血液内科学講座の最近の業績一覧

2017年
【論文】

Masahiko Fukatsu, Takenobu Murakami, Hiroshi Ohkawara, Shunichi Saito, Kazuhiko Ikeda, Suguru Kadowaki, Itaru Sasaki, Mari Segawa, Tomoko Soeda, Akihiko Hoshi, Hiroshi Takahashi, Akiko Shichishima-Nakamura, Kazuei Ogawa, Yoshihiro Sugita, Hitoshi Ohto, Yasuchika Takeishi, Takayuki Ikezoe, Yoshikazu Ugawa. A possible role of low regulatory T cells in anti-acetylcholine receptor antibody positive myasthenia gravis after bone marrow transplantation. BMC Neurology 17 (1), 93, 2017

Miki Furukawa, Hiroshi Ohkawara, Kazuei Ogawa, Kazuhiko Ikeda, Koki Ueda, Akiko Shichishima-Nakamura, Emi Ito, Jun-ichi Imai, Yuka Yanagisawa, Reiko Honma, Shinya Watanabe, Satoshi Waguri, Takayuki Ikezoe, Yasuchika Takeishi.  Autocrine and paracrine interactions between multiple myeloma cells and bone marrow stromal cells by growth arrest-specific gene 6 cross-talk with interleukin-6. Journal of Biological Chemistry 292 (10), 4280-4292, 2017

W Chien, QY Sun, LW Ding, A Mayakonda, S Takao, L Liu, SL Lim, KT Tan, M Garg, A De Sousa Maria Varela, J Xiao, N Jacob, K Behrens, C Stocking, M Lill, V Madan, N Hattori, S Gery, S Ogawa, S Wakita, Takayuki Ikezoe, LY Shin, T Alpermann, T Haferlach, H Yang, HP Koeffler. Diagnosis and relapse: cytogenetically normal acute myelogenous leukemia without FLT3-ITD or MLL-PTD. Leukemia 31 (3), 762-766, 2017

Bin Pan, Xiangmin Wang, Chie Nishioka, Goichi Honda, Akihito Yokoyama, Lingyu Zeng, Kailin Xu, Takayuki Ikezoe. G-protein coupled receptor 15 mediates angiogenesis and cytoprotective function of thrombomodulin. Scientific Reports 7 (1), 692, 2017

Koki Ueda, Kazuhiko Ikeda, Takayuki Ikezoe, Kayo Harada-Shirado, Kazuei Ogawa, Yuko Hashimoto, Takahiro Sano, Hiroshi Ohkawara, Satoshi Kimura, Akiko Shichishima-Nakamura, Yuichi Nakamura, Yayoi Shikama, Tsutomu Mori, Philip J. Mason, Monica Bessler, Soji Morishita, Norio Komatsu, Kotaro Shide, Kazuya Shimoda, Shuhei Koide, Kazumasa Aoyama, Motohiko Oshima, Atsushi Iwama, Yasuchika Takeishi. Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasms. Blood Advances 1 (15), 1001-1015, 2017

Shinsuke Kojima, Chie Nishioka, SungGi Chi, Akihito Yokoyama, Takayuki Ikezoe. In vitro studies on the role of recombinant human soluble thrombomodulin in the context of retinoic acid mediated APL differentiation syndrome. Leukemia Research 63, 1-9, 2017

Chie Nishioka, Takayuki Ikezoe, Bin Pan, Kaikin Xu, Akihito Yokoyama. MicroRNA-9 plays a role in interleukin-10-mediated expression of E-cadherin in acute myelogenous leukemia cells. Cancer Science 108 (4), 685-695, 2017

Ling-Wen Ding, Takayuki Ikezoe, Kar-Tong Tan, Masakazu Mori, Anand Mayakonda, Wenwen Chien, De-Chen Lin, Yan-Yi Jiang, Michael Lill, Henry Yang, Qiao-Yang Sun, H. Phillip Koeffler              . Mutational profiling of a MonoMAC syndrome family with GATA2 deficiency. Leukemia 31 (1), 244-245, 2017

Dai Maruyama, Kensei Tobinai, Michinori Ogura, Toshiki Uchida, Kiyohiko Hatake, Masafumi Taniaki, Kiyoshi Ando, Kunihiro Tsukasaki, Takashi Isida, Naoki Kobayashi, Kenichi Ishizawa, Yoichi Tatsumi, Koji Kato, Toru Kiguchi, Takayuki Ikezoe, Eric Laille, Tokihiro Ro, Hiromi Tamakoshi, Sanae Sakurai, Tomoko Ohtsu. Romidepsin in Japanese patients with relapsed or refractory peripheral T-cell lymphoma: a phase / and pharmacokinetics study. International Journal of Hematology 106 (5), 655-665, 2017

Hiroshi Ohkawara, Miki Furukawa, Kazuhiko Ikeda, Akiko Shichishima-Nakamura, Masahiko Fukatsu, Takahiro Sano, Koki Ueda, Satoshi Kimura, Risa Kanai, Yuka Oka, Fumi Murakami, Osamu Suzuki, Yuko Hashimoto, Kazuei Ogawa, Takayuki Ikezoe      . Steroid-resistant autoimmune myelofibrosis in a patient with autoimmune hepatitis and Evans syndrome complicated with increased expression of TGF-β in the bone marrow: a case report. International Journal of Hematology 106 (5), 718-724, 2017

Kazuhiko Ikeda, Koki Ueda, Takahiro Sano, Kazuei Ogawa, Takayuki Ikezoe, Yuko Hashimoto, Soji Morishita, Norio Komatsu, Hitoshi Ohto, Yasuchika Takeishi. The amelioration of myelofibrosis with thrombocytopenia by a JAK1/2 inhibitor, ruxolitinib, in a post-polycythemia vera myelofibrosis patient with a JAK2 exon 12 mutation . Internal Medicine 56, 1705-1710, 2017

Masumi Sukegawa, Xiangmin Wang, Chie Nishioka, Bin Pan, Kailin Xu, Hiroshi Ohkawara, Yoichi Hamasaki, Masayuki Mita, Kenichi Nakamura, Masatoshi Okamoto, Hiromi Shimura, Masatsugu Ohta, Takayuki Ikezoe. The BCR/ABL tyrosine kinase inhibitor, nilotinib, stimulates expression of IL-1β in vascular endothelium in association with downregulation of miR-3p. Leukemia Research 58, 83-90, 2017

Bin Pan, Xiangmin Wang, Shinsuke Kojima, Chie Nishioka, Akihito Yokoyama, Goichi Honda, Kailin Xu, Takayuki Ikezoe. The fifth epidermal growth factor like region of thrombomodulin alleviates LPS-induced sepsis through interacting with GPR15. Thrombosis and Haemostasis 117 (3), 570-579, 2017

Bin Pan, Xiangmin Wang, Shinsuke Kojima, Akihito Yokoyama, Goichi Honda, Kaikin Xu, Takayuki Ikezoe. The fifth epidermal growth factor-like region of thrombomodulin alleviates murine graft-versus-host disease in a G-protein coupled receptor 15 dependent manner. Biology of Blood and Marrow Transplantation 23 (5), 746-756, 2017

Takayuki Ikezoe, J Yang, C Nishioka, B Pan, K Xu, M Furihata, K Nakamura, H Yurimoto, Y Sakai, G Honda, A Yokoyama. The fifth epidermal growth factor-like region of thrombomodulin exerts cytoprotective function and prevents SOS in a murine model. Bone Marrow Transplantation 52 (1), 73-79, 2017

Takayuki Ikezoe, J Yang, C Nishioka, K Umezawa, A Yokoyama. Thrombomodulin blocks calcineurin inhibitor-induced vascular permeability via inhibition of Src/VE-cadherin axis. Bone Marrow Transplantation 52 (2), 245-251, 2017


【学会発表】
〈国際学会〉

国際血栓止血学会 2017 (2017.7.8-7.13, ベルリン) Bin Pan, Xiangmin Wang, Chie Nishioka, Goichi Honda, Akihito Yokoyama, Lingyu Zeng, Kailin Xu, Takayuki Ikezoe. G-protein coupled receptor 15 mediates angiogenesis and cytoprotective function of thrombomodulin

59回 米国血液学会年次総会 (2017.12.9-12.12, オーランド)Yasutaka Ueda, Naoshi Obara, Yuji Yonemura, Hideyoshi Noji, Takahisa Matsuda, Hirozumi Akiyama, Takayuki Ikezoe, Shigeru Chiba, Yoshinobu Kanda, Tatsuya Kawaguchi, Tsutomu Shichishima, Hideki Nakakuma, Shinichiro Okamoto, Jun-Ichi Nishimura, Yuzuru Kanakura and Haruhiko Ninomiya. Effects of Eculizumab Treatment on the Quality of Life in Patients with Paroxysmal Nocturnal Hemoglobinuria Treated in Japan

59回 米国血液学会年次総会(2017.12.9-12.12, オーランド)Takahiro Sano, Koki Ueda, Kazuhiko Ikeda, Kazuei Ogawa, Tsutomu Mori and Takayuki Ikezoe . Functional Impairment of Hematopoietic Stem/Progenitor Cells By Loss of Uhrf2 in Mice

59回 米国血液学会年次総会(2017.12.9-12.12, オーランド)Xiangmin Wang, Bin Pan, Goichi Honda, Yuko Hashimoto, Hiroshi Ohkawara, Kailin Xu, Lingyu Zeng, Takayuki Ikezoe. The C Loop of Fifth Epidermal Growth Factor-like Domain of Thrombomodulin Exerts Cytoprotective and Angiogenic Effects in Vitro and In Vivo

〈国内総会〉
◯シンポジウム・パネルディスカッション

39回 日本血栓止血学会学術集会 (2017.6.9, 名古屋) 池添隆之. 新しい敗血症診療ガイドラインとDIC診療の進歩 4:急性前骨髄球性白血病に合併するDICの治療法の提案(日本救急医学会ジョイントシンポジウム)             

15回 日本臨床腫瘍学会学術集会(2017.7.27-7.29, 神戸 ) Hayato Kamata. Discussant: Takayuki Ikezoe. Impact of clinical pharmacists collaborating with oncologists in outpatient cancer chemotherapy on cost of chemotherapy

11回 日本血栓止血学会学術標準化委員会シンポジウム (2017.1.21, 東京) 池 成基, 池添隆之. DIC診断基準(旧厚生省)には満たさないものの抗凝固療法が必要であった凝固異常合併症悪性リンパ腫症例の臨床的特徴

◯一般演題
15回 日本臨床腫瘍学会学術集会(2017.7.27-7.29, 神戸) Masahiko Fukatsu. Successful treatment of refractory, non-transplant eligible chronic myeloid leukemia in blast crisis with ponatinib

79回 日本血液学会学術集会 (2017.10.20-10.22, 東京) Sho Takeyasu, Hiroshi Ohkawara, Koichiro Fukuchi, Xiangmin Wang, Koki Ueda, Kazuhiko Ikeda, Kazuei Ogawa, Takayuki Ikezoe. A critical role of growth arrest-specific gene 6 in the pathogenesis of HSCT-associated TMA

79回 日本血液学会学術集会 (2017.10.20-10.22, 東京) Masumi Sukegawa, Xiangmin Wang, Chie Nishioka, Bin Pan, Kailin Xu, Hiroshi Ohkawara, Yoichi Hamasaki, Masayuki Mita, Ken-Ichi Nakamura, Masatoshi Okamoto, Masatsugu Ohta, Takayuki Ikezoe. Nilotinib stimulates expression of IL-1β in association with downregulation of miR-3121-3p

79回 日本血液学会学術集会 (2017.10.20-10.22, 東京) Takahiro Sano, Koki ueda, Kazuhiko Ikeda, kazuei Ogawa, Tsutomu Mori, Takayuki Ikezoe. Loss of UHRF2 may alter HSCs function via disruption of histone H3K9 modification

79回 日本血液学会学術集会 (2017.10.20-10.22, 東京) 原田佳代, 野地秀義, 深津真彦, 佐野隆浩, 植田航希,七島晶子, 木村 哲, 大河原浩, 池田 和彦, 小川一英, 池添隆之. 単施設における骨髄異形成症候群に関する後方視的検討

〈地方会〉
123回 日本血液学会東北地方会 (2017.2.19, 仙台) 深津真彦, 助川真純, 七島晶子, 大河原浩, 佐野隆浩, 植田航希, 木村 哲, 池田和彦, 野地 秀義, 小川一英, 池添隆之. 腹水貯留を伴う慢性骨髄単球性白血病にアザシチジン・エトポシド併用が奏功した1
2016年

1.       Ikezoe T. Diagnosis and management of DIC complicated by hematological malignancies. Rinsho Ketsueki. 2016;57(10):2136-2144.

2.       Mori Y, Ikeda K, Inomata T, Yoshimoto G, Fujii N, Ago H, Teshima T. Ruxolitinib treatment for GvHD in patients with myelofibrosis. Bone Marrow Transplant. 2016 Dec;51(12):1584-1587.

3.       Takahashi N, Kameoka J, Takahashi N, Tamai Y, Murai K, Honma R, Noji H, Yokoyama H, Tomiya Y, Kato Y, Ishizawa K, Ito S, Ishida Y, Sawada K, Harigae H. Causes of macrocytic anemia among 628 patients: mean corpuscular volumes of 114 and 130 fL as critical markers for categorization. Int J Hematol. 2016 Sep;104(3):344-57.

4.       Tajima K, Takahashi N, Ishizawa K, Murai K, Akagi T, Noji H, Sasaki O, Wano M, Itoh J, Kato Y, Scichishima T, Ishida Y, Harigae H, Sawada K; Tohoku Hematology Forum. High prevalence of diffuse large B-cell lymphoma in occult hepatitis B virus-infected patients in the Tohoku district in Eastern Japan. J Med Virol. 2016 Dec;88(12):2206-2210.

5.       Mori M, Ikezoe T, Arakawa Y, Yokoyama A. Digital necrosis associated with chronic cold haemagglutinin disease. Br J Haematol. 2016 Aug;174(3):343.

6.       Abe Y, Miura T, Yoshida MA, Ujiie R, Kurosu Y, Kato N, Katafuchi A, Tsuyama N, Kawamura F, Ohba T, Inamasu T, Shishido F, Noji H, Ogawa K, Yokouchi H, Kanazawa K, Ishida T, Muto S, Ohsugi J, Suzuki H, Ishikawa T, Kamiya K, Sakai A. Analysis of chromosome translocation frequency after a single CT scan in adults. J Radiat Res. 2016 Jun;57(3):220-6.

7.       Ueda K, Ikeda K, Ogawa K, Sukegawa M, Sano T, Kimura S, Suzuki O, Hashimoto Y, Takeishi Y. Favorable outcome of Epstein-Barr virus-associated B-cell lymphoproliferative disorder complicated by immunoglobulin G4-related disease treated with rituximab-based therapy: a case report. J Med Case Rep. 2016 Aug 24;10(1):236.

8.       Nishioka C, Ikezoe T, Yang J, Yokoyama A. BCR/ABL increases EZH2 levels which regulates XIAP expression via miRNA-219 in chronic myeloid leukemia cells. Leuk Res. 2016 Jun;45:24-32.

9.       Madan V, Shyamsunder P, Han L, Mayakonda A, Nagata Y, Sundaresan J, Kanojia D, Yoshida K, Ganesan S, Hattori N, Fulton N, Tan KT, Alpermann T, Kuo MC, Rostami S, Matthews J, Sanada M, Liu LZ, Shiraishi Y, Miyano S, Chendamarai E, Hou HA, Malnassy G, Ma T, Garg M, Ding LW, Sun QY, Chien W, Ikezoe T, Lill M, Biondi A, Larson RA, Powell BL, Lübbert M, Chng WJ, Tien HF, Heuser M, Ganser A, Koren-Michowitz M, Kornblau SM, Kantarjian HM, Nowak D, Hofmann WK, Yang H, Stock W, Ghavamzadeh A, Alimoghaddam K, Haferlach T, Ogawa S, Shih LY, Mathews V, Koeffler HP. Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia. Leukemia. 2016 Aug;30(8):1672-81.

10.    Shikama Y, Cao M, Ono T, Feng X, Noji H, Kimura H, Ogawa K, Suzuki Y, Ikeda K, Takeishi Y, Kimura J. Reduction of c-Fos via Overexpression of miR-34a Results in Enhancement of TNF- Production by LPS in Neutrophils from Myelodysplastic Syndrome Patients. PLoS One. 2016 Aug 11;11(8):e0158527.

11.    Sun H, Lin DC, Guo X, Kharabi Masouleh B, Gery S, Cao Q, Alkan S, Ikezoe T, Akiba C, Paquette R, Chien W, Müller-Tidow C, Jing Y, Agelopoulos K, Müschen M, Koeffler HP. Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia. Oncotarget. 2016 Apr 5;7(14):18736-49.

12.    Nomura S, Maeda Y, Ishii K, Katayama Y, Yagi H, Fujishima N, Ota S, Moriyama M, Ikezoe T, Miyazaki Y, Hayashi K, Fujita S, Satake A, Ito T, Kyo T, Tanimoto M. Relationship between HMGB1 and PAI-1 after allogeneic hematopoietic stem cell transplantation. J Blood Med. 2016 Jan 18;7:1-4.

13.    Hiroshi Ohkawara, Akiko Shichishima-Nakamura, Kazuhiko Ikeda, Masumi Sukegawa, Miki Furukawa, Takahiro Sano, Koki Ueda, Satoshi Kimura, Akiomi Yoshihisa, Hideyoshi Noji, Kazuei Ogawa, Yasuchika Takeishi. Infected pancreatic pseudocyst ruptured into stomach and colon associated with splenic artery pseudoaneurysm. JOP. Journal of the Pancreas 17, 324-327, 2016.