日本語

Institute of Biomedical Sciences  Department of Biomolecular Science

Associate Professor HOMMA   Miwako K. Tel.024-547-1660 Fax.024-548-3041

■ Career 日本学術振興会特別研究員  1987/04/01-1989/03/31  東京医科歯科大学医学部　文部教官・助手  1989/04/01-1997/01/31  福島県立医科大学医学部　助手  1997/02/01-Present  福島県立医科大学医学部　講師  2005/10/01-Present    ■ Academic degrees 医学博士  The University of Tokyo    医学修士  The University of Tokyo      ■ Current state of research and teaching activities Protein kinase CK2 is a highly conserved serine/threonine kinase that functions in multiple cellular processes including cell growth and development. It is typically found in tetrameric complexes consisting of two catalytic alpha and/or alpha’ subunits, and two regulatory beta subunits. We reported the cell-cycle dependent association of CK2 with adenomatous polyposis coli (APC) that regulates CK2 activity, and identified its downstream target as eukaryotic translation initiation factor 5 (eIF5). We focus on the regulatory mechanisms and structural dynamics of CK2 in relation to its role for cell proliferation.      ■ Current research field Functional Biochemistry  Structural Biochemistry  Molecular Biology    ■ Research keywords cell cycle, CK2, casein kinase 2, kinase, growth signal transduction, Phospholipase C, Inositol Phospholipid, Intracellular signal transduction system, Familial adenomatous coli, Colon Cancer, APC, CK2, eIF5    ■ Subject of research Functional and stuructural analysis of protein kinase CK2  kinase, phosphorylation, structure, activity, function  2009-2015  　 Regulatory role of protein kinase CK2 during the progression of cell cycle  kinase, CK2, cell cycle  2008-2015  Study on signal transduction system in human colorectal carcinomas.  cancer, growth signal, colorectal carcinoma  2001-    ■ Proposed theme of joint or funded research Phosphoproteomics Analysis by Mass Spectrometry Structural Analysis of Functional Proteins  Joint research with other research organizations such as universities.    Regulatory roles of protein kinases in cell growth  Wish to undertake joint research with industry and other organizations including private sector.  Technical consultation,Joint research  View details...   ■ Books 本間　美和子  細胞周期の制御を中心とする増殖シグナル伝達機構に関する研究      Journal of Society for Japanese Women Scientists      2008  1346-9827  Tadaomi Takenawa, Miwako Kato and Akio Yamakawa    /,317-322    Phosphatidylinositol kinase and cell transformation    Adv. Second Messenger and Phosphoprotein Research  1989    View details...   ■ Papers Joint  Kabuyama Y., Nakazawa N., Yamaki J., Homma M.K., and Homma Y.  Dysregulation of very long chain acyl-CoA dehydrogenase coupled with lipid peroxidation.  Am. J. Physiol. Cell Physiol.  298/ 1, 107-113  2010        Joint  Yukihito Kabuyama, Takuya Kitamura, Junko Yamaki, Miwako K. Homma, Shin-ichi Kikuchi and Yoshimi Homma.  Involvement of thioredoxin reductase 1 in the regulation of redox balance and viability of rheumatoid synovial cells.  Biochem.Biophys.Res.Commun.  367, 491-496  2008        Joint  Miwako K. Homma and Yoshimi Homma.  Cell Cycle and activation of CK2  Mol.Cell.Biochem.  316/ 1-2, 49-55  2008/04        Joint  Takuya Kitamura, Yukihito Kabuyama, Akihisa Kamataki, Miwako K. Homma, Hideo Kobayashi, Shigeo Aota, Shin-ichi Kikuchi and Yoshimi Homma.  Enhancement of lymphocyte migration and cytokine production by ephrinB1 system in rheumatoid arthritis.  Am. J. Physiol. Cell Physiol.  294, C189-C196  2008        Joint  Yukihito Kabuyama, Kengo Oshima, Takuya Kitamura, Miwako K. Homma, Junko Yamaki, Mitsuru Munakata, and Yoshimi Homma.  Involvemnet of selenoprotein P in the regulation of redox balance and myofibroblast viability in idiopathic pulmonary fibrosis.  Genes to Cells  12, 1235-1244  2007        View details...   ■ Research presentations Conference presentation  Involvement of CK2 phosphorylation for its activity and nuclear localiztion during the cell cycle progression of normal human fibroblasts.  Keystone Symposia on “The Evolution of Protein Phosphorylation”  2011/01/23    Conference presentation  Autophosphorylation of CK2 at the N-terminal region is required for its catalytic activity.  Cold Spring Harbor Laboratory Symposium“Protein Data Bank 40th”  2011/10/29    Conference presentation  Regulatory mechanisms involved in the activation of nuclear CK2  The 14th Meeting on Protein Phosphorylation and Cell Signaling  2008/08    Conference presentation  CK2 changes its cellular localization during the progression of cell cycle  Cold Spring Harbor Laboratory Meeting on Cell Cycle  2008/05      Cell cycle-regulated phosphorylation and nuclear translocation of CK2.  5th International Conference on Protein Kinase CK2, Protien Kinase CK2 and Disease  2007/09/15    View details...   ■ Academic awards 福島県立医科大学　職務功績職員表彰  2008/09  Domestic  日本女性科学者の会奨励賞  2008/06/14  Domestic  View details...   ■ Alloted class Biochemistry on Signal Transduction Mechanism  Molecular Biology in Medicine  Biochemistry on Pathological Mechanism  Basic Medical Science  Basic Medical Science and Experiments  View details...   ■ Social activities MEXT network for iPS cell research  2010/07/01-Present  先端技術の広報活動  2008/10-2010/03  科学技術政策の動向調査と提言（ライフサイエンス、医学分野）  2005/09-2007/03  EPIMEWS  2010/03-Present  SJWS  2010-Present  View details...   ■ Memberships of academic societies 日本癌学会 -Present  Domestic 日本生化学会 -Present  Domestic 日本分子生物学会 -Present  Domestic 男女共同参画委員 2007/04-Present   ■ Director and committee career 2007年-　日本分子生物学会　男女共同参画委員 2010年- 文部科学省iPS細胞等研究ネットワークiPS Trend監修者 2010年―　男女共同参画学協会連絡会　理事 2012年―　福島高等学校　評議員