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Radioisotope Center
Radioisotope Center
Introduction
This center involves a legally controlled hot area. All the experiments using radioactivity must be performed in this area. The researchers who carry out such experiments must be legally authorized and registered to this center.
This center was established in 1960 on the Sugitsuma campus and then was renewed in 1988 on the Hikarigaok campus. The area for experimental use is 750m2.
The list of thirty-five nuclides of unsealed sources and one nuclide of a sealed source are registered to the government.
Research
Physicochemical aspects of many kinds of intermediate radical species and the behavior of bio-radicals have been studied by use of electron spin resonance (ESR) as a strong strategy.
(K.Nakagawa) Three projects are going on:
(1) investigation of electron transfer to quinone and phenol compounds in inhomogeneous solution systems,
(2) physical properties of micelle and vesicles using spin probe methodology and ESR spectroscopy, and
(3) monosaccharides radicals generated by heavy ion irradiation.
Education
1. Training of the safe handling of radioactivity and the radiation protection for the researchers who intend to be a registrant of this center.
2. Lectures of an introduction to the nuclear chemistry and the nuclear medicine for the students of the medical school.
3. Lectures of the safe handling of radioactivity and the radiation protection for the students of the medical school.
Publications
1. K. Nakagawa, gDiffusion Coefficient and Relaxation Time of Aliphatic Spin Probes in a Unique Triglyceride Membrane,h Langmuir, in press (2003).
2. K. Nakagawa, gSpin-Lattice Relaxation Times of Aliphatic Spin Probes in a Unique Triglyceride Membrane,h Chem. Lett., 666-667 (2002).
3. K. Nakagawa, gPhotochemical Reactions of Antioxidant Sesamol in Aqueous Solution,h J. Am. Oil Chem. Soc., 77(11), 1205-1208 (2000).
4. K. Nakagawa, gEffect of Chemotherapy on Ascorbate and Ascorbyl Radical in Cerebrospinal Fluid and Serum of Acute Lymphoblastic Leukemia,h Cell. Mol. Biol., 46 (8), 1375-1381 (2000).
5. K. Nakagawa and T. Nishio, gElectron Paramagnetic Resonance Investigation of Sucrose Irradiated with Heavy Ions,h Radiat. Res., 153 (6), 835-839 (2000).
6. MATSUMOTO Seiji, MORI Norio, TSUCHIHASI Nobuaki, OGATA Tateaki, Lin Yijing,@YOKOYAMA Hidekatsu, ISHIDA Shin-ichi, gEnhancement of Nitroxide-Reducing Activity in Rats after Chronic Administration of Vitamine E,Vitamine C and Idebenone Examined by an In Vivo Electron Spin Resonance,h Magn. Reson. Med., 40, 330-333 (1998).
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