives and their anti-obesity activities.

    Kikuchi H, Suzuki T, Ogura M, Homma MK, Homma Y, Oshima Y.

    Bioorganic & Medicinal Chemistry   23 ( 1 )   66 - 72   2015.1

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1016/j.bmc.2014.11.024

  • Phosphorylation of flotillin-1 by mitochondrial c-Src is required to prevent the production of reactive oxygen species

    Ogura M, Yamaki J, Homma MK, Homma Y.

    FEBS Letters   588 ( 17 )   2837 - 2843   2014.8

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1016/j.febslet.2014.06.044

  • Myosin VI reduces proliferation, but not differentiation, in pluripotent P19 cells.

    Takarada T, Kou M, Nakamichi N, Ogura M, Ito Y, Fukumori R, Kokubo H, Acosta GB, Hinoi E, Yoneda Y

    PLoS ONE   8 ( 5 )   e63947   2013.5

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1371/journal.pone.0063947

  • Promotion of both proliferation and differentiation in pluripotent P19 cells with stable overexpression of the glutamine transporter Slc38a1

    Ogura M, Kakuda T, Takarada T, Nakamichi N, Fukumori R, Kim Y, Hinoi E, Yoneda Y

    PLoS ONE   7 ( 10 )   e48270   2012.10

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1371/journal.pone.0048270

  • Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components.

    Ogura M, Yamaki J, Homma MK, Homma Y.

    Biochemical Journal   447 ( 2 )   281 - 289   2012.10

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1042/BJ20120509

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  • Possible neuroprotective property of nicotinic acetylcholine receptors in association with predominant upregulation of glial cell line-derived neurotrophic factor in astrocytes.

    Takarada T, Nakamichi N, Kawagoe H, Ogura M, Fukumori R, Nakazato R, Fujikawa K, Kou M, Yoneda Y.

    Journal of Neuroscience Research   90 ( 11 )   2074 - 2085   2012.11

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    Language:English   Publishing type:Research paper (other academic)  

    DOI : 10.1002/jnr.23101

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  • Exacerbated vulnerability to oxidative stress in astrocytic C6 glioma cells with stable overexpression of the glutamine transporter slc38a1.

    Ogura M, Takarada T, Nakamichi N, Kawagoe H, Sako A, Nakazato R, Yoneda Y.

    Neurochemistry International   58 ( 4 )   504 - 511   2011.1

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    Language:English   Publishing type:Research paper (other academic)  

  • A protein-protein interaction of stress-responsive myosin VI endowed to inhibit neural progenitor self-replication with RNA binding protein, TLS, in murine hippocampus.

    Takarada T, Tamaki K, Takumi T, Ogura M, Ito Y, Nakamichi N, Yoneda Y.

    Journal of Neurochemistry   110 ( 5 )   1457 - 1468   2009.6

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    Language:English   Publishing type:Research paper (other academic)  

  • Theanine, an ingredient of green tea, inhibits [3H]glutamine transport in neurons and astroglia in rat brain.

    Kakuda T, Hinoi E, Abe A, Nozawa A, Ogura M, Yoneda Y.

    Journal of Neuroscience Research   86 ( 8 )   1846 - 1856   2008.6

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    Language:English   Publishing type:Research paper (other academic)  

  • Activator protein-1 responsive to the group II metabotropic glutamate receptor subtype in association with intracellular calcium in cultured rat cortical neurons.

    Sugiyama C, Nakamichi N, Ogura M, Honda E, Maeda S, Taniura H, Yoneda Y.

    Neurochemistry International   51 ( 8 )   467 - 475   2007.5

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    Language:English   Publishing type:Research paper (other academic)  

  • Upregulation of the glutamine transporter through transactivation mediated by cAMP/protein kinase A signals toward exacerbation of vulnerability to oxidative stress in rat neocortical astrocytes.

    Ogura M, Taniura H, Nakamichi N, Yoneda Y.

    Journal of Cellular Physiology   212 ( 2 )   375 - 385   2007.8

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    Language:English   Publishing type:Research paper (other academic)  

  • Functional expression of a glutamine transporter responsive to downregulation by lipopolysaccharide through reduced promoter activity in cultured rat neocortical astrocytes.

    Ogura M, Nakamichi N, Takano K, Oikawa H, Kambe Y, Ohno Y, Taniura H, Yoneda Y.

    Journal of Neuroscience Research   83 ( 8 )   1447 - 1460   2006.6

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    Language:English   Publishing type:Research paper (other academic)  

  • Stimulation of ubiquitin-proteasome pathway through the expression of amidohydrolase for N-terminal asparagine (Ntan1) in cultured rat hippocampal neurons exposed to static magnetism.

    Hirai T, Taniura H, Goto Y, Ogura M, Sng J, Yoneda Y.

    Journal of Neurochemistry   96 ( 6 )   1519 - 1530   2006.3

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    Language:English   Publishing type:Research paper (other academic)  

  • Oxidative metabolites are involved in polyamine-induced microglial cell death.

    Takano K, Ogura M, Yoneda Y, Nakamura Y.

    Neuroscience   134 ( 4 )   1123 - 1131   2005.7

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    Language:English   Publishing type:Research paper (other academic)  

  • Counteraction by repetitive daily exposure to static magnetism against sustained blockade of N-methyl-D-aspartate receptor channels in cultured rat hippocampal neurons.

    Hirai T, Taniura H, Goto Y, Tamaki K, Oikawa H, Kambe Y, Ogura M, Ohno Y, Takarada T, Yoneda Y.

    Journal of Neuroscience Research   80 ( 4 )   491 - 500   2005.5

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    Language:English   Publishing type:Research paper (other academic)  

  • Protection by exogenous pyruvate through a mechanism related to monocarboxylate transporters against cell death induced by hydrogen peroxide in cultured rat cortical neurons.

    Nakamichi N, Kambe Y, Oikawa H, Ogura M, Takano K, Tamaki K, Inoue M, Hinoi E, Yoneda Y.

    Journal of Neurochemistry   93 ( 1 )   84 - 93   2005.4

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    Language:English   Publishing type:Research paper (other academic)  

  • An increase in intracellular free calcium ions by nicotinic acetylcholine receptors in a single cultured rat cortical astrocyte.

    Oikawa H, Nakamichi N, Kambe Y, Ogura M, Yoneda Y.

    Journal of Neuroscience Research   79 ( 4 )   535 - 544   2005.2

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    Language:English   Publishing type:Research paper (other academic)  

  • Neuronal and glial responses to polyamines in the ischemic brain.

    Takano K, Ogura M, Nakamura Y, Yoneda Y.

    Current Neurovascular Research   2 ( 3 )   213 - 223   2005.7

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    Language:English   Publishing type:Research paper (other academic)  

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Books

  • Advances in Biochemistry in Health and Disease

    (Role for Protein Kinase CK2 on Cell Proliferation: Assessing CK2 Complex Components in the Nucleus During the Cell Cycle Progression)

    Springer  2015  ( ISBN:978-3-319-14543-3

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    Responsible for pages:197-226   Language:English  

    Authors name of the chapter and paper which it took charge of:Miwako Kato Homma, Takeshi Shibata, Toshiyuki Suzuki, Masato Ogura, Hiroko Kozuka-Hata, Masaaki Oyama, and Yoshimi Homma   Publication place:  

Presentations

  • Mechanism of neurotoxic astroglial activation by mitochondrial reactive oxygen species

    2023.12  

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    Event date: 2023.12

  • Glial-derived secreted protein Tinagl1 regulates neuronal survival

    第96回日本薬理学会年会  

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    Event date: 2022.11 - 2022.12

  • Elucidation of the mechanism of substantia nigra astroglial cell activation by metabolic reactive oxygen species

    第95回日本薬理学会年会  

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    Event date: 2022.3

  • Prenylated quinolinecarboxylic acid compound-18 prevents sensory nerve fiber outgrowth through inhibition of the interleukin-31 pathway

    第94回日本薬理学会年会  

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    Event date: 2021.3

  • Prenylated quinolinecarboxylic acid derivative prevents neuronal cell death through inhibition of MKK4

    第92回日本薬理学会年会  

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    Event date: 2019.3

  • Prenylated quinolinecarboxylic acid derivative suppresses immune response through inhibition of PAK2

    第90回日本薬理学会年会  

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    Event date: 2017.3

  • Phosphorylation of respiratory chain components by mitochondrial c-Src is required for neuronal viability

    Neuroscience2016  

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    Event date: 2016.11

  • ミトコンドリア内c-Srcによる活性酸素種産生制御機構の解明

    第65回日本薬理学会北部会  

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    Event date: 2014.9

  • Phosphorylation of respiratory complex I and II by c-Src is required for neuronal viability

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    Event date: 2013.3

  • 活性酸素種産生を制御する新規コハク酸脱水素酵素相互作用タンパク質の同定と機能解析

    第85回日本生化学会大会  

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    Event date: 2012.12

  • Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components

    The 11th Biennial Meeting of the Asian-Pacific Society for Neurochemistry / 55th Annual Meeting of the Japanese Society for Neurochemistry  

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    Event date: 2012.10

  • 呼吸機能におけるミトコンドリア内c-Srcの役割

    第54回日本神経化学会大会  

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    Event date: 2011.9

  • ミトコンドリアc-Srcキナーゼ活性を制御する新規相互作用タンパク質の同定と機能解析

    第84回日本生化学会大会  

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    Event date: 2011.9

  • ミトコンドリアc-Srcによる細胞死制御メカニズム

    日本生化学会東北支部第77回例会・シンポジウム  

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    Event date: 2011.7

  • Regulatory mechanism of oxidative phosphorylation by mitochondrial c-Src

    Keystone Symposia  

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    Event date: 2011.1

  • Regulation of oxidative phosphorylation by mitochondrial c-Src

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    Event date: 2010.12

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Industrial property rights

  • プレニルオキシキノリンカルボン酸誘導体

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    Property type:Patent

    Application no:PCT/JP2013/077937  Date applied:2013.10

  • 体重増加制御剤

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    Property type:Patent

    Application no:2012-230985  Date applied:2012.10

Awards

  • 日本薬理学会年会優秀発表賞

    2013.3  

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    Country:Japan

Research Projects

  • 反応性アストロサイト制御分子PAK2キナーゼの機能解析

    2021.4 - 2024.3

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    科学研究費補助金/学術研究助成基金助成金(基盤研究(C))

  • プレニルオキシキノリンカルボン酸誘導体によるアストロサイト活性化制御機構の解明と創薬応用

    2019.3 - 2020.3

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    若手研究者共創型Prism/大日本住友製薬

  • 代謝性活性酸素種による黒質アストログリア細胞活性化機構の解明とその制御物質の同定

    2018.4 - 2021.3

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    科学研究費補助金/学術研究助成基金助成金(基盤研究(C))

  • 性差を示す代謝性活性酸素種によるドパミン神経変性機構の解明と治療物質の探索

    2017.5 - 2018.3

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    育成研究(福島県立医科大学研究支援事業)

  • ミトコンドリア活性酸素種に起因する神経変性モデルの構築と新規疾患分子の同定

    2015.4 - 2017.3

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    科学研究費補助金/学術研究助成基金助成金(若手研究(B))

  • 活性酸素に起因する体液性免疫不全マウスの分子機序解析と新規疾患分子の同定

    2014.5 - 2015.3

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    育成研究(福島県立医科大学研究支援事業)

  • ミトコンドリア機能を標的とする粘菌由来新規天然物の作用機序解析と創薬応用

    2013.8 - 2014.3

    小椋 正人、本間 好

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    研究成果最適展開支援プログラム(A-STEP)探索タイプ(科学技術振興機構)

  • 活性酸素を起因とする神経変性モデルマウスの構築と新規疾患分子の同定

    2013.5 - 2014.3

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    育成研究(福島県立医科大学研究支援事業)

  • ミトコンドリア内c-Src活性制御に関わる新規相互作用タンパク質の同定と機能解析

    2011.4 - 2013.3

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    科学研究費補助金/学術研究助成基金助成金(若手研究(B))

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Social Activities

  • 福島テックプラングランプリ2019

    2019.7

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  • Medical Creation Fukushima 2014

    2014.10

  • 日本生化学会 東北支部 第76回 例会・シンポジウム 庶務

    2010.5

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Media Coverage

  • 創薬 新技術説明会 発表

    2016.12